Teratocarcinosarcoma of the nasal cavity and ethmoid

Abstract

Sinonasal teratocarcinosarcoma is very unusual malignant neoplasm histologically consisting of an epithelial element and one or more mesenchymal components. This is a report of teratocarcinosarcoma, in a 74-year-old male, involving the right nasal cavity and ethmoids with intracranial extension. The tumour was totally resected via the craniofacial approach and the patient was given post-operative chemotherapy. Extensive tumour necrosis, rapid growth and local destruction are the prominent features of this tumour. The clinical presentation, pathological features and clinical course of this rare malignancy are discussed with a review of the literature.

Sinonasal teratocarcinosarcoma: is minimally invasive resection followed by adjuvant histology directed chemo-radiation a better alternative to radical excision? Case report

“…Even though distant metastasis is rare, local recurrence frequently leads to treatment failure and subsequent death. 6,8 In contrary to this general consensus, our patient received a more conservative 'Endoscope assisted Craniofacial Resection ensurring no residual visible tumour. R esection was followed with 6 cycles of Cisplatin (20 mg/m 2 day) and Etoposide (100 mg/m 2 day) directed by the prominence of premature neuroectodermal and epithelial elements embeded in sarcomatous stroma, followed by 70 Gy of external beam radiation.…”

Sinonasal Teratocarcinosarcoma: A Rare Clinical Entity managed by Medial Maxillectomy and Adjuvant Chemoradiation

“…3 Most of the literature reported a 89% incidence in males and 11% in females. [2][3][4][5][6][7][8][9][10][11][12][13][14][15] The rapid growth and extensive local destruction hinders early diagnosis. Diagnosis is made by the presence of immature neural tissue and fetal epithelial structure admixed with various malignant and mesenchymal elements.…”

“…14,20,24 Local recurrence after surgery was seen in 30 to 43%, hence, adjuvant treatment is recommended in the form of radiation and chemotherapy. 6,7 As the tumor is highly aggressive and rare no adequate radiotherapy doses are described and individualization of therapy should be considered. 13,14 The complex tumor shape and close proximity to critical structures has made 3D CRT and IMRT better in delivering higher radiation doses to the target volumes.…”

“…4 The majority of reports have focused on pathology and immunohistochemistry and earlier these tumors were reported as teratoid carcinosarcoma, blastoma and malignant teratoma. [5][6][7][8] The rare presentation of the tumor and varied combination of histopathological…”

Teratocarcinosarcoma rinosinusal: Reporte de un caso

“…Se compone de epitelio benigno o maligno, mesénquima (cartílago, hueso o músculo liso) y elementos neurales 2 . También ha sido llamado teratoma maligno [3][4][5] carcinoma teratoide 6,7 , blastoma 8 y teratocarcinosarcoma maligno 9 . Los hallazgos clínicos más característicos son un tumor en la cavidad nasal, que compromete el seno maxilar ipsilateral o el seno etmoidal.…”