Tenascins in fibrotic disorders—from bench to bedside

Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization

“…These large oligomeric proteins are homologous in structure and are made as homotrimers or hexamers that contain tandem epidermal growth factor and fibronectin type III repeats and a fibrinogen homology domain (119, 120). As a family, the tenascins have been shown to play roles in cancer, fibrosis, and the function of the central nervous system (CNS) (120, 121). However, more specialized roles in physiological and pathological conditions have been described for each member.…”

Expression of tenascin‐C in a rat vocal fold injury model and its regulation of fibroblasts

“…Tnc is primarily expressed during embryonic development, with distinct spatial and temporal patterns. In adults, Tnc expression is detected in inflammatory and fibrotic diseases in various organs and systems, including the kidney, lung, liver, cardiovascular system, intestine, and skin . Its tightly regulated expression pattern makes Tnc an attractive candidate biomarker and therapy target …”

“…In adults, Tnc expression is detected in inflammatory and fibrotic diseases in various organs and systems, including the kidney, lung, liver, cardiovascular system, intestine, and skin. [4][5][6][7] Its tightly regulated expression pattern makes Tnc an attractive candidate biomarker and therapy target. 6 In this study, we investigated Tnc expression in a rat vocal fold injury model in vivo and its roles in regulating the fibroblast phenotype in vitro.…”

Matricellular Proteins and Organ Fibrosis

“…While several past studies showed the up-regulation of TN-C and examined its role in fibrotic diseases of various organs (75), recent research has been mostly focused on the identification of TN-C as biomarker for disease progression. In cardiac disease, re-expression of the fetal splicing variant B+ TN-C in the heart or serum was correlated with signs of rejection of transplanted subjects or decreased survival and increased risk to undergo transplantation in a group of dilated cardiomyopathy patients (77,78).…”

“…Tenascins are a family of large oligomeric ECM glycoproteins consisting of four members, tenascin C, X, R and W, with similar characteristics but differing expression patterns (75,76).…”