Teratogenic Effect of Meloxicam on Pregnant Rats: Implication of Organogenesis Period

Abstract

This study was carried out to detect the risk of meloxicam use on fetuses. It was given to pregnant rats orally by dose1.35 and 2.70 mg/kg b.wt, from 6 th day until the 15 th day of gestation daily. At 20 th day of gestation female sacrified; morphological, visceral, skeletal, biochemical and histopathological studies were carried out to evaluate its harmful effect. Meloxicam increased abortion rate and fetal resorptions as well as growth retardation and external malformations as hematoma and paralysis of limbs. Visceral examination showed defects in internal organs. Weak and incomplete ossification in axial and appendicular system were observed by skeletal examination. Drug caused increased level of MDA meanwhile reduction of glutathione reduced in liver tissue of fetuses. The histopathological examination revealed presence of marked degenerative changes in liver and kidney of fetuses. This study support and proof the potential risks of the Meloxicam administration on fetuses.

Adverse effects of moxifloxacin and flunixin meglumine and their combination on pregnant rats

“…In addition. [3] mentioned that, piroxicam evoked some cellular inflammations, shrunken glomeruli, edema and vacuolation in the tubular cells of the kidney [3].stated that, meloxicam revealed swelling in the endothelial cells lining the tufts associated with degeneration and necrosis in the tubular lining epithelium of the glomeruli of kidney.…”

“…Such drugs may cause some adverse effects on pregnant females and can induce teratogenic effect [2]. Some drugs can cross the placental barrier and enter fetal circulation during pregnancy, so they may produce some sort of fetal abnormalities [3]. Fluoroquinolones are group of antibacterial agents which affect G +Ve and G -Ve bacteria.…”