The correlation between testosterone and stroke and the mediating role of blood pressure: The Henan rural cohort study

Liu, Pengling; Wei, Dandan; Nie, Luting; Fan, Keliang; Xu, Qingqing; Wang, Lulu; Wang, Juan; Song, Yu; Wang, Mian; Liu, Xiaotian; Hou, Jian; Yu, Songcheng; Li, Linlin; Wang, Chongjian; Huo, Wenqian; Fan, Chengming; Mao, Zhenxing

doi:10.1016/j.jstrokecerebrovasdis.2022.106669

Cited by 4 publications

(1 citation statement)

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“…For example, commonly used hormones for the treatment of male infertility, such as follicle-stimulating hormone (FSH) ( 39 ), human chorionic gonadotropin (hCG) ( 40 ), and gonadotropin-releasing hormone (GnRH) ( 41 ), are utilized to stimulate the release of testosterone and the production of sperm. Considering the existing evidence suggesting a potential negative correlation between testosterone levels and the risk of stroke ( 42 , 43 ), it is plausible that hormones used for male infertility might have a potential effect in lowering the risk of stroke. Furthermore, adopting healthy lifestyle practices is an integral component of male infertility treatment.…”

Section: Discussionmentioning

confidence: 99%

Causal associations of male infertility with stroke: a two-sample Mendelian randomization study

Zhu,

Xin,

et al. 2024

Front. Endocrinol.

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BackgroundStroke is a devastating global health issue, with high mortality and disability rates. The increasing prevalence of male infertility among reproductive-aged men has become a growing concern worldwide. However, the relationship between male infertility and stroke incidence remains uncertain. This study aimed to address this knowledge gap by employing a Mendelian randomization (MR) approach.MethodUtilizing genetic instrumental variables derived from a genome-wide association study (GWAS) on male infertility and stroke, a two-sample MR design was implemented. Five different analysis methods, with inverse-variance weighted as the primary approach, were used to examine the genetic causal associations between male infertility and various stroke subtypes. Heterogeneity analysis, pleiotropy tests, and leave-one-out validation were conducted to assess heterogeneity, evaluate pleiotropy, and ensure the robustness of the findings.ResultThe results indicate a potential lower risk of small vessel stroke associated with male infertility (odds ratio, 95% confidence interval: 0.82, 0.68 to 0.99, p=0.044), although no significant impact on other stroke subtypes was observed. The study exhibited low heterogeneity and no apparent pleiotropy; however, the stability of the results was not optimal.ConclusionMale infertility might potentially confer a protective effect against small vessel stroke risk. Caution is warranted due to potential confounding factors. Additional studies are necessary to confirm these findings and provide further validation.

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