Bisphenols and Their Interaction with GPER-1: The Invisible Enemy Behind Breast Cancer and Its Societal Impact
Luis Molina,
Carlos D. Figueroa,
Pamela Ehrenfeld
Abstract:Bisphenols are chemical compounds of industrial origin found in a wide variety of everyday consumer products and have been detected in virtually all human biological fluids. Bisphenols, especially bisphenol A (BPA), can mimic hormone activity and act as endocrine disruptors through GPER-1, a G protein-coupled receptor, mainly located in the cell membrane and with a high affinity for estradiol, whose activity commands neoplastic cell proliferation and migration, promoting the development of breast cancer. Since… Show more
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