Expression of tenascin‐C in a rat vocal fold injury model and its regulation of fibroblasts

Li, Juan; Liu, Y.; Wang, Yiming; Xu, Wen

doi:10.1002/lary.27164

Cited by 7 publications

(2 citation statements)

References 19 publications

(48 reference statements)

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“…With gradual change of wound microenvironment, it was more conducive to take shape of granulation tissue. They were related to wound contraction and collagen production, and they acted a vital role in wound healing ( Werne et al, 2007 ; Watt and Fujiwara, 2011 ; Li et al, 2018 ). In Figure 2A , we had proved that our synthesized ZnO-Ber/H had no cytotoxicity and the cells could survive normally without causing cell death through a live-dead staining kit.…”

Section: Resultsmentioning

confidence: 99%

Encapsulation of berberine decorated ZnO nano-colloids into injectable hydrogel using for diabetic wound healing

Yin

Fan

Zhou³

et al. 2022

Front. Chem.

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Chronic wound healing in diabetic patients had been considered a major clinical challenge, so there was an urgent need to establish more effective treatment methods. In this study, we prepared berberine-modified ZnO nano-colloids hydrogel (ZnO-Ber/H) and evaluated its wound healing performance in a diabetic rat. The prepared ZnO-Ber/H had excellent moisturizing, anti-inflammatory and anti-oxidative stress abilities. In vitro, ZnO-Ber/H could effectively up-regulate antioxidant stress factors (Nrf2, HO-1, NQO1) by 4.65-fold, 2.49-fold, 2.56-fold, respectively. In vivo experiments have shown that ZnO-Ber/H could effectively improve the wound healing rate (92.9%) after 15 days of treatment. Meanwhile, the ability of anti-oxidative stress had also been verified in vivo. ZnO-Ber/H down-regulated inflammatory factor (TNF-α, IL-1β, and IL-6) by 72.8%, 55% and 71% respectively, up-regulated vascular related factors VEGF and CD31 by 3.9-fold and 3.2-fold by Western blot. At the same time, ZnO-Ber/H could promote the expression of EGFR and FGFR, thereby affecting the generation of new epithelial tissue. Based on extensive characterization and biological evaluation, ZnO-Ber/H was expected to be a potential candidate for promoting diabetic wound healing.

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Section: Resultsmentioning

confidence: 99%

Encapsulation of berberine decorated ZnO nano-colloids into injectable hydrogel using for diabetic wound healing

Yin

Fan

Zhou³

et al. 2022

Front. Chem.

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“…The remaining five proteins were involved in the development of a variety of tissues, some more relevant than others. Firstly, Tenascin C was involved in wound healing, during which it stimulates fibroblasts to increase the ECM protein synthesis 44 , thereby making it an attractive target for regenerative treatment. Interestingly, Thrombospondin 3 has proven to be important for osteogenesis, but its development functions in the NP remain unknown 45 .…”

Section: Ecm Assembly Pathwaysmentioning

confidence: 99%

Part 1: profiling extra cellular matrix core proteome of human fetal nucleus pulposus in search for regenerative targets

Rajasekaran

Tangavel

Djuric

et al. 2020

Sci Rep

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Intervertebral disc degeneration is accompanied by a loss of Extra-cellular matrix (ECM) due to an imbalance in anabolic and catabolic pathways. Identifying ECM proteins with anabolic and/or regenerative potential could be the key to developing regenerative therapies. Since human fetal discs grow and develop rapidly, studying these discs may provide valuable insights on proteins with regenerative potential. This study compares core matrisome of 9 fetal and 7 healthy adult (age 22–79) nucleus pulposus (NP), using a proteomic and bioinformatic approach. Of the 33 upregulated proteins in fetus NP’s, 20 of which were involved in ECM assembly pathways: fibromodulin, biglycan, heparan sulfate proteoglycan 2, chondroitin sulfate proteoglycan 4, procollagen C-endopeptidase enhancer and Collagen—type 1a1, 1a2, 6a1, 6a3, 11a1, 11a2, 12a1, 14a1 and 15a1. Moreover, 10 of the upregulated proteins were involved in growth pathways ‘PI3L-Akt signaling’ and ‘regulation of insulin like growth factor transport and uptake.’ Thrombospondin 1,3 and 4, tenascin C, matrilin-3, and collagen- type 1a1, 1a2, 6a1, 6a3 and 9a1. Additionally, matrillin-2 and ‘Collagen triple helix repeat containing 1’ were identified as possible regenerative proteins due to their involvement in ‘Regeneration’ and ‘tissue development’ respectively. In conclusion, the consistency of human fetal NP’s differs greatly from that of healthy adults. In view of these outcomes, the core matrisome of human fetal discs contains an abundant number of proteins that could potentially show regenerative properties, and their potential should be explored in future machinal experiments.

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SOCS3 Silencing Promotes Activation of Vocal Fold Fibroblasts via JAK2/STAT3 Signaling Pathway

Wang

et al. 2023

Inflammation

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Expression of tenascin‐C in a rat vocal fold injury model and its regulation of fibroblasts

Abstract: NA Laryngoscope, 128:E316-E322, 2018.

Cited by 7 publications

References 19 publications

Encapsulation of berberine decorated ZnO nano-colloids into injectable hydrogel using for diabetic wound healing

Encapsulation of berberine decorated ZnO nano-colloids into injectable hydrogel using for diabetic wound healing

Part 1: profiling extra cellular matrix core proteome of human fetal nucleus pulposus in search for regenerative targets

SOCS3 Silencing Promotes Activation of Vocal Fold Fibroblasts via JAK2/STAT3 Signaling Pathway

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