Terrein performs antitumor functions on esophageal cancer cells by inhibiting cell proliferation and synergistic interaction with cisplatin

Abstract

Abstract.Terrein is a bioactive fungal metabolite isolated from Aspergillus terreus. Besides being a melanogenesis inhibitor, previous studies have revealed that terrein has antiproliferative effects on a number of types of cancer tumors. In the present study, the inhibitory effect of terrein on esophageal cancer was evaluated and the possible underlying mechanisms were investigated. The results revealed that terrein inhibited the proliferation of Eca109 esophageal cancer cells in a dose-and time-dependent manner. Mechanistically, terrein treatment led to the G 2 /M phase arrest of Eca109 cells by indirectly regulating cyclin B1 and phosphorylating the cell division cycle protein 2 genes. Notably, terrein exhibited a synergistic effect on Eca109 cells when combined with cisplatin, which is a commonly used chemotherapeutic drug. Taken together, these findings indicate that terrein suppresses the proliferation of esophageal cancer cells, and may prove to be a novel therapeutic approach for the treatment of esophageal cancer via inhibiting the proliferation of cancer cells.

Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa: a connection between quorum sensing and c-di-GMP

“…Terrein has been reported to possess certain biological activities, such as anti-melanogenesis 39 , an anti-proliferative effect in human cancer cells 40 and an anti-inflammatory effect in human gingival fibroblasts 18 . Mechanistically, terrein has been reported to show anti-cancer activity in human cancer cells by inducing apoptosis and cell cycle arrest 40 , 41 , and, to my knowledge, a general toxicity of terrein has not been reported. However, the anti-virulence activity of terrein against bacteria is reported for the first time in this study.…”

Synergistic antitumor effects of the combined treatment with an HDAC6 inhibitor and a COX-2 inhibitor through activation of PTEN

“…AB is the OD 450 ratio of the two-drug combination group to the control group; A and B are the OD 450 ratios of each of the single-drug groups to the control group. CDI <1 indicates a synergistic effect, CDI <0.7 indicates a significant synergistic effect, CDI =1 indicates additivity, and CDI >1 indicates antagonism ( 31 ).…”

Recent Advances in Isolation, Synthesis and Biological Evaluation of Terrein

“…[55][56][57][58][59] Notably, terrein exhibited a synergistic effect on Eca109 cells when combined with cisplatin, which was a commonly used chemotherapeutic drug. [60]…”

“…It was considered as an important marker gene for cancer stem cells and a potential target for ovarian cancer treatment [55–59] . Notably, terrein exhibited a synergistic effect on Eca109 cells when combined with cisplatin, which was a commonly used chemotherapeutic drug [60] …”