Terahertz molecular resonance of cancer DNA

Cheon, Hwayeong; Yang, Hee-Jong; Lee, Sang-Hun; Kim, Young A; Son, Joo‐Hiuk

doi:10.1038/srep37103

Cited by 144 publications

(69 citation statements)

References 55 publications

(59 reference statements)

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“…A recent study involving methylated DNA, an aberrant DNA type found in early stage cancers, found it has a distinctive molecular resonance at 1.67 THz. By quantifying the THz spectral amplitudes at 1.67 THz, the degree of DNA methylation is ascertained and these results matched the gold-standard commercial enzyme-linked immunosorbent assay (ELISA) like reaction method well, and noting greater precision when using THz (11).…”

Section: Review Articlementioning

confidence: 99%

Recent advances in terahertz technology for biomedical applications

Sun¹,

He²,

Li³

et al. 2017

Quant. Imaging Med. Surg.

219

113

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Terahertz instrumentation has improved significantly in recent years such that THz imaging systems have become more affordable and easier to use. THz systems can now be operated by non-THz experts greatly facilitating research into many potential applications. Due to the non-ionising nature of THz light and its high sensitivity to soft tissues, there is an increasing interest in biomedical applications including both in vivo and ex vivo studies. Additionally, research continues into understanding the origin of contrast and how to interpret terahertz biomedical images. This short review highlights some of the recent work in these areas and suggests some future research directions.

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Section: Review Articlementioning

confidence: 99%

Recent advances in terahertz technology for biomedical applications

Sun¹,

He²,

Li³

et al. 2017

Quant. Imaging Med. Surg.

219

113

View full text Add to dashboard Cite

show abstract

“…Some of the features, such as non-ionizing, non-invasive, high penetration, high resolution and spectral fingerprinting [2,3], make THz wave a potential tool in biomedical field. Based on THz spectroscopy, many groups succeeded to obtain the fingerprint spectra of medicines [4][5][6][7][8], biomarkers [9][10][11][12][13], deoxyribonucleic acid (DNA) [14][15][16][17] and images of different cancers [18][19][20][21][22][23][24][25]. However, merely little work further studied the identification of biomarkers in actual biological samples, such as tissue, blood and urine.…”

Section: Introductionmentioning

confidence: 99%

Terahertz spectroscopy in biomedical field: a review on signal-to-noise ratio improvement

et al. 2020

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With the non-ionizing, non-invasive, high penetration, high resolution and spectral fingerprinting features of terahertz (THz) wave, THz spectroscopy has great potential for the qualitative and quantitative identification of key substances in biomedical field, such as the early diagnosis of cancer, the accurate boundary determination of pathological tissue and non-destructive detection of superficial tissue. However, biological samples usually contain various of substances (such as water, proteins, fat and fiber), resulting in the signal-to-noise ratio (SNR) for the absorption peaks of target substances are very small and then the target substances are hard to be identified. Here, we present recent works for the SNR improvement of THz signal. These works include the usage of attenuated total reflection (ATR) spectroscopy, the fabrication of sample-sensitive metamaterials, the utilization of different agents (including contrast agents, optical clearing agents and aptamers), the application of reconstruction algorithms and the optimization of THz spectroscopy system. These methods have been proven to be effective theoretically, but only few of them have been applied into actual usage. We also analyze the reasons and summarize the advantages and disadvantages of each method. At last, we present the prospective application of THz spectroscopy in biomedical field.

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“…[40] Although a substantial effort has been made to understand the toxic mechanism behind the interaction between membranes and Ab oligomers, it still remains elusive because Ab oligomer toxicity can be induced by size-dependent, composed residues, polymorphic structures, and diverse conformations of aggregates. [41][42][43][44] Therefore, characterizing the molecular architecture of Ab oligomers and formation pathways is critical to develop strategies for preventing, controlling, and regulating amyloid formation. In aqueous solutions or membranes, Ab oligomers possess polymorphic structural characteristics depending on various environmental conditions, such as ionic concentrations, pH, and thermal fluctuations.…”

Section: Introductionmentioning

confidence: 99%

Length‐Dependent Manifestation of Vibration Modes Regulates a Specific Intermediate Morphology of Aβ17‐42 in Different Environments

Choi

Yoon

2018

ChemPhysChem

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Various cytotoxic mechanisms for neurodegenerative disease are induced by specific conformations of Aβ intermediates. The efforts to understand the diverse intermediate forms of amyloid oligomers have been focused on understanding the aggregation mechanism of specific morphologies for Aβ intermediates. However, these are still not easy tasks to be accomplished because the diverse conformations of Aβ intermediates can be altered during the aggregation process, even though the same Aβ monomers are present. Thus, efforts to reveal the conformational change mechanism could be a fundamental process to understand the formation of diverse Aβ intermediate conformations. Here, we evaluate the conformational characteristics of Aβ fibrillar oligomers in different environments according to the length. We observed that Aβ fibrillar oligomers optimize their inherent hydrogen bonds and configurational entropy to stabilize their structure according to the simulation time and their length increase. In addition, we revealed the role of the expressed vibration mode shape in the fibrillar oligomers' elongation and deformation processes. Our results suggest that limitations in amyloid oligomer growth and transformations of their morphologies can be regulated and controlled by modifying the vibration features.

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Terahertz molecular resonance of cancer DNA

Cited by 144 publications

References 55 publications

Recent advances in terahertz technology for biomedical applications

Recent advances in terahertz technology for biomedical applications

Terahertz spectroscopy in biomedical field: a review on signal-to-noise ratio improvement

Length‐Dependent Manifestation of Vibration Modes Regulates a Specific Intermediate Morphology of Aβ17‐42 in Different Environments

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