Teratocarcinosarcoma of the paranasal sinuses: A clinicopathologic and immunohistochemical study

Pai, Sanjay A; Naresh, Kikkeri N.; Masih, Kanwal; Ramarao, Clementina; Borges, Anita M.

doi:10.1016/s0046-8177(98)90281-7

Cited by 80 publications

(81 citation statements)

References 11 publications

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“…[4][5][6] Immunohistochemical studies clearly demonstrated SNTCS usually occur in elderly males with an average age at presentation of 51.75 years. 4,7 It rarely occurs at a younger age.…”

Section: Case Reportmentioning

confidence: 99%

“…[4][5][6] Immunohistochemical studies clearly demonstrated SNTCS usually occur in elderly males with an average age at presentation of 51.75 years. 4,7 It rarely occurs at a younger age. Only 4 cases below the age of 25 years reported till date, all of them coming from Indian subcontinent; a fact possibly pointing towards a common environmental or genetic link predisposing to early onset of this tumour.…”

Section: Case Reportmentioning

confidence: 99%

“…Publications advocating neoadjuvant chemotherapy to downstage the tumour and promote maturation of the neuroectodermal component in SNTCS and use of histology specific chemotherapy for a better outcome are indicative of attempts to progress in similar direction. 4,9 Disease free status of index case for last 3 years in follow-up prepared us to propose a minimally invasive less deforming endoscope-assisted resection followed by customised 'Histology-directed Chemotherapy' along with radiation as a better alternative to aggressive radical excision for managing SNTCS.…”

Section: Case Reportmentioning

confidence: 99%

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Sinonasal teratocarcinosarcoma: is minimally invasive resection followed by adjuvant histology directed chemo-radiation a better alternative to radical excision? Case report

Singh¹,

Sen²,

Sharma³

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Sinonasal teratocarcinosarcoma (SNTCS) is a rare higly malignant tumour occuring almost exclusively in the sinonasal tract. This aggressive tumour arising from the primitive embryonic or immature pluripotential cells of olfactory epithelium has high propencity for loco-regional recurrence and mortality. SNTCS generally presents with relatively benign symptoms like nasal obstruction and recurrent epistaxis in its early stage. In advance stage with orbital and intracranial spread other symptoms raising suspicion of malignancy, such as dysphagia, odynophagia, epiphora, vision loss, exophthalmos, anosmia, headache and altered sensorium appears. In view of its aggressive behaviour, radical excision with or without chemoradiation is advocated as the optimum treatment. Local recurrence of SNTCS after excision has been reported as high as 45% with a mean recurrence time of 21.3 months. Even though distant metastasis is rare, local recurrence frequently leads to treatment failure and subsequent death. Here we share our experience of SNTCS in a 23 year old male managed with endoscopic craniofacial resection followed by histocytology directed chemotherapy with external beam radiation. He remains disease free in last 3 years of follow up.

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“…[4][5][6] Immunohistochemical studies clearly demonstrated SNTCS usually occur in elderly males with an average age at presentation of 51.75 years. 4,7 It rarely occurs at a younger age.…”

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

See 1 more Smart Citation

Sinonasal teratocarcinosarcoma: is minimally invasive resection followed by adjuvant histology directed chemo-radiation a better alternative to radical excision? Case report

Singh¹,

Sen²,

Sharma³

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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“…The salivary glands are the most common location of carcinosarcoma within the head and neck region [6]. The incidence of carcinosarcoma within the nasal cavity and paranasal sinuses is extremely rare and previous studies have consequently been limited to small case series and a recent systematic review [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Cesium-131 Brachytherapy Seeds for the Treatment of Sinonasal Carcinosarcoma: A Case Report and Literature Review

Kutler¹

2017

OHNS

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A 70-year old male with poor cognitive function presented to an outside hospital in November 2010 with recurrent left-sided epistaxis. This patient had a history significant for anaplastic oligoastrocytoma Patel KR, et al., J Otolaryng Head Neck Surg 2017, 3: Radiation-induced tumors of the skull base pose a significant treatment challenge. Temporary Brachytherapy (BRT) with Cesium-131(Cs-131) seeds is a novel therapeutic technique that holds significant potential for the achievement of local tumor control in patients with limited therapeutic options. MethodsWe report a 70 year-old patient with a history of anaplastic oligoastrocytoma who presented with recurrent left-sided epistaxis. Imaging and biopsy results revealed a high-grade carcinosarcoma of the paranasal sinuses and skull base. The Sinonasal Carcinosarcoma (SN-CS) was resected and the residual micro tumor was treated with Cs-131 BRT seeds attached to a vicryl mesh, which was removed 6 weeks later. ResultsFollow-up examination demonstrated no evidence of recurrence or metastasis for 9 months and the patient had an overall survival of 15 months after treatment with Cs-131 BRT. ConclusionTemporary BRT with Cs-131 seeds may play a pivotal role in achieving local tumor control and palliation in patients with aggressive skull base tumors who are precluded from receiving more extensive forms of radiotherapy.

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“…[1][2][3] As the tumor contains various components of teratoma, sarcoma and carcinoma arising from cells of embryonal origin majority of the patients suffer locoregional failure. 4,5 Heffner and Hyams coined the term 'teratocarcinosarcoma' based on a clinicopathological study of 20 patients with sinonasal tract neoplasms. 4 The majority of reports have focused on pathology and immunohistochemistry and earlier these tumors were reported as teratoid carcinosarcoma, blastoma and malignant teratoma.…”

Section: Introductionmentioning

confidence: 99%

Sinonasal Teratocarcinosarcoma: A Rare Clinical Entity managed by Medial Maxillectomy and Adjuvant Chemoradiation

Gupta¹,

Naik²,

Lnu³

et al. 2012

An International Journal Clinical Rhinology

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Teratocarcinosarcoma of the paranasal sinuses: A clinicopathologic and immunohistochemical study

Cited by 80 publications

References 11 publications

Sinonasal teratocarcinosarcoma: is minimally invasive resection followed by adjuvant histology directed chemo-radiation a better alternative to radical excision? Case report

Sinonasal teratocarcinosarcoma: is minimally invasive resection followed by adjuvant histology directed chemo-radiation a better alternative to radical excision? Case report

Cesium-131 Brachytherapy Seeds for the Treatment of Sinonasal Carcinosarcoma: A Case Report and Literature Review

Sinonasal Teratocarcinosarcoma: A Rare Clinical Entity managed by Medial Maxillectomy and Adjuvant Chemoradiation

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