Testosterone augments FSH signaling by upregulating the expression and activity of FSH-Receptor in Pubertal Primate Sertoli cells

Bhattacharya, Indrashis; Basu, Sayon; Pradhan, Bhola Shankar; Sarkar, H. B. Devaraj; Nagarajan, Priyadharsini; Majumdar, Subeer S.

doi:10.1016/j.mce.2018.12.012

Cited by 31 publications

(16 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, these data are indicative of the link between the Gαs protein/cAMP/PKA-pathway to steroidogenesis, the latter being absent in Sertoli cells. Studies in primates revealed that FSH would act synergistically with testosterone (T) in priming the Sertoli cell response to endogenous stimuli that sustain spermatogenesis [19,20], indicating that the FSH-induced cAMP/PKA-pathway exerts a trophic [21], rather than steroidogenic function, which is committed to LH [22]. Moreover, pleiotropic coupling of the FSHR to other G proteins has been demonstrated [23]: for example, coupling of the FSHR to the Gαi protein is critically involved in Sertoli cell proliferation in the neonate rat [24].…”

Section: Fsh-induced Signaling Networkmentioning

confidence: 99%

FSH for the Treatment of Male Infertility

Casarini

Crépieux

Reiter

et al. 2020

IJMS

View full text Add to dashboard Cite

Follicle-stimulating hormone (FSH) supports spermatogenesis acting via its receptor (FSHR), which activates trophic effects in gonadal Sertoli cells. These pathways are targeted by hormonal drugs used for clinical treatment of infertile men, mainly belonging to sub-groups defined as hypogonadotropic hypogonadism or idiopathic infertility. While, in the first case, fertility may be efficiently restored by specific treatments, such as pulsatile gonadotropin releasing hormone (GnRH) or choriogonadotropin (hCG) alone or in combination with FSH, less is known about the efficacy of FSH in supporting the treatment of male idiopathic infertility. This review focuses on the role of FSH in the clinical approach to male reproduction, addressing the state-of-the-art from the little data available and discussing the pharmacological evidence. New compounds, such as allosteric ligands, dually active, chimeric gonadotropins and immunoglobulins, may represent interesting avenues for future personalized, pharmacological approaches to male infertility.

show abstract

Section: Fsh-induced Signaling Networkmentioning

confidence: 99%

FSH for the Treatment of Male Infertility

Casarini

Crépieux

Reiter

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…After activation, membrane-bound adenylate cyclase (AC) catalyzed the production of intracellular gproteins (e.g., stimulated gα), followed by an mediated pathway that stimulated multiple signal cascades. For example, PKA, PKC, PI3K, Akt / PKB and ERK1 / ERK2, to induce stem cell factor (SCF), glial-derived neurotrophic factor (GDNF) and androgen transcriptional binding protein (ABP) and transduction (TF) et al The synergy between FSH and T to maximize the spermatogenic output process, which plays a key role in the spermatogenesis process and male fertility [24]. In adult fertile men and women, FSH mediates spermatogenesis and follicular development through its G-protein coupled receptor (FSHR) [25].…”

Section: Discussionmentioning

confidence: 99%

Effect of Boschniakia Rossica Extract on BMP-5 and ActRIIA in Mice Model of Kidney-Yang Deficient

