Testing a cumulative and aggregate exposure model using biomonitoring studies and dietary records for Italian vineyard spray operators

Kennedy, Marc C.; Glass, C. R.; Fustinoni, Silvia; Moretto, Angelo; Mandić‐Rajčević, Stefan; Riso, Patrizia; Turrini, Aida; Voet, Hilko van der; Hetmanski, Michel T.; Fussell, Richard J.; Klaveren, J.D. van

doi:10.1016/j.fct.2014.12.012

Cited by 13 publications

(19 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Modular descriptions of exposure pathways would allow use of individual modules as units of prediction (e.g., CalTox, IMPACT, USEtox), and the collection of modules for prediction of a full exposure pathway. Several research programs involve development of exposure modules that cover various elements of the AEP, such as near-field exposures during the use of consumer products. , In addition, construction of aggregate exposure models has been an active area of research outside of the U.S. Environmental Protection Agency and within the ecological/environmental fate and transport field, for pesticides and consumer products. − Development of these models can be viewed as an initial step toward construction of modular, predictive AEPs able to estimate exposures that, in turn, can be directly linked to hazard data and AOPs.…”

Section: Aggregate Exposure Pathway Applications In Environmental Healthmentioning

confidence: 99%

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework

Teeguarden

Tan

Edwards

et al. 2016

Environ. Sci. Technol.

104

100

View full text Add to dashboard Cite

Synopsis Driven by major scientific advances in analytical methods, biomonitoring, computational tools, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of observation to a field of prediction. Deployment of an organizational and predictive framework for exposure science analogous to the “systems approaches” used in the biological sciences is a necessary step in this evolution. Here we propose the Aggregate Exposure Pathway (AEP) concept as the natural and complementary companion in the exposure sciences to the Adverse Outcome Pathway (AOP) concept in the toxicological sciences. Aggregate exposure pathways offer an intuitive framework to organize exposure data within individual units of prediction common to the field, setting the stage for exposure forecasting. Looking farther ahead, we envision direct linkages between aggregate exposure pathways and adverse outcome pathways, completing the source to outcome continuum for more efficient integration of exposure assessment and hazard identification. Together, the two pathways form and inform a decision-making framework with the flexibility for risk-based, hazard-based, or exposure-based decision making.

show abstract

Section: Aggregate Exposure Pathway Applications In Environmental Healthmentioning

confidence: 99%

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework

Teeguarden

Tan

Edwards

et al. 2016

Environ. Sci. Technol.

104

100

View full text Add to dashboard Cite

show abstract

“…The lower yield achieved by some regions, such as Sub-Saharan Africa and the loss of almost 25% of food calories between the field and fork (Flood, 2010) indicate that the use of pesticides around the world will not be declining anytime soon. Controlling pesticide applicators' working conditions by environmental monitoring is hindered by the complexity of available methods, their price, but also poor reproducibility due to extreme variations in the climatic conditions, work modalities, available equipment, and use/nonuse/misuse of personal protective devices characterized by different levels of quality (Arbuckle et al, 2002;Mandic-Rajcevic et al, 2018, 2015. Biological monitoring, although more convenient, relies on the availability of biological exposure limits, which exist for several substances used in industrial settings but are lacking for pesticides.…”

Section: Discussionmentioning

confidence: 99%

Establishing health-based biological exposure limits for pesticides: A proof of principle study using mancozeb

Mandić‐Rajčević

Rubino

Colosio

2020

Regulatory Toxicology and Pharmacology

View full text Add to dashboard Cite

Pesticides represent an economical, labor-saving, and efficient tool for pest management, but their intrinsic toxic properties may endanger workers and the general population. Risk assessment is necessary, and biological monitoring represents a potentially valuable tool.Several international agencies propose biological exposure indices (BEI), especially for substances which are commonly absorbed through the skin. Biological monitoring for pesticide exposure and risk assessment seems a natural choice, but biological exposure limits (BEL) for pesticides are lacking.This study aims at establishing equivalent biological exposure limits (EBEL) for pesticides using real-life field data and the Acceptable Operator Exposure Level (AOEL) of mancozeb as the reference.This study included a group of 16 vineyard pesticide applicators from Northern Italy, a subgroup of a more extensive study of 28 applicators. Their exposure was estimated using "patch" and "hand-wash" methodologies, together with biological monitoring of free ethylene-bis-thiourea (ETU) excretion in 24-hour pre-and post-exposure urine samples.Modeling was done using univariate linear regression with ETU excretion as the dependent variable and the estimated absorbed dose as the independent variable.The median skin deposition of mancozeb in our study population was 125 µg, leading to a median absorbed dose of 0.9 µg/kg. The median post-exposure ETU excretion was 3.7 µg.The modeled EBEL for mancozeb was 148 µg of free ETU or 697 µg of total ETU, accounting for around 75% of the maximum theoretical excretion based on a mass balance model. Although preliminary and based on a small population of low-exposed workers, our results demonstrate a procedure to develop strongly needed biological exposure limits for pesticides..

show abstract

“…Having in mind that our attempt is the first step towards equivalent biological exposure limits for pesticides, additional uncertainty would decrease its value. This study also did not include a food consumption questionnaire, however, a cognate study had been carried out with a replicate diet and questionnaire to assess non-occupational exposure vs. occupational exposure to conazole fungicides, and the diet dose was less than 1% of the total dose of a worker working even in the conditions of best personal protection (Kennedy et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Establishing health-based Biological Exposure Limits for pesticides: a proof of principle study using Mancozeb

Mandić‐Rajčević¹,

Rubino²,

Colosio³

2020

Preprint

View full text Add to dashboard Cite

Pesticides represent an economical, labor-saving, and efficient tool for pest management, but their intrinsic toxic properties may endanger workers and the general population. Risk assessment is necessary, and biological monitoring represents a potentially valuable tool. Several international agencies propose biological exposure indices (BEI), especially for substances which are commonly absorbed through the skin. Biological monitoring for pesticide exposure and risk assessment seems a natural choice, but biological exposure limits (BEL) for pesticides are lacking. This study aims at establishing equivalent biological exposure limits (EBEL) for pesticides using real-life field data and the Acceptable Operator Exposure Level (AOEL) of mancozeb as the reference. This study included a group of 16 vineyard pesticide applicators from Northern Italy, a subgroup of a more extensive study of 28 applicators. Their exposure was estimated using "patch" and "hand-wash" methodologies, together with biological monitoring of free ethylene-bis-thiourea (ETU) excretion in 24-hour pre- and post-exposure urine samples. Modeling was done using univariate linear regression with ETU excretion as the dependent variable and the estimated absorbed dose as the independent variable. The median skin deposition of mancozeb in our study population was 125 μg, leading to a median absorbed dose of 0.9 μg/kg. The median post-exposure ETU excretion was 3.7 μg. The modeled EBEL for mancozeb was 148 μg of free ETU or 697 μg of total ETU, accounting for around 75% of the maximum theoretical excretion based on a mass balance model. Although preliminary and based on a small population of low-exposed workers, our results demonstrate a procedure to develop strongly needed biological exposure limits for pesticides.

show abstract

Testing a cumulative and aggregate exposure model using biomonitoring studies and dietary records for Italian vineyard spray operators

Cited by 13 publications

References 23 publications

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework

Establishing health-based biological exposure limits for pesticides: A proof of principle study using mancozeb

Establishing health-based Biological Exposure Limits for pesticides: a proof of principle study using Mancozeb

Contact Info

Product

Resources

About