1968
DOI: 10.1097/00132586-196810000-00021
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Teratogenic Activity of Nitrous Oxide

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Cited by 13 publications
(13 citation statements)
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“…34,35 The mechanism by which N 2 O induces vitamin B 12 deficiency is through the oxidation of cobalamin I to cobalamin III. 37,38 Mazze and Kallen 39 found that administration of 75% N 2 O to pregnant rats for 24 hours on day 9 of gestation increased the incidence of fetal malformations and both early and late resorptions. 36 Studies are conflicting in regard to fetal outcome after exposure to N 2 O.…”
Section: Nitrous Oxidementioning
confidence: 99%
“…34,35 The mechanism by which N 2 O induces vitamin B 12 deficiency is through the oxidation of cobalamin I to cobalamin III. 37,38 Mazze and Kallen 39 found that administration of 75% N 2 O to pregnant rats for 24 hours on day 9 of gestation increased the incidence of fetal malformations and both early and late resorptions. 36 Studies are conflicting in regard to fetal outcome after exposure to N 2 O.…”
Section: Nitrous Oxidementioning
confidence: 99%
“…Concerns about teratogenicity arose with animal studies showing resorption of foetuses, low‐birth weight, and skeletal anomalies associated with exposures to nitrous oxide and halothane [Fink et al, 1967; Basford and Fink, 1968; Bussard, 1976]. Since then, a series of epidemiological studies have reported increased risks of spontaneous abortion [American Society of Anesthesiologists, 1974; Axelsson and Rylander, 1982; Johnson et al, 1987; McDonald et al, 1988a; Guirguis et al, 1990; Saurel‐Cubizolles et al, 1994; Rowland et al, 1995; Gauger et al, 2003], though some have not [Lauwerys et al, 1981; Ericson and Kallen, 1985; Hemminki et al, 1985; Shuhaiber et al, 2002].…”
Section: Introductionmentioning
confidence: 99%
“…45 A review of the published data indicates that properly administered N 2 O with a scavenger system does not increase the incidence of spontaneous abortions, infertility or teratogenicity in exposed pregnant women. 46 N 2 O should not be given to patients after head injury or to anybody with an impaired mental state.…”
Section: Safetymentioning
confidence: 99%