Testing for genetic structure in different urban Argentinian populations

Gender bias in the multiethnic genetic composition of central Argentina

“…As in Córdoba, all the above-mentioned studies clearly indicate directional mating in Argentina. Moreover, all these studies indicate Argentina shows a clear pattern of population substructure on the specific maternal and paternal genomes, which also corroborates the findings of previous studies based on autosomal STR markers (Toscanini et al 2006). The forensic field and medical genetic studies will benefit from population studies across the Argentinean territory that would allow detailed knowledge of population structure and its consequences when estimating the weight of forensic haploid evidence (Egeland and Salas 2008) or evaluating the possibility of spurious positive results in medical genetic studies .…”

Genetic variation and population structure of Sudanese populations as indicated by 15 Identifiler sequence-tagged repeat (STR) loci

“…One of the more common commercial sequence-tagged repeat (STR) kits available for human identity testing is the AmpFlSTR ® Identifiler™ PCR Amplification Kit (Applied Biosystems, Foster City, CA, USA), which includes the 13 core STR loci from the FBI Combined DNA Index System (CODIS), and two additional markers commonly used for forensic investigations in Europe. The marker panel has also been used in population structure and admixture studies of humans [16-21], and knowledge about population structure has contributed to our understanding of human origins [22]. Admixture or ancestry analysis is also important in forensics; for instance, to pinpoint an appropriate reference population for a particular case from which to compute match and exclusion probabilities, or to potentially get an indication of the perpetrator's ethnicity [23].…”

Population stratification in Argentina strongly influences likelihood ratio estimates in paternity testing as revealed by a simulation-based approach

“…Nevertheless, they found a clear statistical differentiation between the Salta population sample and the rest of the population samples analyzed, which contradict their final conclusion about the possibility of using a unique database for the whole country. Moreover, our previous findings [11] revealed the existence of population substructure in Argentina at autosomal STR level. In addition, population stratification is also supported when looking at the population patterns of Y-STR [23,24] and mitochondrial DNA data, as can be inferred from the few studies carried out in populations from this country [25][26][27][28].…”

“…It is well documented that in Argentina differences exist between allele frequency distributions in populations, for common genetic markers used in forensics, that can have important consequences in routine forensic casework [11,12]. This view, however, is controversial since other authors claim that population differences within the country are irrelevant in this context [13].…”