Terpenes solubility in water and their environmental distribution

Martins, Mónia A.R.; Silva, Liliana P.; Ferreira, Olga; Schröder, Bernd; Coutinho, João A. P.; Pinho, Simão P.

doi:10.1016/j.molliq.2017.06.099

Cited by 62 publications

(39 citation statements)

References 42 publications

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“…According to the Amoore-Buttery equation, K aw = 8.08 × 10 −5 . This value of K aw for Eugenol agrees well with that obtain experimentally ( 43 ).…”

Section: Methodssupporting

confidence: 91%

Zinc Nanoparticles Enhance Brain Connectivity in the Canine Olfactory Network: Evidence From an fMRI Study in Unrestrained Awake Dogs

et al. 2018

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Prior functional Magnetic Resonance Imaging (fMRI) studies have indicated increased neural activation when zinc nanoparticles are added to odorants in canines. Here we demonstrate that zinc nanoparticles up-regulate directional brain connectivity in parts of the canine olfactory network. This provides an explanation for previously reported enhancement in the odor detection capability of the dogs in the presence of zinc nanoparticles. In this study, we obtained fMRI data from awake and unrestrained dogs while they were being exposed to odorants with and without zinc nanoparticles, zinc nanoparticles suspended in water vapor, as well as just water vapor alone. We obtained directional connectivity between the brain regions of the olfactory network that were significantly stronger for the condition of odorant + zinc nanoparticles compared to just odorants, water vapor + zinc nanoparticles and water vapor alone. We observed significant strengthening of the paths of the canine olfactory network in the presence of zinc nanoparticles. This result indicates that zinc nanoparticles could potentially be used to increase canine detection capabilities in the environments of very low concentrations of the odorants, which would have otherwise been undetected.

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“…According to the Amoore-Buttery equation, K aw = 8.08 × 10 −5 . This value of K aw for Eugenol agrees well with that obtain experimentally ( 43 ).…”

Section: Methodssupporting

confidence: 91%

Zinc Nanoparticles Enhance Brain Connectivity in the Canine Olfactory Network: Evidence From an fMRI Study in Unrestrained Awake Dogs

et al. 2018

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“…Terpenes, along with their derivatives called terpenoids, form a very large group of chemical compounds obtained mainly from plants. Up to now, more than 55,000 substances of this type have been discovered [1][2][3]. Due to their numerous and varied health properties, terpenes with terpenoids are of interest of many scientists.…”

Section: Phenolic Terpenoids: Eugenol Carvacrol and Thymolmentioning

confidence: 99%

“…DP voltammograms of the analyzed phenolic terpenoids, obtained for 7.40 mg/dm 3 of eugenol, 5.55 mg/dm 3 of carvacrol, and 4.10 mg/dm 3 of thymol in 0.1 mol/dm3 acetate buffer pH 6.0; without background subtraction (raw data). b Univariate calibration relation for 0.39-14.63 mg/dm 3 of eugenol.…”

mentioning

confidence: 99%

Multivariate approach in voltammetric identification and simultaneous determination of eugenol, carvacrol, and thymol on boron-doped diamond electrode

Kowalcze

Jakubowska

2019

Monatsh Chem

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The paper presents multivariate partial least-squares calibration model defined for the identification and simultaneous determination of phenolic terpenoids-eugenol, carvacrol, and thymol-by means of the differential pulse voltammetry. For the first time, using boron-doped diamond electrode signal, electrochemical distinction of carvacrol and thymol, despite the short distance between the peaks (15 mV), was described. The analytes' concentrations applied in the calibration model were selected using the 3-factorial central composite design. The multivariate partial least-squares model, with optimized data pre-processing, was used for determination of eugenol, carvacrol, and thymol in the concentration ranges of 0.77-13.86, 0.58-10.40, and 0.73-7.32 mg/dm 3 , respectively. The quality of the method, expressed by the root-mean-squared error of calibration was 0.55, 0.20, and 0.26 mg/dm 3 for the specified analytes. The recovery in the analysis of the pure signals was 98.92%, 101.62%, and 101.46%, what confirmed the possibility of clearly distinguishing the thymol and carvacrol peaks. In the spiked honey samples, the accuracy of eugenol, carvacrol, and thymol determination, expressed by the root-meansquared error of prediction, was in the range 0.20-0.83 mg/dm 3 , and recovery in the range 80.9-111.9%. Application of the presented model not only enables electrochemical identification and simultaneous determination of eugenol, carvacrol, and thymol, but also allows rapid, accurate, and low-cost verification of authenticity of the commercial products.

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“…EOs are volatile aromatic liquids and complex plant materials known for their medicinal properties, such as analgesia, sedation, anti-inflammatory, spasmolytic, and local anesthetic activities. The main groups of EOs are terpenes, such as carvacrol and thymol, and terpenoids, comprised of menthol and other aromatic and aliphatic components, such as eugenol and chavicol (14)(15)(16)(17)(18). Regarding toxicity, since these compounds are lipophilic, EOs readily cross plasma membranes and cell walls, and they may disrupt essential components of cells and bacteria.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity and toxicity of glass ionomer cement containing an essential oil

Nunes

Farias

Vieira

et al. 2020

Braz J Med Biol Res

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The aim of this study was to evaluate the antimicrobial activity and toxicity of glass ionomer cement (GIC) modified with 5methyl-2-(1-methylethyl)phenol (thymol) against Streptococcus mutans in silico and in vitro. The antimicrobial activity of thymol on GIC modified with concentrations of 2% (GIC-2) and 4% (GIC-4) was evaluated in a model of planktonic cell biofilm using agar diffusion test, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), dynamic biofilm (continuous flow cell parallel), and bacterial kinetics. Conventional GIC (GIC-0) was used as a control. Thymol toxicity was evaluated in Artemia salina and in silico using Osiris s software. Differences between groups were estimated by analysis of variance, followed by Tukey post hoc test, with a 5% significance level. The results of the agar diffusion test between groups were not significantly different (PX0.05). Thymol had potential bacteriostatic and bactericidal activity against Streptococcus mutans with respect to planktonic growth, with MIC of 100 mg/mL and MBC of 400 mg/mL. The groups GIC-0, GIC-2, and GIC-4 reduced the biofilm by approximately 10, 85, and 95%, respectively. Bacterial kinetics showed efficiency of the modified GICs for up to 96 h. GIC with thymol was effective against S. mutans, with significant inhibition of the biofilms. Analyses in silico and using Artemia salina resulted in no relevant toxicity, suggesting potential for use in humans. GIC-2 was effective against S. mutans biofilm, with decreased cell viability.

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Terpenes solubility in water and their environmental distribution

Cited by 62 publications

References 42 publications

Zinc Nanoparticles Enhance Brain Connectivity in the Canine Olfactory Network: Evidence From an fMRI Study in Unrestrained Awake Dogs

Zinc Nanoparticles Enhance Brain Connectivity in the Canine Olfactory Network: Evidence From an fMRI Study in Unrestrained Awake Dogs

Multivariate approach in voltammetric identification and simultaneous determination of eugenol, carvacrol, and thymol on boron-doped diamond electrode

Antimicrobial activity and toxicity of glass ionomer cement containing an essential oil

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