Term infants with hypoxic ischaemic encephalopathy: poor neurodevelopmental outcome despite standard neonatal intensive care

Toh,; Rajadurai, VS

doi:10.1093/tropej/45.4.229

Cited by 4 publications

(2 citation statements)

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“…Study name = country and median year of study. Citations: Australia (1989) (115), Australia (1995) (67), Australia (1996) (116), Canada (1993) (31), France (2000) (117,118), Ireland (2004) (118), Italy (1998) (119), Italy (2001) (120), Italy (2004) (58), Italy (2005) (121), Multi-country (2001) (122), Multi-country (2004) (105), Multi-country (2004) (107), Netherlands (1995) (123), Netherlands (1998) (124), Netherlands (2001) (125), New Zealand (1998) (126), New Zealand (1998) (127), Singapore (1994) (128), Sweden (1985) (59), Sweden (1988) (53), Switzerland (1981) (129), Switzerland (1994) (130), United Kingdom (1994) (51), United Kingdom (1997) (131), United Kingdom (2004) (106), United States (1997) (132), United States (1999) (133), United States (2002) (134). …”

Section: Figurementioning

confidence: 99%

Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990

et al. 2013

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Background:Intrapartum hypoxic events (“birth asphyxia”) may result in stillbirth, neonatal or postneonatal mortality, and impairment. Systematic morbidity estimates for the burden of impairment outcomes are currently limited. Neonatal encephalopathy (NE) following an intrapartum hypoxic event is a strong predictor of long-term impairment.Methods:Linear regression modeling was conducted on data identified through systematic reviews to estimate NE incidence and time trends for 184 countries. Meta-analyses were undertaken to estimate the risk of NE by sex of the newborn, neonatal case fatality rate, and impairment risk. A compartmental model estimated postneonatal survivors of NE, depending on access to care, and then the proportion of survivors with impairment. Separate modeling for the Global Burden of Disease 2010 (GBD2010) study estimated disability adjusted life years (DALYs), years of life with disability (YLDs), and years of life lost (YLLs) attributed to intrapartum-related events.Results:In 2010, 1.15 million babies (uncertainty range: 0.89–1.60 million; 8.5 cases per 1,000 live births) were estimated to have developed NE associated with intrapartum events, with 96% born in low- and middle-income countries, as compared with 1.60 million in 1990 (11.7 cases per 1,000 live births). An estimated 287,000 (181,000–440,000) neonates with NE died in 2010; 233,000 (163,000–342,000) survived with moderate or severe neurodevelopmental impairment; and 181,000 (82,000–319,000) had mild impairment. In GBD2010, intrapartum-related conditions comprised 50.2 million DALYs (2.4% of total) and 6.1 million YLDs.Conclusion:Intrapartum-related conditions are a large global burden, mostly due to high mortality in low-income countries. Universal coverage of obstetric care and neonatal resuscitation would prevent most of these deaths and disabilities. Rates of impairment are highest in middle-income countries where neonatal intensive care was more recently introduced, but quality may be poor. In settings without neonatal intensive care, the impairment rate is low due to high mortality, which is relevant for the scale-up of basic neonatal resuscitation.

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Section: Figurementioning

confidence: 99%

Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990

et al. 2013

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“…Com relação às variáveis do parto, não se encontrou nenhuma delas associada a evolução desfavorável do recém-nascido. Estas variáveis também se associam mais à asfixia e encefalopatia hipóxico-isquêmica do que ao prognóstico nos estudos (WAYENBERG et al, 1994;TORNBERG & EKSTRÖN, 1994;GONZÁLEZ de DIOS et al, 1997;TOH et al,1999;BOO et al 2000;CARLI et al, 2004). Estes autores descrevem como fatores de risco, em populações de recém-nascidos asfixiados a presença de sofrimento fetal agudo, rotura uterina, circular de cordão, prolapso de cordão, período expulsivo prolongado, parto cesárea, apresentação pélvica, porém nenhum deles associados ao prognóstico no seguimento dos recém-nascidos.…”

Section: 10-sensibilidade Especificidade Valor Preditivo Positivo Val...unclassified

Evolução neurologica de recem-nascidos com asfixia neonatal

Rosa¹,

Marba²

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Ao Prof. Dr. SÉRGIO TADEU MARTINS MARBA, pela amizade, confiança, apoio e orientação neste trabalho. À Profª Dra. MARIA VALERIANA L.DE MOURA RIBEIRO, pela amizade, entusiasmo e auxílio importante na revisão dos exames neurológicos e co-orientação do trabalho.À Dra MÔNICA APARECIDA PESSOTO, responsável pelo Ambulatório de Neonatologia, pelo empenho, que fez possível ter uma casuística consistente neste trabalho.

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A review of developmental outcomes of term infants with post-asphyxia neonatal encephalopathy

Eldridge

Galea

2009

European Journal of Paediatric Neurology

122

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Term infants with hypoxic ischaemic encephalopathy: poor neurodevelopmental outcome despite standard neonatal intensive care

Cited by 4 publications

References 0 publications

Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990

Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990

Evolução neurologica de recem-nascidos com asfixia neonatal

A review of developmental outcomes of term infants with post-asphyxia neonatal encephalopathy

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