Test Performances of Three Diagnostic Procedures in Evaluating Thyroid Nodules: Physical Examination Ultrasonography and Fine Needle Aspiration Cytology.

Okamoto, Takahiro; Yamashita, Tomoyuki; Harasawa, Arimi; Kanamuro, Toshiko; Aiba, Motohiko; Kawakami, Makio; Ito, Yukio; Murakami, M.; Fujimoto, Yoshihide; Obara, Takao

doi:10.1507/endocrj.41.243

Cited by 31 publications

(18 citation statements)

References 14 publications

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“…The results of sonography and color duplex examination in differentiation of benign from malignant thyroid nodules have a sensitivity ranging from 63% to 87%, a specificity from 61% to 95%, and an overall accuracy from 80% to 95%. 11,12 The FNAB is reported to have a sensitivity ranging from 65% to 98% and a specificity of 72%-100%. 13,14 In this study, we applied an echo-planar MR imaging type of diffusion imaging with b-values of 0, 250, and 500 s/mm 2 , which were sufficient to obtained high image quality and a high sensitivity for diagnosis of thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

“…5 FNAB is considered an effective method for differentiating between benign and malignant thyroid nodules. 4,7,[12][13][14] Routine T1-and T2-weighted MR imaging has a limited role in the evaluation of thyroid nodules. It cannot distinguish benign from malignant nodules or assess the functional status of thyroid nodules.…”

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confidence: 99%

“…It cannot distinguish benign from malignant nodules or assess the functional status of thyroid nodules. [12][13][14][15] Diffusion-weighted MR imaging has been used to characterize head and neck tumors, in which there are significant differences in the apparent diffusion coefficient (ADC) values of malignant tumors and benign lesions. [16][17][18][19] Tezuka et al, 20 in their study using diffusion-weighted MR imaging to assess the thyroid function, reported that the ADC values of patients with Grave's disease exceeded those of patients with subacute thyroiditis, with a sensitivity and specificity of 75% and 80%, respectively, in differentiating between both disease entities.…”

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confidence: 99%

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Role of Apparent Diffusion Coefficient Values in Differentiation Between Malignant and Benign Solitary Thyroid Nodules

Razek

Sadek²,

Kombar³

et al. 2007

AJNR Am J Neuroradiol

108

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Role of Apparent Diffusion Coefficient Values in Differentiation Between Malignant and Benign Solitary Thyroid Nodules

Razek

Sadek²,

Kombar³

et al. 2007

AJNR Am J Neuroradiol

108

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“…Atribuímos estes resultados a experiência do citopatologista que analisou as punções dos pacientes hipercalcitoninêmicos. Entretanto, quando consideramos a amostra como um todo, a acurácia deixa bastante a desejar, revelando uma sensibilidade de apenas 44,4% (4/9), inferior aquela encontrada na literatura (33,37,38,39) e inclusive aquela encontrada no Departamento de Patologia da USP, cuja acuracidade é de 97,2 %. (12).…”

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Abordagem clínica e laboratorial do bócio uninodular sólido: vantagens da determinação da calcitonina sérica por métodos distintos no rastreamento do carcinoma medular de tireóide, forma esporádica

