Testicular histology and blood testosterone levels of male rabbit after given concentrated diets containing calliandra leaf meal and pineapple peels

Setyawati, Iriani; Ermayanti, Ni Gusti Ayu Manik; Suarni, Ni Made Rai; Narayani, Inna; Suaskara, Ida Bagus Made

doi:10.1088/1742-6596/983/1/012197

Cited by 1 publication

(4 citation statements)

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“…Spermatogenesis relies on the action of the hormone testosterone. Also, at puberty the initiation and maintenance of spermatogenesis throughout life is carried out by the testosterone (Setyawati et al, 2017). CONCLUSION This study suggested that PTZ induces testicular toxicity which led to disruption of the Leydig cells, which in turn caused decrease in the testosterone production.…”

Section: Discussionmentioning

confidence: 76%

“…The albumin-bound and the free portion are considered to be biologically active testosterone which act on target tissues, while the TeBG-bound fraction is tightly bound and is known to be not biologically active (Sherifa and Hamed 2016). Testosterone which is synthesizes in the Leydig cells play a key role in spermatogenesis and maturation of spermatozoa (Setyawati et al, 2017). The metabolism of the testosterone occurs is in the liver with dihydrotestosterone and estradiol (E 1 ) as the metabolites.…”

Section: Discussionmentioning

confidence: 99%

“…The metabolism of the testosterone occurs is in the liver with dihydrotestosterone and estradiol (E 1 ) as the metabolites. Increase in the serum level of E 1 is manifested with decrease in the erectile dysfunction and inhibition of gonadotropin LH due to hypogonadotropic hypogonadism (Setyawati et al, 2017). Also, deficiency of testosterone leads to decrease in libido and erectile dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…This implies that decrease in the serum testosterone level could lead a depletion in the 5-HT) content in the hypothalamus. Previous studies have revealed that PTZ cause production of reactive oxygen species (ROS) by generation of hydrogen peroxide, hydroxyl radicals and also decreasing the enzymatic antioxidant system capacity (Setyawati et al, 2017;Moa et al, 2019). LH hormone is responsible for stimulation of Leydig cells to synthesize testosterone.…”

Section: Discussionmentioning

confidence: 99%

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Ameliorative Potentials of Bombax costatum Pellegr. & Vuillet Chloroform Stem Bark Extract on Pentylenetetrazole-induced Testicular Damage in Wistar Rats

Wajauba¹,

Zirahei²,

Garba³

et al. 2022

AJBAR

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This study was conducted out to find out the ameliorative potentials of Bombax costatum Pellegr. & Vuillet chloroform extract (BCCE) on Pentylenetetrazole (PTZ)-induced testicular damage in albino Wistar rats. Eighteen adult rats were randomly allotted into three groups (n=6) after one week of acclimatization. Group one served as a control and was given normal saline. Group two (PTZ only) was given 35mgkg-1 body weight PTZ. Group three received BCCE 250mgkg-1 followed by PTZ 35mgkg-1, the treatments lasted for one week. The rats were euthanized and testicular tissues were processed for histological study, while blood samples were collected and used for the hormonal assay. The interstitial Leydig cells have been disrupted by the PTZ toxicity which resulted in a significant decrease (p<0.05) of testosterone in the PTZ-induced rats as compared with the control group, while there was no significant difference in group three that was given BCCE when compared to the control. Also, there was no significant difference in the luteinizing hormone (LH) and follicles stimulating hormones (FSH) levels in all the rat groups. The histological features showed that PTZ has a deleterious effect on testicular tissues with seminiferous tubule lumen devoid of spermatozoa. The histology of the group that received BCCE 250mgkg-1 shows the lumen of the seminiferous tubules with spermatozoa indicating that BCCE exerts a protective effect against PTZ-induced damage. This suggests that BCCE has an ameliorative effect against PTZ-induced testicular toxicity in rat models.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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