The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation

Shah, Wasim; Khan, Ranjha; Shah, Basit; Khan, Asad; Dil, Sobia; Liu, Wei; Wen, Jie; Jiang, Xiaohua

doi:10.3389/fendo.2021.648141

Cited by 40 publications

(23 citation statements)

References 156 publications

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“…Hence, the female reproductive system study is mainly the study of the ovary and uterus [43,44]. e testes are vital organs that secrete male hormones and produce sperm, and the specific structures include the seminiferous tubules as well as the surrounding connective tissue [45]. In mammals, sperm need to pass through a special duct called the epididymis to mature and obtain fertilization ability after secretion from the testis [46].…”

Section: Discussionmentioning

confidence: 99%

Preparation and Safety Evaluation of Centella asiatica Total Glycosides Nitric Oxide Gel and Its Therapeutic Effect on Diabetic Cutaneous Ulcers

Liu

Zhang

Deng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Diabetic cutaneous ulcers (DCU) are a chronic and refractory complication of diabetes mellitus, which can lead to amputation or even death in extreme cases. Promoting the early healing of DCU and reducing the disability rate and treatment cost are important research topics in treating with integrated traditional Chinese and Western medicine. Centella asiatica total glycosides are extracted from the traditional Chinese medicine Centella asiatica and have angiogenic, anticancer, antioxidant, and wound healing effects. Nitric oxide (NO) is a critical component of wound healing. During the development of DCU, endogenous NO secretion is insufficient. It has been reported that exogenous nitric oxide can promote wound healing, but it is difficult to adhere to the skin because of its short half-life. Therefore, in this study, we used the polymer excipient hydroxyethyl cellulose as the matrix, combined with Centella asiatica total glycosides and NO, and developed a new type of topical gel that can promote wound healing. At the same time, we made a comprehensive research and evaluation on the preparation technology, quality standard, skin toxicity, reproductive toxicity, and pharmacodynamics against diabetic skin ulcers of the gel. According to our research results, the combination of Centella asiatica total glycosides and nitric oxide can accelerate the healing speed of DCU wounds, and 8% Centella asiatica total glycosides nitric oxide gel (CATGNOG) has the best effect in ulcer wound healing. CATGNOG has the advantages of feasible preparation method, controllable quality, good stability at low temperature, and no apparent skin toxicity and reproductive toxicity. It can effectively inhibit the growth of bacteria on the wound surface, relieve the inflammatory reaction of the wound surface, and promote the healing of ulcer wound, which provides a basis for further research of the preparation in the future.

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Section: Discussionmentioning

confidence: 99%

Preparation and Safety Evaluation of Centella asiatica Total Glycosides Nitric Oxide Gel and Its Therapeutic Effect on Diabetic Cutaneous Ulcers

Liu

Zhang

Deng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Around SC maturation, AR expression level is progressively upregulated until all SCs express AR (58). AR in SCs is key mediator for SC molecular and cytoskeleton maturation (59)(60)(61).…”

Section: Sertoli Cell Maturationmentioning

confidence: 99%

What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us?

Wang

Yang

2022

Front. Endocrinol.

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Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical signaling pathway. As the only somatic cell type in seminiferous tubule, Sertoli cells are under androgen receptor signaling pathway regulation via androgen receptor located in cytoplasm and plasma membrane. Androgen receptor signaling pathway is able to regulate biological processes in Sertoli cells as well as germ cells surrounded between Sertoli cells. Our review will summarize the major discoveries of androgen receptor signaling pathway in Sertoli cells and the paracrine action on germ cells. Androgen receptor signaling pathway regulates Sertoli cell proliferation and maturation, as well as maintain the integrity of blood-testis barrier formed between Sertoli cells. Also, Spermatogonia stem cells achieve a balance between self-renewal and differentiation under androgen receptor signaling regulation. Meiotic and post-meiotic processes including Sertoli cell - Spermatid attachment and Spermatid development are guaranteed by androgen receptor signaling until the final sperm release. This review also includes one disease related to androgen receptor signaling dysfunction named as androgen insensitivity syndrome. As a step further ahead, this review may be conducive to develop therapies which can cure impaired androgen receptor signaling in Sertoli cells.

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“…Testicular development is predominantly characterized by the development and differentiation of germ cells (GCs) and sertoli cells (SCs). 10 , 11 SCs are essential for spermatogenesis not only through direct interaction with GCs within the seminiferous epithelium but also by forming the blood-testis barrier (BTB) to provide morphological, nutritional, and immune support for GC development. 12 Notably, spermatogenesis is strictly regulated by the expression of stage-specific genes at both transcription and post-transcription levels.…”

Section: Introductionmentioning

confidence: 99%

MAEL gene contributes to bovine testicular development through the m5C-mediated splicing

Liu¹,

Ma²,

Wang³

et al. 2023

iScience

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The Molecular Mechanism of Sex Hormones on Sertoli Cell Development and Proliferation

Cited by 40 publications

References 156 publications

Preparation and Safety Evaluation of Centella asiatica Total Glycosides Nitric Oxide Gel and Its Therapeutic Effect on Diabetic Cutaneous Ulcers

Preparation and Safety Evaluation of Centella asiatica Total Glycosides Nitric Oxide Gel and Its Therapeutic Effect on Diabetic Cutaneous Ulcers

What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us?

MAEL gene contributes to bovine testicular development through the m5C-mediated splicing

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