Testicular Toxicity of Molinate in the Rat: Metabolic Activation via Sulfoxidation

Jewell, William T.; Hess, Rex A.; Miller, Marion G.

doi:10.1006/taap.1998.8380

Cited by 49 publications

(34 citation statements)

References 7 publications

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“…Our results showed tubules in both stages, before and after spermiation (VII-X), exhibiting elongated spermatids (step 19) in the tubular periphery. Similar alterations have been referred to as failure of spermatid release and phagocytosis by Sertoli cells [12,25,26]. Under normal conditions, spermiation occurs by the end of stage VIII, and step 19 spermatids rarely remain attached at stages IX-XI [9].…”

Section: Discussionmentioning

confidence: 88%

Morphological Alterations and Intratubular Lipid Inclusions as Indicative of Spermatogenic Damage in Cimetidine-Treated Rats

Sasso-Cerri¹,

Giovanoni²,

Hayashi³

et al. 2001

Archives of Andrology

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Doses of cimetidine (50 mg/kg b/w) were administered to adult male Wistar rats over 52 consecutive days. Besides plasma testosterone levels, morphological and morphometric aspects of the seminiferous tubules as well as histochemical analysis of the lipid content by oil red O were emphasized. Abnormal tubules exhibiting disorganization of their cellular association, loss of germ cells, and multinucleated giant spermatids were usually found. Significant reductions of testis weight and tubular diameter at specific stages (VII-IX), as well as lack of contact between Sertoli cells and spermatids in tubules at stage IX, suggest a possible interference of cimetidine on the histoarchitecture of the seminiferous epithelium. The dense concentration of lipid inclusions in tubules at postspermiation stages indicates phagocytosis and degradation of germ cells. Since no change in serum testosterone levels was verified in cimetidine-treated rats, the authors could not exclude the possibility that besides an antiandrogenic effect, other biochemical factors necessary for normal spermatogenesis could be involved in the testicular alterations.

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Section: Discussionmentioning

confidence: 88%

Morphological Alterations and Intratubular Lipid Inclusions as Indicative of Spermatogenic Damage in Cimetidine-Treated Rats

Sasso-Cerri¹,

Giovanoni²,

Hayashi³

et al. 2001

Archives of Andrology

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“…Although a testosterone assay was not performed, the necrosis of the interstitial cells probably would have resulted in decreased synthesis of this hormone, which is well known to support spermatogenesis [9]. …”

Section: Discussionmentioning

confidence: 99%

Testicular morphology and cauda epididymal sperm reserves of male rats exposed to Nigerian Qua Iboe Brent crude oil

2007

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Potential negative effects of exposure to Nigerian Qua Iboe Brent crude oil on the reproductive system of male rats was investigated. Forty Sprague-Dawley rats were used for the experiment. Exposure to Nigerian Qua Iboe Brent crude oil was achieved via oral administration of increasing doses (0.1, 0.2, and 0.4 ml/rat) every other day for 4 weeks. Cauda epididymal sperm reserves and relative weights of the testes as well as histological features of the testes of rats that received the crude oil treatment were compared to those of control rats. The results described here showed a significant (p < 0.01) dose-dependent reduction in the cauda epididymal sperm reserves of rats that received crude oil treatment relative to the control group. The morphology of testes of the crude oil-exposed rats was characterized by the presence of interstitial exudates, degeneration, and necrosis of spermatogenic and interstitial (Leydig) cells. Findings indicate that exposure of male rats to Nigerian Qua Iboe Brent crude oil may have adversely affected their reproductive systems. This may imply possible reproductive health hazards for animals and humans that may be exposed to this environmental pollutant, especially in areas where oil spillage is a common feature.

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“…Pflreger-Bruss et al (2004) ealier reported disruption in testosterone output with the administration of crude oil to rats. Jewell et al (1998) and Obidike et al (2007) have also reported degeneration and necrosis of the spermatogenic cells of the germinal epithelium of the seminiferous tubules with attendant decline in the CESR, when rats were experimentally treated with crude oil and they attributed it to oxidative stress. However, crude oil withdrawal initiated while vitamin E administration potentiated the 335 improvement in the CESR of the exposed rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of Vitamin E Supplementation in Male Rats with Crude Oil-Induced Reproductive Toxicity

et al. 2017

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Crude oil intoxication is a major threat among people and animals living around the crude oil producing regions of the world, hence the search for ameliorating agents. Forty-four male Wistar rats assigned to three groups were used to investigate the effects of vitamin E supplementation on crude oil-induced reprotoxicity (reproductive toxicity) in male rats. Group A represented the unexposed control, whereas groups B and C were exposed orally to 0.15 and 0.3 ml of crude oil respectively every other day, for 56 days. Both the low dose and high dose oral administration of crude oil caused a significant reduction in the serum testosterone level (STL) and cauda epididymal sperm reserve (CESR) of the exposed rats when compared to the control. Crude oil withdrawal and vitamin E supplementation significantly improved the cauda epididymal sperm reserve (CESR) in all the subgroups. The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities of the control and low dose group were significantly lower than those of the high dose group. The high dose crude oil administration significantly decreased the mean serum total protein (STP) and sodium ions (Na + ) concentration. The mean serum total cholesterol (STC) value of the low dose group was significantly higher than those of the control and high dose group. However, crude oil withdrawal and vitamin E supplementation did not significantly alter the mean serum total protein (STP) and mean serum total cholesterol (STC) values in all the subgroups. Vitamin E supplementation following low dose crude oil withdrawal enhanced the mean serum Chloride ions (Cl -) concentration. The present findings revealed that Nigerian Qua Iboe Brent crude oil induced serious reprotoxic effects in male rats which vitamin E administration within 28 days did not completely reverse.

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Testicular Toxicity of Molinate in the Rat: Metabolic Activation via Sulfoxidation

Cited by 49 publications

References 7 publications

Morphological Alterations and Intratubular Lipid Inclusions as Indicative of Spermatogenic Damage in Cimetidine-Treated Rats

Morphological Alterations and Intratubular Lipid Inclusions as Indicative of Spermatogenic Damage in Cimetidine-Treated Rats

Testicular morphology and cauda epididymal sperm reserves of male rats exposed to Nigerian Qua Iboe Brent crude oil

Effects of Vitamin E Supplementation in Male Rats with Crude Oil-Induced Reproductive Toxicity

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