Testicular cancer in Down syndrome with spinal cord metastases

Abstract

A 22-year-old male patient with Down syndrome was referred to our hospital with a vast left testicular mass. He underwent a left radical inguinal orchiectomy, and a histopathological examination of the mass showed a yolk sac tumor invading the epididymis. The patient was discharged in a satisfactory condition. Sixteen days later, the patient presented again complaining of lower limb weakness. Magnetic resonance imaging of the spine showed metastatic lesions compressing the dorsal spine, and he underwent emergency surgical decompression. The histopathology of the metastatic lesions revealed a yolk sac subtype which was identical to his primary testicular tumor.

Metastatic Testicular Seminoma in a Patient With Down Syndrome Presenting As Extensive Deep Venous Thrombosis

“…A painless testicular mass is the most common first presenting sign in otherwise healthy patients. Atypical presenting symptoms of testicular cancer such as unexplained deep vein thrombosis (DVT) may occur in patients with cognitive impairment or those in a non-verbal state; these symptoms may be the only clue to diagnosis [ 3 ]. Failure of patients to express early symptoms may lead to delayed diagnosis and poor outcomes.…”

Testicular yolk sac tumour metastasis to the L2 vertebra

“…The adjuvant surgical management of vertebral body metastases from yolk sac tumours has not been established, as chemotherapy is the main treatment for disseminated disease 1 3 5. However, in the presence of neurological deficits, surgery and radiotherapy can be added to control the disease and improve neurological function 7. This report describes a patient who developed an asymptomatic yolk sac metastasis to the L2 vertebra, unresponsive to chemotherapy and conventional radiotherapy.…”