Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development

Harnett, Kristen G.; Moore, Lucy G.; Chin, Ashley; Cohen, Isabel C.; Lautrup, Rylee R.; Schuh, Sonya M.

doi:10.1016/j.crtox.2021.11.001

Cited by 21 publications

(12 citation statements)

References 114 publications

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“…Among the analogues, 39 tetramethyl bisphenol F (TMBPF) is reported to be the most recently produced. 40…”

Section: Bpa and Its Analogues As Potential Cause Of Endometriosismentioning

confidence: 99%

A review: Exposure to bisphenol a analogues in non-human primates as a potential cause of endometriosis

Apiyo,

Nyachieo,

Juma

et al. 2024

Journal of Endometriosis and Pelvic Pain Disorders

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Introduction: Bisphenol A is a synthetic compound widely used in the production of polycarbonate plastics and epoxy resins worldwide. As an environmental toxin, it has been reported in plastic equipment and utensils, water bottles and bottle tops, water supply pipes and epoxy resins that coat most of the metal food cans. It is a known endocrine-disrupting chemical and has been progressively replaced by its derivatives including bisphenol S, bisphenol F, bisphenol E, bisphenol AF, bisphenol B and tetramethyl bisphenol F. Bisphenol A and its analogues can bind to estrogen receptors and trigger multiple cellular responses at the organism level. Methods: A comprehensive literature review was done utilising electronic databases of PubMed, Google Scholar, Hinari, Connected papers and Science Direct from 1991 onwards. The articles were only included if they reported original relevant research and were limited to articles written in English. Results: Animal models, including non-human primates, have been used to study their effects on the endocrine system. Its endocrine disruption activity is reported to be the most studied effect in reproductive biology indicating that it may potentially cause endometriosis in females. Though non-human primates are closely related to humans, limited data exists on their associations between Bisphenol A exposure and its analogues and the pathophysiology of endometriosis. Conclusion: Given the current multifaceted knowledge/theory on endometriosis etiology, there is a strong necessity to conduct further biomedical research that utilises non-human primates to study the link between endocrine-disrupting chemicals and its effects on endometriosis.

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“…Among the analogues, 39 tetramethyl bisphenol F (TMBPF) is reported to be the most recently produced. 40…”

Section: Bpa and Its Analogues As Potential Cause Of Endometriosismentioning

confidence: 99%

A review: Exposure to bisphenol a analogues in non-human primates as a potential cause of endometriosis

Apiyo,

Nyachieo,

Juma

et al. 2024

Journal of Endometriosis and Pelvic Pain Disorders

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“…Due to these adverse effects, BPA analogs have been introduced to the market, generating products called "BPA-free", such as bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF) [17,55]. However, most of these compounds exhibit variable estrogenic activity, although generally of lower biological potency than BPA [44,61].…”

Section: Gper-1 a New Approach To The Understanding Of Breast Cancer ...mentioning

confidence: 99%

Bisphenols and Their Interaction with GPER-1: The Invisible Enemy Behind Breast Cancer and Its Societal Impact

Molina,

D. Figueroa,

Ehrenfeld

2024

Bisphenols - New Environmental, Pathophysiological and Social Perspectives [Working Title]

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Bisphenols are chemical compounds of industrial origin found in a wide variety of everyday consumer products and have been detected in virtually all human biological fluids. Bisphenols, especially bisphenol A (BPA), can mimic hormone activity and act as endocrine disruptors through GPER-1, a G protein-coupled receptor, mainly located in the cell membrane and with a high affinity for estradiol, whose activity commands neoplastic cell proliferation and migration, promoting the development of breast cancer. Since in modern societies bisphenols are very common in the environment, their association with breast cancer affects not only individuals but also the general population. The detrimental impacts of these substances on public health, however, have not received enough attention because their molecular and cellular effects are imperceptible, and their manifestations only become apparent over the medium and long term.

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“…There is a long tradition of using avian embryos to study sexual development and potential effects of environmental pollutants including EDCs ( Berg et al, 1998 ; Berge et al, 2004 ; Biau et al, 2007 ; Eising et al, 2001 ; Estermann, Major & Smith, 2021 ; Fry & Toone, 1981 ; Ioannidis et al, 2021 ). It is well known that the exposure of xenobiotics during avian embryonic development can induce irreversible deformities or malformations of the sex organs and disrupt sex-specific behavior ( Farhat et al, 2020 ; Guioli et al, 2020 ; Harnett et al, 2021 ; Mentor et al, 2020a ; Mentor et al, 2020b ; Ottinger et al, 2008 ; Quinn, Summitt & Ottinger, 2008 ; Sharin et al, 2021 ). One advantage is that the avian egg can be considered as a closed system lacking any exchange with its environment except for the interchange of gases.…”

Section: Introductionmentioning

confidence: 99%

No effects of the antiandrogens cyproterone acetate (CPA), flutamide and p,p’-DDE on early sexual differentiation but CPA-induced retardation of embryonic development in the domestic fowl (Gallus gallus domesticus)

Jessl,

Oehlmann

2023

PeerJ

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Because a wide range of environmental contaminants are known to cause endocrine disorders in humans and animals, in vivo tests are needed to identify such endocrine disrupting chemicals (EDCs) and to assess their biological effects. Despite the lack of a standardized guideline, the avian embryo has been shown to be a promising model system which responds sensitively to EDCs. After previous studies on the effects of estrogenic, antiestrogenic and androgenic substances, the present work focuses on the effects of in ovo exposure to p,p’-DDE, flutamide and cyproterone acetate (CPA) as antiandrogenic model compounds regarding gonadal sex differentiation and embryonic development of the domestic fowl (Gallus gallus domesticus). The substances were injected into the yolk of fertilized eggs on embryonic day one. On embryonic day 19 sex genotype and phenotype were determined, followed by gross morphological and histological examination of the gonads. Treatment with flutamide (0.5, 5, 50 µg/g egg), p,p’-DDE (0.5, 5, 50 µg/g egg) or CPA (0.2, 2, 20 µg/g egg) did not affect male or female gonad development, assessed by gonad surface area and cortex thickness in both sexes and by the percentage of seminiferous tubules in males as endpoints. This leads to the conclusion that antiandrogens do not affect sexual differentiation during embryonic development of G. gallus domesticus, reflecting that gonads are not target organs for androgens in birds. In ovo exposure to 2 and 20 µg CPA/g egg, however, resulted in significantly smaller embryos as displayed by shortened lengths of skull, ulna and tarsometatarsus. Although gonadal endpoints were not affected by antiandrogens, the embryo of G. gallus domesticus is shown to be a suitable test system for the identification of substance-related mortality and developmental delays.

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Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development

Abstract: Graphical abstract

Cited by 21 publications

References 114 publications

A review: Exposure to bisphenol a analogues in non-human primates as a potential cause of endometriosis

A review: Exposure to bisphenol a analogues in non-human primates as a potential cause of endometriosis

Bisphenols and Their Interaction with GPER-1: The Invisible Enemy Behind Breast Cancer and Its Societal Impact

No effects of the antiandrogens cyproterone acetate (CPA), flutamide and p,p’-DDE on early sexual differentiation but CPA-induced retardation of embryonic development in the domestic fowl (Gallus gallus domesticus)

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