Testing a Fine-Needle Optical Probe for Recording Changes in the Fluorescence of Coenzymes of Cellular Respiration

Kandurova, Ksenia; Potapova, Elena; Zherebtsov, Evgeny; Dremin, Viktor; Seryogina, Evgeniya; Vinokurov, Andrey Y.; Mamoshin, Andrian; Борсуков, А. В.; Ivanov, Yu. V.; Dunaev, Andrey V.

doi:10.1134/s0030400x20060089

Cited by 4 publications

(2 citation statements)

References 64 publications

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“…The efficiency of the system has been verified in Ref. 41 . The results of the previous study have demonstrated the ability of the probe to register the changes in fluorescence caused by the oxidative phosphorylation changes in biological tissues.…”

Section: Resultsmentioning

confidence: 97%

Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study

Dremin

Potapova

Zherebtsov

et al. 2020

Sci Rep

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This paper presents the results of the experiments which were performed using the optical biopsy system specially developed for in vivo tissue classification during the percutaneous needle biopsy (PNB) of the liver. The proposed system includes an optical probe of small diameter acceptable for use in the PNB of the liver. The results of the feasibility studies and actual tests on laboratory mice with inoculated hepatocellular carcinoma and in clinical conditions on patients with liver tumors are presented and discussed. Monte Carlo simulations were carried out to assess the diagnostic volume and to trace the sensing depth. Fluorescence and diffuse reflectance spectroscopy measurements were used to monitor metabolic and morphological changes in tissues. The tissue oxygen saturation was evaluated using a recently developed approach to neural network fitting of diffuse reflectance spectra. The Support Vector Machine Classification was applied to identify intact liver and tumor tissues. Analysis of the obtained results shows the high sensitivity and specificity of the proposed multimodal method. This approach allows to obtain information before the tissue sample is taken, which makes it possible to significantly reduce the number of false-negative biopsies.

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Section: Resultsmentioning

confidence: 97%

Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study

Dremin

Potapova

Zherebtsov

et al. 2020

Sci Rep

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“…Nowadays, light probes are successfully applied in semiconductor technology [1][2][3], surface physics [4][5][6], chemical detection [7][8][9], biological analysis [10][11][12], etc. More specifically, the surface and interface physics raised great interest in the optical characterization of layered systems [13][14][15] and molecular films [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

A microprocessor-aided platform enabling surface differential reflectivity and reflectance anisotropy spectroscopy

Bussetti

Ferraro

Bossi³

et al. 2021

Eur. Phys. J. Plus

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Surface differential reflectivity (SDR) and reflectance anisotropy spectroscopy (RAS) [sometimes known as reflectance difference spectroscopy] are two well-known optical spectroscopies used in the investigation of surfaces and interfaces. Their adaptability on different experimental conditions (vacuum, controlled atmosphere and liquid environment) allows for the investigation not only of surface states and/or ultra-thin films but also of more complex interfaces. In these circumstances, the analysis of the sample with both techniques is decisive in view of obtaining a correct picture of the sample optical properties. In this work, we show a microelectronic hardware solution useful to control both a SDR and a RAS apparatus. We describe an electronic architecture that can be easily replicated, and we applied it to a representative sample where the interpretation of the optical properties requires an analysis by both SDR and RAS. Graphic abstract

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Selection of characteristic wavelengths using SMA for laser induced fluorescence spectroscopy of power transformer oil

Dai

et al. 2023

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Testing a Fine-Needle Optical Probe for Recording Changes in the Fluorescence of Coenzymes of Cellular Respiration

Cited by 4 publications

References 64 publications

Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study

Optical percutaneous needle biopsy of the liver: a pilot animal and clinical study

A microprocessor-aided platform enabling surface differential reflectivity and reflectance anisotropy spectroscopy

Selection of characteristic wavelengths using SMA for laser induced fluorescence spectroscopy of power transformer oil

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