Terminal Myocardial Infarction

Abstract

In a prospective study of old, terminally ill patients who died from various conditions in a general hospital ward, the autopsy established a very high incidence of silent myocardial infarction. Acute myocardial infarction (AMI), clinically not suspected, was demonstrated at autopsy in 20 of 39 cases. 13 AMIs involved only the subendocardial layers. Severe coronary artery stenosis was three times as frequent among the AMI patients as among the others, but recent coronary artery thrombosis was observed in one case only. Clinical and laboratory observations failed to establish the diagnosis of AMI prior to death.

Profiling urinary metabolites of naproxen by liquid chromatography–electrospray mass spectrometry

“…A previously published LC-UV method from our group for the simultaneous determination of naproxen and naproxen glucuronide [17] was used as starting point to optimize the chromatographic conditions. The mobile phase used in that occasion, i.e.…”

“…Some analytical methods, based on liquid chromatography (LC), dealing with the determination of naproxen [13][14][15][16], naproxen and naproxen glucuronide [17], and naproxen, DMnaproxen and some conjugates [18] one LC-NMR study [19] has been reported dealing with the structural characterization of naproxen and DM-naproxen glucuronides. However, an expensive instrumentation was used and a tedious stop-flow chromatography was required.…”

Determination of naproxen in human urine by solid-phase microextraction coupled to liquid chromatography

“…Several methods dealing with naproxen determination have been reported [6][7][8][9][10][11][12], mainly based on liquid chromatography following traditional extraction procedures.…”