An upper limit of 15 ng/L instead of 10 ng/L for basal pCT-C is able to detect all MTC and reduce false-positive cases. The prevalence of MTC in nodular thyroid disease in our group was approximately 1.8 per thousand.
The described protocol represents an easily reproduced and reliable method for SN detection in breast cancer. Furthermore, the number of visualized axillary nodes reflects the histologic status of the axilla.
A method for the labeling of leucocytes with 99mTc-colloid is described. The labelling can be done in samples of whole blood, because the colloid is only taken up by the phagocytosing cells, the monocytes and the granulocytes. The part of the colloid that is not phagocytosed is brought to a soluble state with Na-citrate, so that only the phagocytosed colloid is reinjected. The labelling efficiency with this method is between 80% and 90%. Measurements of the activity in the leucocytes 3 h after reinjection, have shown that at least 50% of the labelled cells are at this time still available in the blood pool. The clinical results on 32 patients with the tentative diagnosis of an abdominal abscess and on 42 patients with the tentative diagnosis of septic loosening of an endoprosthesis have shown that the labelled leucocytes are very well suited to show up local foci of inflammation.
Two 99mTc-labelled radio-diagnostics for bone scintigraphy, dicarboxypropan-diphosphonic acid (DPD) and methylene-diphosphonate (MDP) were compared. The test parameters were the time-activity curves of serum and of deproteinised serum, time-activity curves in regions of interest above the femur, the sacrum and the soft tissue medial of the femur, and the urinary excretion. The ratio of bone lesion to normal bone was compared for 6 h after the injection of each compound. The time-activity curves in the serum and the deproteinised serum were not very different, therefore the percentage of the radio-diagnostics bound to protein in blood were nearly the same. At 14 h post-injection nearly 80% of the activity remaining in the blood pool was bound to protein. The urinary excretion of MDP was 25% higher than that of DPD, because the renal clearance of DPD was 41% lower than that of MDP. The non-excreted activity was bound to bone; therefore in the regions of interest set above the sacrum, the femur and the soft tissue the activity ratio was 27% higher for DPD for the ratio os sacrum to soft tissue and 21% higher for the ratio femur to soft tissue, but there were similar results for both substances for the ratio bone lesion to normal bone; therefore MDP was not better than DPD in detecting bone lesions.
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