Tests for the absorption of 75Se-labelled homocholic acid conjugated with taurine (75Se-HCAT)

Schroth, H.-J.; Berberich, R.; Feifel, G.; Müller, Kirsten; Ecker, K. W.

doi:10.1007/bf00256590

Cited by 3 publications

(2 citation statements)

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“…However, as in previous reports (Schroth et al 1985), severe bile acid malabsorption and greatly decreased VSSe-HCAT retention times were associated with ileal resection. In summary, measuring ileal function with the 7SSe-HCAT test and 14C-glycochol breath test is a reliable procedure for documenting late radiation damage of the small intestine.…”

Section: Discussionsupporting

confidence: 78%

Imaging and retention measurements of selenium 75 homocholic acid conjugated with taurine, and the carbon 14 glycochol breath test to document ileal dysfunction due to late radiation damage

et al. 1991

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In order to assess ileal dysfunction in patients with complaints after pelvic radiation therapy, retention measurements and scintigraphic imaging with selenium 75 homocholic acid conjugated with taurine (VSSe-HCAT), combined with the carbon 14 glycochol breath test, were evaluated in 39 patients. In 22 patients without ileal resection the results of the 75Se-HCAT test and the breath test differentiated between a normal functioning ileum (both tests negative) and ileal dysfunction as a cause of complaints (one or both tests positive). Among the patients with ileal dysfunction, the combination of both tests permitted those with bacterial overgrowth (breath test positive, 7SSe-HCAT negative) to be separated from patients with evidence of bile acid malabsorption (75Se-HCAT positive, breath test positive or negative). In 17 patients with small-bowel resection, the VSSe-HCAT test helped to estimate the severity of bile acid malabsorption with implications for therapy. In this group the breath test was false-negative in 7 cases with abnormal VSSe-HCAT. Additional systematically performed scintigraphic imaging improved the accuracy of the 7SSe-HCAT test, revealing cases with prolonged colonic accumulation of the radiopharmaceutical, causing spurious retention values. In conclusion, assessment of ileal dysfunction by nuclear medicine techniques in post-irradiation conditions provides information about the aetiology and therefore the possibility of adjustment in the clinical management.

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Section: Discussionsupporting

confidence: 78%

Imaging and retention measurements of selenium 75 homocholic acid conjugated with taurine, and the carbon 14 glycochol breath test to document ileal dysfunction due to late radiation damage

et al. 1991

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“…Data from Schroth et al [13] suggest that for this group a value of less than 2% is considered abnormal. Several authors have found that all patients in this group have retention values of less than 10% [1,[6][7][8]12].…”

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confidence: 97%

Bile acid malabsorption and SeHCAT

Arasaradnam

Cullis

Nwokolo

et al. 2012

Nuclear Medicine Communications

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Experience with a gastrointestinal marker (51CrCl3) in a combined study of ileal function using 75SeHCAT and 58CoB12 measured by whole body counting.

Smith

Bjarnason

1990

Gut

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Introduction of a radioactive gastrointestinal marker (5"CrC13) into a combined study ('5SeHCAT+58CoBl2) of ileal function by whole body counting has been undertaken. The technique was assessed in 23 subjects (15 patients with inflammatory bowel disease, six on non-steroidal anti-inflammatory drugs for rheumatoid arthritis, and two normal subjects). Mean (SD) 51CrC13 retention was only 4-1 (6.0)% on day 4, and was similar on day 7 in subjects given a second dose of "CrCl3 on day 4. Only one subject had more than 20% of 51CrC13 retention after four days. A 5"CrC13 correction method adequately corrected for colonic hold up of 5'CoB12, when compared with final equilibrium values of wCoBl2 retention. Use of the non-absorbed 58CoB12 fraction as a gastrointestinal marker gave good agreement with the 51CrCl3 method in correcting 75SeHCAT values. In all subjects studied, corrections for colonic retention of 71SeHCAT on day 4, were small (<7% of dose) and did not affect the assessment of any subject. In conclusion, an additional gastrointestinal marker such as 51CrCl3 is unnecessary in our combined study since that role can be effected, when indicated, by the non-absorbed 58CoB12 fraction.marker, 5"CrCI3,'5 to monitor and correct for colonic retention of 75SeHCAT measured by abdominal counting using a gamma camera.Vitamin B12 is also absorbed predominantly at the terminal ileum, but by a different mechanism to that for SeHCAT, and the combined use of radiolabelled B12 and SeHCAT has been successfully exploited by whole body counting.'6'0 In our combined study of 75SeHCAT and "8CoB12,6 it was suggested that analysis of the relative patterns of retention of the two test substances could be used to check for evidence of colonic retention. It was considered prudent, however, to attempt to apply the I'CrC13 gastrointestinal marker technique in our whole body counting protocol to substantiate this claim and furthermore to assess and quantify the influence of colonic retention on the overall results. We therefore incorporated "CrCl3, administered orally and together with 75SeHCAT and '8CoB12 (plus intrinsic factor), in our combined test of ileal function'6 to assess the efficiency of colonic emptying on three study days (days 4, 7, and 10), and to consider the prospects for correcting the "SeHCAT and '8CoB12, retention values in patients with inflammatory bowel disease and non-steroidal anti-inflammatory drug enteropathy.

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Tests for the absorption of 75Se-labelled homocholic acid conjugated with taurine (75Se-HCAT)

Cited by 3 publications

References 3 publications

Imaging and retention measurements of selenium 75 homocholic acid conjugated with taurine, and the carbon 14 glycochol breath test to document ileal dysfunction due to late radiation damage

Imaging and retention measurements of selenium 75 homocholic acid conjugated with taurine, and the carbon 14 glycochol breath test to document ileal dysfunction due to late radiation damage

Bile acid malabsorption and SeHCAT

Experience with a gastrointestinal marker (51CrCl3) in a combined study of ileal function using 75SeHCAT and 58CoB12 measured by whole body counting.

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