Gender bias in the multiethnic genetic composition of central Argentina

Salas, Antonio; Jaime, Juan Carlos; Álvarez-Iglesias, Vanesa; Carracedo, Ángel

doi:10.1007/s10038-008-0297-8

Cited by 64 publications

(61 citation statements)

References 49 publications

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“…Thus, unlike studies of Y and mitochondrial chromosomes in many other human populations, [47][48][49][50] the Hutterite male and female gene pools are similar with respect to genetic diversity and comparable with respect to their origins, suggesting a similar evolutionary history.…”

Section: Discussionmentioning

confidence: 54%

Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

et al. 2009

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Although the North American Hutterites trace their origins to South Tyrol, no attempts have been made to examine the genetic migration history of the Hutterites before emigrating to the United States in the 1870s. To investigate this, we studied 9 microsatellite loci and 11 unique event polymorphism (UEP) markers on the Y-chromosome, the hypervariable region I (HVRI) of the mitochondrial DNA (mtDNA), as well as the complete mtDNA genome of Hutterite and South Tyrolean samples. Only 6 out of 14 Y-chromosome UEP+microsatellite haplotypes and 3 out of 11 mitochondrial haplotypes that were present in the Hutterites were also present in the South Tyrolean population. The phylogenetic relationships inferred from Y-chromosome and mtDNA databases show that the Hutterites have a unique genetic background related to a similar extent to central and eastern European populations. An admixture analysis indicates, however, a relatively high genetic contribution of central European populations to the Hutterite gene pool. These results are consistent with historical records on Hutterite migrations and demographic history. In addition, our data reveal similar numbers of Y and mitochondrial haplotypes in Hutterite male and female founders, respectively. The Hutterite male and female gene pools are similar with respect to genetic diversity and genetic distance measures and comparable with respect to their origins, suggesting a similar evolutionary history.

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Section: Discussionmentioning

confidence: 54%

Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

et al. 2009

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“…It is noteworthy that most haplotypes (192; 95%) have not been reported earlier (Table 1). 27,39,[40][41][42] The haplotype diversity of the whole control region was 0.9945, with a mean number of pairwise differences of 11.14 and a nucleotide diversity of 0.0655 (see Table 2). Unlike HVR1, HVR2 had 15 sites that showed indels either as a singlepoint insertion (insertion at 180G) or as a part of polymorphic microsatellite (p248-249, p286-291, p303-309 and p311-315) and non-microsatellite (p106-111) tracts.…”

Section: Resultsmentioning

confidence: 99%

“…Considering only the positions at HVR1, this haplotype has been reported earlier once in Latin America. [40][41][42] Interestingly, the polymorphism A16183C was identified in all haplogroup B2 sequences. The haplogroup B2 in this study was further divided in two subgroups, based on transversion A16182C, which was found in 54.1% of the B2 haplotypes.…”

Section: Mitochondrial Haplogroupsmentioning

confidence: 99%

“…HVR1 polymorphisms found in haplotype Mx7 (11.1% of all haplotypes when only HVR1 were considered) have been reported earlier in other studies but in lower proportions (5-8%). [39][40][41][42] From 93 haplotypes that composed the haplogroup A2, 77 had a thymine at position 16111 and only 16 had the cytosine similar to the rCSR. Before the classification suggested by Bandelt, 26 haplogroup A was split into A1 and A2 by the transition at this position.…”

Section: Mitochondrial Haplogroupsmentioning

confidence: 99%

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A great diversity of Amerindian mitochondrial DNA ancestry is present in the Mexican mestizo population

et al. 2009

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There are limited data on mitochondrial DNA (mtDNA) variation in the Mexican mestizo population. To examine the genetic diversity and matrilineal ancestry, the full mtDNA hypervariable regions I and II were sequenced in 270 unrelated mestizos from different regions of Mexico. A total of 202 different haplotypes were identified and the haplotype diversity was 0.9945. Amerindian haplotypes predominated in the sample with a proportion of 93.3%, followed by European (6.0%) and African haplotypes (0.7%). The frequency of the Amerindian haplogroups A2, B2, C1 and D1 was 51.1, 17.8, 18.5 and 5.9%, respectively. The frequency of Amerindian haplogroups was higher in the central region than in Mexico City, whereas it was the contrary for European haplogroups. This difference was accounted principally by the high frequency of B2 haplotypes in the central region. The minimum spanning network, the mismatch distribution and Tajima's D neutrality test suggest a population expansion for each Amerindian haplogroup, which could be initiated more recently for haplogroups A2 and D1. The present knowledge combined with other nuclear genetic markers will be essential in future association studies to correct for genetic substructure in mestizo populations.

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“…To better evaluate the geographical distribution of the novel haplogroups, we surveyed published and unpublished CR data from a wide range of populations (Ginther et al 1993;Horai et al 1993;Alves-Silva et al 2000;Moraga et al 2000;Lalueza-Fox et al 2001;García-Bour et al 2004;Tajima et al 2004;Cabana et al 2006;Á lvarez-Iglesias et al 2007;Tamm et al 2007;Carvalho et al 2008;Salas et al 2008;Bobillo et al 2010;Catelli et al 2011;Gayà-Vidal et al 2011;Prieto et al 2011;Sans et al 2011;MC Bobillo, unpubl.). This allowed the identification of 103 putative D1g and D1j mtDNAs (Supplemental Table S3).…”

Section: Phylogeographic Patterns Of D1g and D1jmentioning

confidence: 99%

Rapid coastal spread of First Americans: Novel insights from South America's Southern Cone mitochondrial genomes

Bodner¹,

Perego²,

Huber³

et al. 2012

Genome Res.

170

169

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It is now widely agreed that the Native American founders originated from a Beringian source population ∼15–18 thousand years ago (kya) and rapidly populated all of the New World, probably mainly following the Pacific coastal route. However, details about the migration into the Americas and the routes pursued on the continent still remain unresolved, despite numerous genetic, archaeological, and linguistic investigations. To examine the pioneering peopling phase of the South American continent, we screened literature and mtDNA databases and identified two novel mitochondrial DNA (mtDNA) clades, here named D1g and D1j, within the pan-American haplogroup D1. They both show overall rare occurrences but local high frequencies, and are essentially restricted to populations from the Southern Cone of South America (Chile and Argentina). We selected and completely sequenced 43 D1g and D1j mtDNA genomes applying highest quality standards. Molecular and phylogeographic analyses revealed extensive variation within each of the two clades and possibly distinct dispersal patterns. Their age estimates agree with the dating of the earliest archaeological sites in South America and indicate that the Paleo-Indian spread along the entire longitude of the American double continent might have taken even <2000 yr. This study confirms that major sampling and sequencing efforts are mandatory for uncovering all of the most basal variation in the Native American mtDNA haplogroups and for clarification of Paleo-Indian migrations, by targeting, if possible, both the general mixed population of national states and autochthonous Native American groups, especially in South America.

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Gender bias in the multiethnic genetic composition of central Argentina

Abstract: A sample of central Argentina (Córdoba) was genotyped for the first hypervariable region (HVS

Cited by 64 publications

References 49 publications

Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes

A great diversity of Amerindian mitochondrial DNA ancestry is present in the Mexican mestizo population

Rapid coastal spread of First Americans: Novel insights from South America's Southern Cone mitochondrial genomes

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