2004
DOI: 10.1053/j.gastro.2004.03.012
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Testing for celiac sprue in irritable bowel syndrome with predominant diarrhea: A cost-effectiveness analysis☆

Abstract: Testing for CS in patients with IBS-D has an acceptable cost when the prevalence of CS is above 1% and is the dominant strategy when the prevalence exceeds 8%. The decision to test should be based on a consideration of the population prevalence of underlying CS, the operating characteristics of the screening test employed, and the cost of proposed therapy for IBS.

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Cited by 121 publications
(85 citation statements)
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References 39 publications
(58 reference statements)
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“…Several studies have shown that testing for CD in patients with IBS-type symptoms is likely to be cost-effective (20)(21)(22). Spiegel et al reported that histological testing for CD had an acceptable cost when CD prevalence was more than 1%, and became the dominant strategy, cheaper than empirical symptom-based therapy for presumed IBS, when the prevalence reached 8% (21).…”
Section: Discussionmentioning
confidence: 99%
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“…Several studies have shown that testing for CD in patients with IBS-type symptoms is likely to be cost-effective (20)(21)(22). Spiegel et al reported that histological testing for CD had an acceptable cost when CD prevalence was more than 1%, and became the dominant strategy, cheaper than empirical symptom-based therapy for presumed IBS, when the prevalence reached 8% (21).…”
Section: Discussionmentioning
confidence: 99%
“…Spiegel et al reported that histological testing for CD had an acceptable cost when CD prevalence was more than 1%, and became the dominant strategy, cheaper than empirical symptom-based therapy for presumed IBS, when the prevalence reached 8% (21). Another study reported that at a CD prevalence of 3% there was only a 1% increase in lifetime costs of managing IBS with tTG testing for CD, with the cost per quality adjusted life year falling to $4900 if the prevalence of CD in IBS was assumed to be 5% (20), close to the upper confidence limit of the estimate from our meta-analysis.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…96 These figures are comparable to the study by Mein and Ladabaum, 97 who found a prevalence of coeliac disease in irritable bowel syndrome of 3%, and concluded that testing for coeliac disease in patients with suspected IBS is likely to be costeffective. In another recent study, Spiegel and colleagues 98 found that testing for coeliac disease was likely to be cost-effective at a prevalence above 1%.…”
Section: Discussionmentioning
confidence: 99%
“…Según este Consenso, el escrutinio diagnóstico debe limitarse a ciertas pruebas de laboratorio (Tabla 1) y se debe realizar colonoscopia ante signos de alarma (pérdida de peso, hemorragia, anemia, fiebre, historia familiar de cáncer de colon o enfermedad inflamatoria intestinal), inicio de síntomas >50 años o cambio en el patrón de los síntomas 10 . Sólo se recomienda evaluación para enfermedad celíaca en regiones con una prevalencia mayor a 1% 11 .…”
Section: N V E S T I G a C I ó Nunclassified