Testosterone level in aging male with different glucose tolerance state and its association with osteocalcin

Lu, Yanhui; Li, Jian; Cheng, Xiaoling; Li, Nan; Miao, Xinyu; Sun, Beicheng; Yan, Shuangtong; Li, Chunlin

doi:10.1080/13685538.2018.1481940

Cited by 10 publications

(10 citation statements)

References 25 publications

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“…Arthur et al [40] and Boeri et al [58] reported significantly lower SHBG levels in pre-diabetic patients compared to controls. Similarly, a significant, inverse correlation between SHBG and glucose homeostasis was detected in pre-diabetic men [12] as well as in the subgroup of patients with IFG [61] . However, five studies reported lower SHBG concentrations in euglycemic controls compared to pre-diabetic patients, leaving the association between SHBG serum levels and pre-diabetes unclear [46,56,57,60,62] .…”

Section: Male Hypogonadism Prevalence In Pre-diabetesmentioning

confidence: 71%

“…However, it is not clear whether pre-diabetes results in SHBG reduction [12,40,58,63] or not [40,46,56,62] . Thus, despite the association between reduced total T serum levels and pre-diabetes, there is no clear evidence of a reduction in bioavailable T. Similarly, estradiol serum levels were described to be reduced [46,56,58] or not [40,57,61,62] in prediabetic patients, leaving doubts about the clinical consequences of the reduction of total T serum levels in pre-diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, estradiol serum levels were reported in eight studies, showing a significant direct relationship with IFG [12,40,46,[56][57][58][61][62][63] . In detail, estradiol serum levels were significantly lower in pre-diabetic patients compared to controls in three studies [46,56,58] , whereas five studies did not detect any significant difference [40,57,61,62] .…”

Section: Male Hypogonadism Prevalence In Pre-diabetesmentioning

confidence: 99%

“…Goodman-Gruen et al [61] evaluated 266 prediabetic subjects, highlighting either total T serum levels or bioavailable T serum levels lower in IFG Rabijewski et al [46] , 2016 To investigate the relationships between anabolic hormones and body composition in middle-aged and elderly men with pre-diabetes compared to controls and IGT. This large population-based study confirmed that men with IFG and IGT have reduced total T serum levels, similarly to T2DM, regardless of total body fat, body fat distribution, physical activity, and smoking [61] . This result, although interesting, is partly in contrast with a previous work of Rabijewski et al [46] , which reported lower T in IGT compared to IFG patients.…”

Section: Male Hypogonadism Prevalence In Pre-diabetesmentioning

confidence: 99%

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Male hypogonadism and pre-diabetes interplay: association or causal interaction? A systematic review

Greco¹,

Corleto²,

Ebert³

et al. 2021

MTOD

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Aim:The association between type 2 diabetes mellitus (T2DM) and male hypogonadism has been largely demonstrated. Testosterone (T) serum levels are often lower in men with T2DM compared to the general population, and, conversely, men with higher T serum levels have shown lower risk of T2DM. On the contrary, the association between pre-diabetes and male hypogonadism has been less investigated thus far. Pre-diabetes is a common clinical condition preceding T2DM and has been recognized as a potential risk factor for other metabolic disorders and cardiovascular diseases. Therefore, the aims of this review are to investigate the association between pre-diabetes and male hypogonadism and to evaluate the potential effect of T treatment on glucose metabolism and anti-diabetic therapy on T serum levels. Methods:We conducted this systematic review developing different literature searches, following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis protocol.Results: In our analysis, male hypogonadism has a prevalence of around 24%-35% in pre-diabetic men. Moreover, we observed improvement of metabolic parameters in pre-diabetes with T treatment. On the contrary, antidiabetic therapy seems to have no particular effects on T serum levels. Conclusion:Overall, we demonstrated that, although T administration could be considered in pre-diabetic men, pre-diabetes-related treatments should be confined to the control glucose metabolism, since no evidence for a positive effect on total T serum levels is available. Future research should be oriented to study the role of new antidiabetic drugs in the sex hormonal status in hypogonadal men.

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Section: Male Hypogonadism Prevalence In Pre-diabetesmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Male Hypogonadism Prevalence In Pre-diabetesmentioning

confidence: 99%

Section: Male Hypogonadism Prevalence In Pre-diabetesmentioning

confidence: 99%

See 2 more Smart Citations

Male hypogonadism and pre-diabetes interplay: association or causal interaction? A systematic review

Greco¹,

Corleto²,

Ebert³

et al. 2021

MTOD

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“…Testosterone can be converted into dihydrotestosterone (DHT) to bind to receptors and gets to work . It is an anabolic hormone maintaining muscle quality and bone density …”

Section: Introductionmentioning

confidence: 99%

Association of serum testosterone with different classes of glucose metabolism and the mediation effect of obesity: The Henan Rural Cohort Study

Jiang

Liu

et al. 2019

Diabetes Metabolism Res

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Aims:We aimed to investigate the association of serum testosterone with impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM) and calculate the proportion explained by obesity status on the relationship. Materials and Methods:A case-control study including 2775 participants was performed. Serum testosterone was quantified by liquid chromatography-tandem mass spectrometry. Conditional logistic regression and multivariable linear regression were performed to estimate the relationships between testosterone and different glucose status. Waist circumference (WC) was used as a mediator to estimate the mediation effect.Results: After adjusting for multiple variables, serum testosterone levels were negatively associated with T2DM in males (per 1 unit natural log-transformed, odd ratio (OR) = 0.73, 95% confidence interval (CI): 0.56, 0.96; Tertile 3 vs Tertile 1, OR = 0.46, 95% CI:0.29, 0.72) while were positively in females (per 1 unit natural logtransformed, OR = 1.56, 95% CI:1.32, 1.84; Tertile 3 vs Tertile 1, OR = 3.55, 95% CI: 2.22, 5.66). In males, a higher testosterone tended to be associated with a lower fasting plasma glucose level and a weaker HOMA2-IR but a stronger HOMA2-β.Opposite findings were observed in females. Furthermore, WC played a full and partial mediating role in the relationship between testosterone and IFG and T2DM both in males and females.Conclusion: Serum testosterone levels had opposite effects on IFG and T2DM in males and females. With higher serum testosterone levels, the dysglycemia progression was decreased among males while increased among females. In addition, WC played a full and partial mediating role in the relationship between testosterone and IFG and T2DM.

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The correlation between testosterone and stroke and the mediating role of blood pressure: The Henan rural cohort study

Liu

Wei

Nie

et al. 2022

Journal of Stroke and Cerebrovascular Diseases

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Testosterone level in aging male with different glucose tolerance state and its association with osteocalcin

Abstract: It showed that serum osteocalcin and TT were closely related with BMI, blood glucose, and TG, which supported the hypothesis that regulation of bone remodeling, energy metabolism, and reproduction are linked.

Cited by 10 publications

References 25 publications

Male hypogonadism and pre-diabetes interplay: association or causal interaction? A systematic review

Male hypogonadism and pre-diabetes interplay: association or causal interaction? A systematic review

Association of serum testosterone with different classes of glucose metabolism and the mediation effect of obesity: The Henan Rural Cohort Study

The correlation between testosterone and stroke and the mediating role of blood pressure: The Henan rural cohort study

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