Ternary blend nanofibres of poly(lactic acid), polycaprolactone and cellulose acetate butyrate for skin tissue scaffolds: influence of blend ratio and polycaprolactone molecular mass on miscibility, morphology, crystallinity and thermal properties

Tuancharoensri, Nantaprapa; Ross, Gareth; Mahasaranon, Sararat; Topham, Paul D.; Ross, Sukunya

doi:10.1002/pi.5393

Cited by 29 publications

(27 citation statements)

References 42 publications

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“…The material blends' miscibility is often enhanced with a plasticiser, which is often organic. Ternary blend scaffold materials that are micro-to nanocellulose-based with polylactic acid, chitin, and starch are most common because of their compatibility with the human system [191]. These blends have been used for skin tissue repair.…”

Section: Micro-and Nanocellulose-based Ternary Blends Scaffoldmentioning

confidence: 99%

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

et al. 2020

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Biopolymers have been used as a replacement material for synthetic polymers in scaffold forming due to its biocompatibility and nontoxic properties. Production of scaffold for tissue repair is a major part of tissue engineering. Tissue engineering techniques for scaffold forming with cellulose-based material is at the forefront of present-day research. Micro- and nanocellulose-based materials are at the forefront of scientific development in the areas of biomedical engineering. Cellulose in scaffold forming has attracted a lot of attention because of its availability and toxicity properties. The discovery of nanocellulose has further improved the usability of cellulose as a reinforcement in biopolymers intended for scaffold fabrication. Its unique physical, chemical, mechanical, and biological properties offer some important advantages over synthetic polymer materials. This review presents a critical overview of micro- and nanoscale cellulose-based materials used for scaffold preparation. It also analyses the relationship between the method of fabrication and properties of the fabricated scaffold. The review concludes with future potential research on cellulose micro- and nano-based scaffolds. The review provides an up-to-date summary of the status and future prospective applications of micro- and nanocellulose-based scaffolds for tissue engineering.

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Section: Micro-and Nanocellulose-based Ternary Blends Scaffoldmentioning

confidence: 99%

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

et al. 2020

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“…One of the most popular processes for the fabrication of tissue engineering scaffolds is electrospinning, which produces nanofibers of large surface area and porous structure that can be designed to be similar to the extracellular matrix. This enables the enhancement of cell adhesion, proliferation and migration . Generally, SS has poor spinnability unless it is combined with another highly spinnable polymer .…”

Section: Introductionmentioning

confidence: 99%

Green fabrication route of robust, biodegradable silk sericin and poly(vinyl alcohol) nanofibrous scaffolds

Kumkun

Tuancharoensri

Ross

et al. 2019

Polymer International

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Silk sericin (SS) has been extensively used to fabricate scaffolds for tissue engineering. However, due to its inferior mechanical properties, it has been found to be a poor choice of material when being electrospun into nanofibrous scaffolds. Here, SS has been combined with poly(vinyl alcohol) (PVA) and electrospun to create scaffolds with enhanced physical properties. Crucially, these SS/PVA nanofibrous scaffolds were created using only distilled water as a solvent with no added crosslinker in an environmentally friendly process. Temperature has been shown to have a marked effect on the formation of the SS sol–gel transition and thus influence the final formation of fibers. Heating the spinning solutions to 70 °C delivered nanofibers with enhanced morphology, water stability and mechanical properties. This is due to the transition of SS from β‐sheets into random coils that enables enhanced molecular interactions between SS and PVA. The most applicable SS/PVA weight ratios for the formation of nanofibers with the desired properties were found to be 7.5/1.5 and 10.0/1.5. The fibers had diameters ranging from 60 to 500 nm, where higher PVA and SS concentrations promoted larger diameters. The crystallinity within the fibers could be controlled by manipulation of the balance between PVA and SS loadings. In vitro degradation (in phosphate buffer solution, pH 7.4 at 37 °C) was 30–50% within 42 days and fibers were shown to be nontoxic to skin fibroblast cells. This work demonstrates a new green route for incorporating SS into nanofibrous fabrics, with potential use in biomedical applications. © 2019 Society of Chemical Industry

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“…Here, PLA has been selected as the matrix material for fibrous membranes, due to its excellent miscibility with other polymers, biocompatibility and biodegradability. [37,38] Many blending systems based on PLA have been previously processed by electrospinning, including PLA:PEG, [39,40] PLA:PVP, [37] PLA:poly(vinyl alcohol), [41] PLA:poly(-caprolactone), [42,43] and so on. To achieve different payload release profiles from the core/shell fibers, mixtures of PLA:PVP and PLA:PEG were designed as the shell and core compositions, respectively.…”

Section: Fabrication and Characterization Of Core/shell Fibrous Membrmentioning

confidence: 99%

Superhydrophobic hierarchical fiber/bead composite membranes for efficient treatment of burns

Hui-yuan

et al. 2019

Acta Biomaterialia

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One of the current challenges in burn wound care is the development of multifunctional dressings that can protect the wound from bacteria or organisms and promote skin regeneration and tissue reconstitution. To this end, we report the design and fabrication of a composite electrospun membrane, comprised of electrospun polylactide: poly(vinyl pyrrolidone)/polylactide:poly(ethylene glycol) (PLA:PVP/PLA:PEG) core/shell fibers loaded with bioactive agents, as a functionally integrated wound dressing for efficient burns treatment. Different mass ratios of PLA:PVP in the shell were screened to optimize mechanical, physicochemical, and biological properties, in addition to controlled release profiles of loaded antimicrobial peptides (AMPs) from the fibers for desirable antibacterial activity. Fibroblasts were shown to readily adhere and proliferate when cultured on the membrane, indicating good in vitro cytocompatibility. The introduction of PLA beads by electrospraying on one side of the membrane resulted in biomimetic micro-nanostructures similar to those of lotus leaves. This designer structure rendered the composite membranes with superhydrophobic property to inhibit the adhesion/spreading of exogenous bacteria and other microbes. The administration of the resulting composite fibrous membrane on burnt skin in an infected rat model led to faster healing than a conventional product (sterile silicone membrane) and control detailed herein. These composite fibrous membranes loaded with bioactive drugs provide an integrated strategy for promoting burn wound healing and skin regeneration.

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Ternary blend nanofibres of poly(lactic acid), polycaprolactone and cellulose acetate butyrate for skin tissue scaffolds: influence of blend ratio and polycaprolactone molecular mass on miscibility, morphology, crystallinity and thermal properties

Cited by 29 publications

References 42 publications

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

Green fabrication route of robust, biodegradable silk sericin and poly(vinyl alcohol) nanofibrous scaffolds

Superhydrophobic hierarchical fiber/bead composite membranes for efficient treatment of burns

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