Mu¹,

Chen²,

Tian³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Boschniakia rossica (Cham. & Schltdl.) B. Fedtsch. (Bu-Lao-Cao in Chinese name) is a famous Chinese traditional drug and mainly distributed in Korea, Japan, Russia, and China. The dried whole grass of Boschniakia rossica is commonly used in traditional Chinese medicine to treat kidney deficiency, yang deficiency, waist and knee aches and constipation. In order to quantify the active ingredients in B. rossica chinensis and body weight, clinical features and serum SOD and MDA activities, cAMP, cGMP, and testosterone (T), follicle-stimulating growth hormone (FSH), mouse bone morphogenetic protein-5 (BMP-5), mouse activin receptor IIA (ActRIIA) were measured to elucidate the mechanism underlying its treatment of kidney yang deficiency potential. Methods Extracts of B. rossica were evaluated by HPLC-MS analyses. Kidney-yang deficiency syndrome was induced in mouse with hydrocortisone (10 mg/Kg, 15d) and treated with B. rossica extract. The animals were treated orally with 3 doses of B. rossica extract: 1000, 500 and 250 mg/Kg, for 15 days. Body weight and clinical characteristics were recorded daily. For biochemical analyses, the following tests were performed: superoxide dismutase (SOD) activity, malondialdehyde (MDA) activity, testosterone (T) content, follicle growth hormone (FSH) content, cyclic adenosine monophosphate (cAMP) content, mouse bone morphogenetic protein-5 (BMP-5) content and activin receptor IIA (ActRIIA) content. Results Our study found that all the mice except the blank group showed significant systemic depletion caused by hydrocortisone. Low T content, low cAMP activity and high cGMP content were consistent with the physiological and biochemical indexes of kidney-yang deficiency syndrome. After oral gavage, the pathological conditions were improved in both the Positive group and the B. rossica groups.Conclusions The high-dose extract of B. rossica showed similar therapeutic effects as Jingui Shenqi Pill. The extract of B. rossica can be used to treat with hydrocortisone-induced kidney yang deficiency syndrome by increasing serum testosterone content and decreasing FSH content. More importantly, the experiment found that activin A and BMP-5 also have effects on kidney yang deficiency syndrome.

show abstract

“…It was found that cAMP level was low in immature rat Sertoli cells. On the other hand, higher basal concentration of cAMP was observed in 20 days old Sertoli cells along with almost 4-fold increased activity of phosphodiesterase and completely abolished in older rat Sertoli cells (52)(53)(54)(55). Hence, it is assumed that diverse function of Sertoli cells in response to FSH might be responsible for robust onset of germ cell differentiation during prepubertal testicular maturation in rats.…”

Section: Follicle Stimulating Hormone (Fsh)mentioning

confidence: 99%

“…The synergistic actions of testosterone and FSH via testicular Sertoli cells regulate male fertility (53). FSH acts through receptors (FSHR) on the Sertoli cell to stimulate spermatogenesis while androgens promote testis growth through receptors (AR) on the Sertoli cells, Leydig cells and peritubular myoid cells.…”

Section: Androgensmentioning

confidence: 99%

“…Testosterone also augmented FSH induced expression of genes like SCF, GDNF, ABP and Transferrin. Such a coordinated network of hormonal signaling in Sertoli cells may facilitate the timely onset of the first spermatogenic wave in pubertal primates and is responsible for normal spermatogenesis (53). On the other hand, it has been reported that insufficient FSH and androgen are associated with azoospermia in infantile primate testes (98).…”

Section: Androgensmentioning

confidence: 99%

See 1 more Smart Citation

The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation

et al. 2021

View full text Add to dashboard Cite

Sustaining and maintaining the intricate process of spermatogenesis is liable upon hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli cells (SCs) are the major somatic cells present in the seminiferous tubules and are considered to be the main regulators of spermatogenesis. As each Sertoli cell supports a specific number of germ cells, thus, the final number of Sertoli cells determines the sperm production capacity. Similarly, sex hormones are also major regulators of spermatogenesis and they can determine the proliferation of Sertoli cells. In the present review, we have critically and comprehensively discussed the role of sex hormones and some other factors that are involved in Sertoli cell proliferation, differentiation and maturation. Furthermore, we have also presented a model of Sertoli cell development based upon the recent advancement in the field of reproduction. Hence, our review article provides a general overview regarding the sex hormonal pathways governing Sertoli cell proliferation and development.

show abstract

Testosterone augments FSH signaling by upregulating the expression and activity of FSH-Receptor in Pubertal Primate Sertoli cells

Cited by 31 publications

References 90 publications

FSH for the Treatment of Male Infertility

FSH for the Treatment of Male Infertility

Effect of Boschniakia Rossica Extract on BMP-5 and ActRIIA in Mice Model of Kidney-Yang Deficient

The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation

Contact Info

Product

Resources

About