Terminalia catappa : Chemical composition, in vitro and in vivo effects on Haemonchus contortus

Katiki, Luciana Morita; Gomes, A. C. P.; Barbieri, Andiara Moraes Evangelista; Pacheco, Poliana Araújo; Rodrigues, L.; Verı́ssimo, Cecı́lia José; Gutmanis, Gunta; Piza, Ailton Marques; Louvandini, Hélder; Ferreira, Jorge

doi:10.1016/j.vetpar.2017.09.006

Cited by 23 publications

(15 citation statements)

References 37 publications

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“…Curiously, citronellal showed no anthelmintic activity in vivo, causing only a 0.7% epg reduction. Therefore, as occurred in other studies evaluating natural products derived from plants, in vitro anthelmintic efficacy was not reproduced in vivo (EGUALE et al, 2007;KATIKI et al, 2017).…”

Section: Discussionmentioning

confidence: 95%

Anthelmintic activity of Eucalyptus citriodora essential oil and its major component, citronellal, on sheep gastrointestinal nematodes

Araújo-Filho

Ribeiro

André

et al. 2019

Rev. Bras. Parasitol. Vet.

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This study aimed to evaluate the anthelmintic activity of Eucalyptus citriodora essential oil and citronellal on sheep gastrointestinal nematodes. Essential oil composition was determined by gas chromatography mass spectrometry. The substances were evaluated in vitro using adult worm motility test (AWMT) and transmission electron microscopy (TEM). The acute toxicity test in mice and the fecal egg count reduction test (FECRT) in sheep were performed. Citronellal was confirmed as the essential oil major constituent (63.9%). According to the AWMT, 2 mg/mL of essential oil and citronellal completely inhibited Haemonchus contortus motility at 6 h post exposure. H. contortus exposed to essential oil and citronellal exhibited internal ultrastructural modifications. The lethal dose 50 values in mice were 5,000 and 2,609 mg/kg for essential oil and citronellal, respectively. E. citriodora essential oil reduced sheep epg at 14 days post treatment by 69.5% (P<0.05). No significant differences were observed in epg between the citronellal and negative control groups (P>0.05). The interaction between citronellal and other constituents in the essential oil may be relevant for its in vivo anthelmintic activity. Thus, E. citriodora essential oil and citronellal pharmacokinetic studies may help elucidate the anthelmintic activity of these compounds.

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Section: Discussionmentioning

confidence: 95%

Anthelmintic activity of Eucalyptus citriodora essential oil and its major component, citronellal, on sheep gastrointestinal nematodes

Araújo-Filho

Ribeiro

André

et al. 2019

Rev. Bras. Parasitol. Vet.

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“…Also, T. catappa possess antiviral effect according to Chyau, Tsai, Ko, and Mau (2002). In addition, other compounds present in almond extract such as ursolic acid and 2α, 3β, 23-trihydroxyurs-12-en-28-oic acid show anti-inflammatory and hepatoprotective effects (Katiki et al, 2017;Xu, Xiao, Zhang, Zhou, & Liao, 2018). Nugroho et al (2017) suggested T. catappa extract increases total leucocytes, especially monocytes and granulocytes, and improves survival of B. splendens after bacterial challenge.…”

Section: Discussionmentioning

confidence: 97%

Terminalia catappa improves growth performance and survival of the Amazon leaf fish ( Monocirrhus polyacanthus ) larvae submitted to handling stress

et al. 2020

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The leaf fish Monocirrhus polyacanthus is an Amazon ornamental fish with a peculiar characteristic of mimicry of dead leaf form. Its mouth protrusion, slow-moving and transparent fins facilitate the capture of preys. Those are appreciated characteristics in the ornamental market, but its commercialization is based mainly on capture of wild fish (Catarino & Zuanon, 2010). Therefore, protocols for the breeding of this species in captivity are important to minimize the impact over the wild population as well as to provide a health fish to the world market. The larviculture of many ornamental fish species is an obstacle for their commercial production. Mortalities higher than 80% were reported in the early stages of life of M. polyacanthus kept in captivity (Ramos, Abe, & Fujimoto, 2016). Leaf fish larviculture also shows high mortality rate during transition to industrial feed due to cannibalism (Luz, Salaro, Souto, Okano, & Lima, 2002) and stressful rearing practices (Pederzoli & Mola, 2016). These stressors cause immunosuppression and consequently promote proliferation of pathogens causing disease outbreaks and economic lost (Behringer, Wood, Krkošek, & Bushek, 2020). These

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“…An alternative that has attained some attention is the inclusion of medicinal plants in the diet of animals. Several researchers have tested the plants used in folk medicine, evaluating their efficacy and safety through in vitro assays (FÉBOLI et al, 2016;MENGISTU et al, 2017;OLIVEIRA et al, 2017) at various stages of parasites' lives and in vivo with naturally infected and artificially infected sheep (KANOJIYA et al, 2015;KATIKI et al, 2017;BARONE et al, 2018). The anthelmintic properties of the plants are generally related to the presence of phytoconstituents such as tannins, flavonoids and saponins, which are present in larger amounts than other components.…”

Section: Introductionmentioning

confidence: 99%

In vitro ovicidal and larvicidal activity of Psidium cattleianum Sabine leaves against gastrointestinal nematodes of naturally infected sheep

Piza¹,

Féboli²,

Augusto³

et al. 2019

Bol. Ind. Anim.

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Gastrointestinal nematodes can affect sheep productivity via severe weight loss, anemia and death. Infection control is generally performed with synthetic anthelmintic compounds; however, indiscriminate use of these drugs can stimulate the emergence of resistant nematodes. Thus, alternatives to the use of synthetic anthelmintic compounds have been proposed, such as the inclusion of medicinal plants in animal feed. The objective of this study was evaluate the anthelmintic activity of the leaves of the medicinal plant Psidium cattleianum Sabine (Araçá) through its hydroalcoholic extract, and using in vitro assays with the eggs and larvae of gastrointestinal nematodes obtained from naturally infected donor sheep. The extract exhibited good in vitro ovicidal and larvicidal activity, with IC 50 values of 0.55 mg mL-1 for egg hatching inhibition, 0.20 mg mL-1 for larval development inhibition and an efficiency greater than 80% in the inhibition of larval migration at all concentrations evaluated (IC 50 < 0.19 mg/mL). Phytochemical analysis detected higher concentrations of saponins, flavonoids, cardiac glycosides, anthraquinones and tannins in the extract. Our results demonstrated that the Psidium cattleianum Sabine's leaves exhibit in vitro anthelmintic activity, which suggests that in addition to its other medicinal properties, this plant can help control gastrointestinal nematodes in sheep. Future in vivo assays should be performed to confirm antiparasitic efficacy.

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Terminalia catappa : Chemical composition, in vitro and in vivo effects on Haemonchus contortus

Cited by 23 publications

References 37 publications

Anthelmintic activity of Eucalyptus citriodora essential oil and its major component, citronellal, on sheep gastrointestinal nematodes

Anthelmintic activity of Eucalyptus citriodora essential oil and its major component, citronellal, on sheep gastrointestinal nematodes

Terminalia catappa improves growth performance and survival of the Amazon leaf fish ( Monocirrhus polyacanthus ) larvae submitted to handling stress

In vitro ovicidal and larvicidal activity of Psidium cattleianum Sabine leaves against gastrointestinal nematodes of naturally infected sheep

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