Terpyridine copper(ii) complexes as potential anticancer agents by inhibiting cell proliferation, blocking the cell cycle and inducing apoptosis in BEL-7402 cells

Abstract

Four mononuclear terpyridine complexes [Cu(H-La)Cl2]·CH3OH (1), [Cu(H-La)Cl]ClO4 (2), [Cu(H-Lb)Cl2]·CH3OH (3), and [Cu(H-Lb)(CH3OH)(DMSO)](ClO4)2 (4) were prepared and fully characterized. Complexes 14 exhibited higher cytotoxic activity against several tested cancer cell lines...

Synthesis and anticancer mechanisms of zinc(ii)-8-hydroxyquinoline complexes with 1,10-phenanthroline ancillary ligands

“…The role played by Ca 2+ levels in cell apoptosis was examined using a fluorescent probe (Fluo-3Am) via flow cytometry. 43 To study the efflux of intracellular Ca 2+ induced by DQ6 (2.25 μM) and DQ11 (10.39 μM) over 24 h, we used Fluo-3Am as a special dye for determining intracellular Ca 2+ . The fluorescence intensity of SK-OV-3CR cells in the DQ6 - and DQ11 -groups was significantly enhanced (32.79 ± 0.78% and 21.28 ± 0.25%, respectively), indicating a notable increase in the intracellular Ca 2+ concentration (Fig.…”

Synthesis, characterization and biological activity of novel copper complexes containing a β-carboline derivative and amino acids

“…The annexin V-FITC/PI double staining assay was used to further investigate the mechanism of apoptosis induced by these Cu( ii ) complexes. 40 It determines the cell state by the change in the permeability and integrity of the cell membrane. 41 As can be observed in Fig.…”

Potential of Copper and Copper Compounds for Anticancer Applications

“…Gu et al prepared four terpyridine copper(II) complexes ( Figure 6 C), which exhibited higher cytotoxic activity against several tested cancer cell lines, especially BEL-7402 cells. They showed low toxicity to normal human liver cells [ 69 ]. Mechanistic studies have shown that copper complexes can induce G0/G1 phase arrest and alter the expression of cell cycle-related proteins.…”