Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Chen, J; Feng, Jun-Hui; Zhang, Ligang; Liu, Yan; Yang, Fude; Wang, Shaoli; Tan, Yunlong; Su, Yun-Ai

doi:10.1186/s12888-020-02891-8

Cited by 15 publications

(12 citation statements)

References 54 publications

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“…The suicide risk section scores ranged from 0 to 33. As in our previous study, patients with a score <6 were classified as having non-suicidal risk, and those with a score ≥6 were classified as having suicidal risk ( 9 ), which includes suicide ideation, suicide act, or both. The 17-item Hamilton Depression Rating Scale (HAMD-17) was used to assess the severity of depressive symptoms ( 26 ).…”

Section: Methodsmentioning

confidence: 99%

“…Studies on factors leading to suicide have been undertaken for decades. The dimensions include but are not limited to genes, neuroanatomy, biochemistry, the environment, nutrition, physical and mental diseases, mainly depression, and alcohol abuse ( 2 , 5 – 9 ), but suicide prevention remains an area of uncertainty and needs further research ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Affective Temperaments and Suicide Risk in Patients With First-Onset Major Depressive Disorder

et al. 2022

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BackgroundPeople may endorse suicidal behavior during a major depressive episode. Affective temperaments may play a role in this risk. We explored the relationship between affective temperaments and suicide and identified some traits that can predict suicide risk in depression.Materials and MethodsWe analyzed the results of the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A) in 284 participants recruited from a psychiatric clinic and the community in Beijing and compared the subscale scores (temperaments of cyclothymic, dysthymic, anxious, irritable, and hyperthymic) among major depressive disorders (MDDs) vs. the general population as well as depressive patients with vs. without suicide risk, using Student’s test, chi-square test, rank-sum test, and multivariable regression modeling.ResultsThe incidence of suicidal risk in depressive subjects was 47.62% (80/168). Being unmarried (p < 0.001), unemployed (p = 0.007), and temperaments of dysthymic, cyclothymic, anxious, and irritable scores (all p < 0.001) were significantly more prevalent in patients with depression than in the general population. Young age (p < 0.001), female sex (p = 0.037), unmarried (p = 0.001), more severe depression (p < 0.001), and dysthymic, anxious, and cyclothymic temperament (all p < 0.05) were significantly more prevalent in patients with depressive disorder than those without suicide risk. The logistic regression analysis showed that younger age (odds ratio [OR] = 0.937, 95% CI 0.905∼0.970), female sex (OR = 2.606, 95% CI 1.142∼5.948), more severe depression (OR = 1.145, 95% CI 1.063∼1.234), cyclothymic temperament (OR = 1.275, 95% CI 1.102∼1.475), and dysthymic temperament (OR = 1.265, 95% CI 1.037∼1.542) were all independently associated with high suicidal risk in patients with first-onset major depression (p < 0.05).ConclusionTemperament traits differ between the general population and people suffering from MDD. Subjects with MDD who have much more severe depressive symptoms and a cyclothymic or dysthymic temperament were at a high risk of suicide.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship Between Affective Temperaments and Suicide Risk in Patients With First-Onset Major Depressive Disorder

et al. 2022

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“…All serum samples were obtained from the consenting volunteers. A smoker was defined as an individual who smoked either daily or occasionally in the 1 month preceding the time of survey [ 34 ]. Alcoholic consumption is often defined by whether or not drinking in the past year or six months or one month [ 35 ].…”

Section: Methodsmentioning

confidence: 99%

Associations of serum cystatin C with depressive symptoms and suicidal ideation in major depressive disorder

Sun

Chen

2021

BMC Psychiatry

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Background Individuals with major depressive disorder (MDD) have high suicidal ideation. There is evidence that serum cystatin C (Cys C) may be involved in the pathophysiology of MDD. The present study aimed to investigate Cys C concentration in patients with MDD and clarify its possible association with depressive symptoms and suicidal ideation. Methods An online cross-sectional survey of 159 patients diagnosed with MDD was conducted. Serum Cys C levels were measured using ADVIA 2400 biochemical analyzer. The 24-item Hamilton Depression Scale (HAMD-24) was administered to evaluate the depressive symptoms. Generalized linear regression, logistic regression and restricted cubic spline models were used to examine the association of serum Cys C levels with depressive symptoms and suicidal ideation. Results Serum Cys C levels were higher in MDD patients than in controls (p = 0.001) and were positively associated with scores on HAMD-24 in unadjusted (gender distribution, age, smoking, alcohol consumption, family history of depression and traumatic life events; (p = 0.003) and fully adjusted linear regression model (p = 0.005). The fully adjusted regression coefficient with 95% confidence intervals for serum Cys C levels and HAMD-24 score was 30.339 (9.602 to 51.077). The level of Cys C in the suicidal ideation (SI) group was significantly higher than that in the non-suicide ideation (non-SI) group (p = 0.001). Serum Cys C levels were positively associated with suicidal ideation in each logistic regression model (all p < 0.05). Conclusion Serum Cys C levels were elevated in MDD patients and appeared to be positively correlated with depressive symptoms and suicidal ideation. These findings suggest that the dysfunction of Cys C may be involved in the severity of depression and in the pathophysiological process of MDD. Thus, regulation of serum Cys C could potentially be an effective predictor of the severity of depression and potentially, play a role in reducing the risk of suicide in MDD patients.

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“…A previous study has suggested that uric acid levels are negatively associated with depressive symptoms, anxiety symptoms, and symptom duration 15 . Lower uric acid levels are also related to other psychiatric symptoms, such as higher suicide risk 23 . In the current study, the prevalence of depressive symptoms was signi cantly higher in women with relatively lower uric acid levels than in those with high uric acid levels.…”

Section: Discussionmentioning

confidence: 99%

Association between uric acid and depressive symptoms in older adults: The Korea National Health and Nutrition Examination Survey

Kim

Park

et al. 2022

Preprint

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Uric acid is known for its antioxidant capacity; however, whether uric acid is independently associated with depression in the older population remains controversial. The current study aimed to investigate the association between uric acid and depressive symptoms in older adults according to sex, using a large national sample population. Data from the 2016, 2018, and 2020 Korean National Health and Nutrition Examination Surveys were analyzed, and 5609 participants older than 60 years were included in this study. We defined a Patient Health Questionnaire-9 score ≥ 5 as indicating the presence of depressive symptoms. The prevalence of depressive symptoms was higher in women with lower uric acid levels than in those with higher uric acid levels. In women, uric acid was significantly associated with depressive symptoms in the multivariable logistic regression analysis (odds ratio, 1.36; 95% confidence interval, 1.10–1.68; p = 0.005). However, no significant association between uric acid levels and depressive symptoms was observed in men. The findings of this study suggest that uric acid is associated with depressive symptoms in older women, but not in men. Further research is needed on sex differences in the relationship between serum uric acid levels and depressive symptoms.

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Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Cited by 15 publications

References 54 publications

Relationship Between Affective Temperaments and Suicide Risk in Patients With First-Onset Major Depressive Disorder

Relationship Between Affective Temperaments and Suicide Risk in Patients With First-Onset Major Depressive Disorder

Associations of serum cystatin C with depressive symptoms and suicidal ideation in major depressive disorder

Association between uric acid and depressive symptoms in older adults: The Korea National Health and Nutrition Examination Survey

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