Testosterone treatment for men with chronic heart failure

Pugh, Peter J.; Jones, Richard D.; West, J. M.; Jones, T. Hugh; Channer, KS

doi:10.1136/hrt.2003.014639

Cited by 204 publications

(166 citation statements)

References 5 publications

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“…The increased risk of arterial and venous thromboembolism associated with HRT and the OCP, may not occur with testosterone replacement therapy in men, since physiological doses of testosterone do not adversely affect blood coagulation factor expression. This negative finding is important, since recent research has shown that testosterone is beneficial in patients with angina (13)(14)(15)(16)(17) and chronic heart failure (40,41). The findings of this study suggest that male hormone replacement therapy may provide cardiovascular benefit without adversely affecting blood coagulation.…”

Section: Discussionmentioning

confidence: 68%

Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina

et al. 2005

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Objective: In women, sex hormones cause increased morbidity and mortality in patients with coronary heart disease (CHD) and adversely affect the coagulation profile. We have studied the effect of physiological testosterone replacement therapy in men on coagulation factor expression, to determine if there is an increased risk of thrombosis. Methods: Double-blind, randomized, placebo-controlled trial of testosterone in 46 men with chronic stable angina. Measurements of free, total and bioavailable testosterone, luteinising hormone (LH) and follicle-stimulating hormone (FSH), estradiol, plasminogen activator inhibitor-1 (PAI-1), fibrinogen, tissue plasminogen activator (tPA) and full blood count were made at 0, 6 and 14 weeks.

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Section: Discussionmentioning

confidence: 68%

Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina

et al. 2005

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“…Testosterone replacement therapy 87 either cardiovascular disease or frailty (Table 3) [53,56,64,[82][83][84][85]. In these studies, the mortality was higher in the placebo treated group.…”

Section: Testosterone and Arrhythmiamentioning

confidence: 66%

Testosterone replacement therapy and cardiovascular risk factors modification

2011

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Hypogonadism in males is associated with increased atherosclerotic disease. Physiologically, testosterone appears to have both positive and negative effects on the cardiovascular system. Testosterone decreases angina and may improve the cardiac healing response after myocardial infarction. Testosterone enhances function in males with heart failure (HF). Testosterone causes water retention and oedema is common in older persons. Oedema should not be used to diagnose HF in older persons. Studies in older persons with HF and frailty have shown a non-statistically lower mortality rate compared to those receiving placebo.

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“…In HF, the treatment through exercise promotes improvement in the musculoskeletal structure and function as well as of hyperventilation induced by exertion (higher ventilatory efficiency), which results in increase of exercise tolerance (18) . In the few investigations carried out, muscle strength and physical performance improvement derived from the TRT were demonstrated (13,23,24) . In one of the studies IM testosterone was applied for three months (13) .…”

Section: Effects Of Testosterone Replacement Of Supplementation (Trt)mentioning

confidence: 99%

“…In the few investigations carried out, muscle strength and physical performance improvement derived from the TRT were demonstrated (13,23,24) . In one of the studies IM testosterone was applied for three months (13) . In another study (23) , the patients were submitted to transdermal testosterone application and were followed for one year.…”

Section: Effects Of Testosterone Replacement Of Supplementation (Trt)mentioning

confidence: 99%

“…Decrease of these hormones is related to age and contributes to gradual worsening of tolerance to exertion in older men (8,9) . Testosterone deficiency and consequent worsening of the anabolism/catabolism ratio is a pathophysiological characteristic of patients, even young ones, with advanced HF (10)(11)(12)(13)(14) , contributing to the decrease of muscle mass, weakness, fatigue, dyspnea and cachexia. However, the TRT effects in patients with HF, even with severe androgenic deficiency and cachexia clinical episode, have been little investigated until the present moment.…”

Section: Testosterone and Exercise Synergism In Heart Failurementioning

confidence: 99%

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Reposição hormonal e exercício físico no tratamento da insuficiência cardíaca: revisão sistemática

Carvalho

Mara

Ulbrich

2011

Rev Bras Med Esporte

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Background: Despite the full use of pharmacological and non-pharmacological therapy, morbidity and mortality incidence as a result from heart failure (HF) are still significantly persistent. In the therapeutic context, the inhibition of inadequate neuro-hormonal and metabolic adaptations, as well the information on the anabolic deficiency that develops in HF becomes relevant. However, just recently some studies about the benefits of the testosterone replacement or supplementation therapy (TRT) have emerged. Objective: to review studies that address the TRT in heart failure (HF), particularly those developed in the ideal setting for clinical treatment, including physical exercise program. Methods: the Scielo and Pubmed databases, Cochrane of Systematic Review and Clinical Control Trials from Cochrane Collaboration databases were analyzed. Results: The few studies about TRT in patients with HF showed improvement in hemodynamic function, insulin resistance, functional capacity and neuro-hormonal and neuromuscular responses, highlighted the controversy regarding the influence on the inflammatory profile, and found no changes in function and structure in the central cardiovascular system. However, studies about TRT associated with exercise programs have not been found. Conclusion: the present state of knowledge, although based on a few studies, allows considering TRT in the treatment of patients with HF. The ideal choice of TRT, regarding for example, treatment duration and inclusion and exclusion criteria is not well-defined yet. There is a wide gap in the literature, calling attention to the lack of studies about TRT concomitant with full medical treatment which includes a physical exercise program.

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Testosterone treatment for men with chronic heart failure

Cited by 204 publications

References 5 publications

Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina

Testosterone does not adversely affect fibrinogen or tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) levels in 46 men with chronic stable angina

Testosterone replacement therapy and cardiovascular risk factors modification

Reposição hormonal e exercício físico no tratamento da insuficiência cardíaca: revisão sistemática

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