Testicular metastasis from carcinoma of prostate: report of two cases

Abstract

Despite the high incidence of prostatic adenocarcinoma and its ability for wide dissemination, metastatic involvement of testis is rather uncommon. We report two cases (aged 76 and 55 years, respectively), where unilateral testicular metastasis was incidentally discovered after bilateral orchiectomy following detection of adenocarcinoma prostate in six-quadrant trucut specimen. Both patients had obstructive voiding symptoms, hard nodular prostate on direct rectal examination and raised serum prostate-specific antigen levels, without associated systemic or testicular symptoms. Extensive evaluation excluded any other possible primary, although axial skeletal metastasis was detected on radionucleotide bone scans, in the first case. These cases highlight the need for proper evaluation of testes and para-testicular structures, for accurate staging of these tumors and to exclude any possible metastasis.

Testicular Metastasis of Prostatic Adenocarcinoma after Ablatherm® Treatment

“…Furthermore, in most reported cases, the testicular lesion is not isolated. Nevertheless, infrequently, the testes or epididymis are the only site of metastasis [8]. In the present study, our patient presented a single metastatic site after treatment with HIFU.…”

Histopathological Analysis of Bilateral Orchiectomy Specimens in Prostatic Adenocarcinoma

“…Prostatic adenocarcinoma is one of the most frequently diagnosed cancer in adult males. The most common sites of the metastases are pelvic lymph nodes, bones, lungs and very rarely it can metastasizes into testis, breast, CNS or skin [1]. Metastasis in testis is generally seen incidentally in orchiectomy specimens performed for hormonal deprivation therapy with an incidence rate of about 2-4% [2].…”

Metastatic testicular and epididymal lesions in a patient with advanced prostate cancer: a case report and literature review

“…Ранее в отечественной литературе подобных сообщений представлено не было. Метастатическое поражение яичек встречается редко, чаще -у мужчин старше 60-70 лет с распространенными формами РПЖ и, как правило, является случайной находкой после двусторонней орхэктомии, выполненной в целях хирургической кастрации [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Ряд авторов описали симптоматические формы заболевания в виде увеличения, уплотнения мошонки и появления болезненности яичек [23][24][25][26][27][28][29][30][31][32][33].…”