Abelin

Gomes

Ivanoff

et al. 1999

Arq Bras Endocrinol Metab

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RESUMOA apresentação clínica mais freqüente da forma esporádica do carcinoma medular da tireóide (CMT) é o bócio uninodular sólido (BUS), apresentação esta semelhante aos demais tumores que afetam a glândula. O estabelecimento da freqüência de CMT em BUS apresenta implicações importantes não só diagnosticas, como também terapêuticas, visto a abordagem cirúrgica do CMT diferir de outros tumores tireoideanos. Para investigar a prevalência de CMT em BUS, dosamos calcitonina (CT) sérica, marcador bioquímico do CMT, por métodos distntos (RIA e IRMA) em 60 casos (55 mulheres; com idades entre 22 e 75 anos). A análise citológica obtida através de punção biópsia (PAAF) revelou 100% de especificidade e 67% de sensibilidade na detecção de carcinoma de tireóide. Considerando-se o grau de suspeita clínica para neoplasia tireoideana e os achados anatomopatológicos, houve 60% de correlação positiva. CMT foi diagnosticado através da elevação da CT sérica em um dos 59 casos (1,69%) e confirmado posteriormente pela PAAF e anatomopatológico. A incidência de CMT entre os casos de neoplasias tireoideanas nesta amostra foi de 12,5% (1/8). Concluímos que a dosagem rotineira da CT séri-ca em casos com BUS não só complementa o estudo desta doença, como auxilia fortemente no diagnóstico do CMT. Tanto o IRMA como o RIA mostraram-se métodos úteis no rastreamento do CMT. Entretanto, o RIA pode provavelmente detectar ainda mais precocemente a elevação de formas não monoméricas da molécula de CT, as quais nos casos de CMT são usualmente mais abundantes que as formas monoméricas. (Arq Bras Endocrinol Metab 1999;43/2: 104-13).Unitermos: Tireóide; Calcitonina; Bócio uninodular atóxico; Carcinoma medular de tireóide. ABSTRACTSporadic medullary thyroid carcinoma (MTC) usually presents as a single nodule (SNT), a presentation common to other thyroid tumors. The establishment of its frequency in SNT has diagnostic and therapeutic implications, since surgery for MTC differs from other tumors. Serum calcitonin (CT), the standard marker for MTC, were measured in 60 cases of SNT (55 females, 22-75 years of age). Fine needle aspiration biopsy (FNAB) of the nodules was also performed, being 100% specific and 67% sensitive for detecting thyroid carcinomas. Sixty percent of clinically suspected malignancies were confirmed post-surgically. MTC was diagnosed by serum CT in 1 of 59 cases (1.69%), confirmed by FNAB and submitted to appropriate surgery. It accounted for 12.5% of thyroid malignancies of this group, since 6 papillary and 1 undifferentiated cases were also diagnosed. Therefore, routine serum CT measurement in SNT is a strong tool in the diagnosis and adequate surgery of MTC. Both IRMA and RIA were useful in this screening. The latter, however, can detect MTC earlier, due to its ability to measure non-monomeric forms of CT, abundant in this condition. (Arq Bras Endocrinol Metab 1999;43/2: 104-13).

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“…(papillary carcinoma, 392; follicular carcinoma, 28; other malignancies, 31); and benign tumor, 322 [3]. The patients' records were reviewed and evaluated for eligibility; therefore, the sampling was nonrandom.…”

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Measuring Serum Thyroglobulin in Patients with Follicular Thyroid Nodule: Its Diagnostic Implications.

et al. 1997

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Abstract.To The diagnostic value of serum Tg was examined by means of receiver operating characteristic (ROC) curves. There were significant correlations between the serum Tg level and the maximum diameter of the nodule, the macroscopic characteristics, and the smoking habit. The sensitivity and specificity of the serum Tg level with a cut-off value of 1,000 µg/1 were 57% and 86%, respectively.The likelihood ratio favouring follicular carcinoma associated with the serum Tg > 1,000 µg/l was 4.41. Measuring the level of serum Tg may be useful in discriminating follicular carcinoma from follicular adenoma, but since there may be some biases in this retrospective study, the results are less definitive. Further research activities are mandatory to obtain valid evidence.

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Test Performances of Three Diagnostic Procedures in Evaluating Thyroid Nodules: Physical Examination Ultrasonography and Fine Needle Aspiration Cytology.

Abstract: Abstract.A retrospective study was performed to determine the reliability of physical examination

Cited by 31 publications

References 14 publications

Role of Apparent Diffusion Coefficient Values in Differentiation Between Malignant and Benign Solitary Thyroid Nodules

Role of Apparent Diffusion Coefficient Values in Differentiation Between Malignant and Benign Solitary Thyroid Nodules

Abordagem clínica e laboratorial do bócio uninodular sólido: vantagens da determinação da calcitonina sérica por métodos distintos no rastreamento do carcinoma medular de tireóide, forma esporádica

Measuring Serum Thyroglobulin in Patients with Follicular Thyroid Nodule: Its Diagnostic Implications.

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