“…The working hypothesis was that this would counteract the difficulties in reconstructive surgery caused by NBPs. Previous studies have investigated novel approaches for MRONJ treatment, including hyperbaric oxygen therapy (Freiberger et al, 2012), platelet-rich plasma (Adornato et al, 2007;Curi et al, 2011), low-intensity laser irradiation (Favia et al, 2018;Scoletta et al, 2010), parathyroid hormones (Cheung and Seeman, 2010;Sim et al, 2020), bone morphogenetic proteins (Park et al, 2017), plasma rich in growth factors (Mozzati et al, 2012), pentoxifylline and tocopherol (Heifetz- Li et al, 2019), and cell therapy (Tables 2 and 3). Of these, no treatment modality is widely accepted (De Souza Tolentino et al, 2019).…”