Testing the role of the antioxidant uric acid as a biomarker of suicidal ideation in subjects with major affective disorders: An exploratory study

Bartoli, Francesco; Crocamo, Cristina; Trotta, Giulia; Bava, Mattia; Capuzzi, Enrico; Castagna, Gloria; Colzani, Lia Chiara; Malerba, Maria Rosaria; Clerici, Massimo; Carrà, Giuseppe

doi:10.1016/j.genhosppsych.2017.09.002

Cited by 10 publications

(11 citation statements)

References 12 publications

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“…Further investigation is warranted to validate this finding. Our results were in general agreement with previous research that revealed an inverse relationship between UA levels and suicidal ideation severity in patients with major affective disorders [25,26]. In addition, a decrease in the output of UA was also found in the urine of nonchemical suicide victims, although only 12 patients were included [40].…”

Section: Discussionsupporting

confidence: 92%

“…To date, few studies have been designed to explore the association between UA and suicide. Recently, promising findings from Bartoli and his team have shown an inverse relationship between UA levels and severity of suicidal ideation in individuals with major affective disorders [25,26] . However, some confounding factors such as glucose and lipid metabolism, renal function and prescribed medications were not controlled in these studies.…”

Section: Introductionmentioning

confidence: 99%

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Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Chen

Feng²,

Zhang

et al. 2020

BMC Psychiatry

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Background Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients. Methods One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured. Results Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients. Conclusion Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Chen

Feng²,

Zhang

et al. 2020

BMC Psychiatry

View full text Add to dashboard Cite

show abstract

“…Moreover, several potential confounders, such as variables associated with metabolism and renal function, were taken into account. Our results were in general agreement with previous research that revealed an inverse relationship between UA levels and suicidal ideation severity in patients with major affective disorders (Bartoli et al 2018c; Bartoli et al 2018d). In addition, a decrease in the output of UA was also found in the urine of nonchemical suicide victims, although only 12 patients were included (Lis et al 1975).…”

Section: Discussionsupporting

confidence: 93%

Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Chen

Feng²,

Zhang

et al. 2020

Preprint

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Background: Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients.Methods: One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured.Results: Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients.Conclusion: Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.

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“…Moreover, we did not evaluate circulating levels of various peptides or other molecules associated with inflammatory responses or stress, which can affect the metabolism of TRY and KYN [12] and may be altered in depression [34]. Finally, differences in the handling of biological samples, in association with differences in the biological half-life and chemical stability of analytes, can affect assay findings [4,15,40].…”

Section: Limitationsmentioning

confidence: 99%

Tryptophan and Kynurenine Metabolites: Are They Related to Depression?

et al. 2018

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Background: Some previous studies found decreased concentrations of L-tryptophan (TRY) and increased L-kynurenine (KYN), or its metabolites, in the body fluids of subjects with major depressive disorder (MDD), sometimes in association with suicidal behavior. Such changes might indicate a shift of TRY away from serotonin production, possibly via the effects of inflammatory peptides which activate indoleamine-2,3-dioxygenase. However, these findings have been inconsistent and require replication. Methods: We used sensitive liquid-chromatography mass spectrometry methods to assay plasma concentrations of TRY, 5-hydroxyindoleacetic acid (5-HIAA), and KYN and its metabolites (anthranilic acid and xanthurenic acid). We compared 49 hospitalized, depressed subjects diagnosed with MDD (n = 37) or bipolar disorder (BD, n = 12), with (n = 22) or without (n = 27) previous suicide attempts, to 78 healthy, ambulatory controls of similar age and sex (total n = 127). Findings: Contrary to expectation, TRY plasma concentrations were higher, KYN plasma concentrations were lower, and their ratio much higher in depressed subjects, with no relationship to suicidal history. Concentrations of 5-HIAA and the kynurenine metabolites did not differ between depressed and healthy subjects. Conclusions: These findings are opposite to expectations and not consistent with a hypothesized increased conversion from TRY to KYN in depressed subjects. In addition, we found no evidence of altered production of serotonin as 5-HIAA concentration was unchanged. None of the observed changes was associated with a history of suicide attempt.

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Testing the role of the antioxidant uric acid as a biomarker of suicidal ideation in subjects with major affective disorders: An exploratory study

Cited by 10 publications

References 12 publications

Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Tryptophan and Kynurenine Metabolites: Are They Related to Depression?

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