Ten years of clinical experience with cyanoacrylate glue for venous access in a 1300-bed university hospital

Abstract

In the past decade, cyanoacrylate glue has been progressively introduced into the clinical practice of venous access devices used for different purposes. Glue has been used to increase device stabilisation (to reduce the risk of catheter dislodgement), to seal the exit site (to both reduce local bleeding and decrease the risk of bacterial contamination) and to close skin incisions required for the insertion of tunnelled catheters or totally implanted venous ports. For many of these purposes, the efficacy and cost-effectiveness of cyanoacrylate glue has been demonstrated, while some indications are still controversial. This article reports on 10 years of clinical experience with cyanoacrylate glue in a large university hospital, and provides a narrative review of the scientific evidence on the benefits of glue in venous access that has been accumulating over the past decade.

Effectiveness of cyanoacrylate glue in the fixation of midline catheters and peripherally inserted central catheters in hospitalised adult patients: Randomised clinical trial (CIANO-ETI)

“…Consequently, as concluded in the study by Pittiruti et al, 2 it appears that CAG may reduce the risk of infection by reducing bacterial contamination via the extraluminal route in all VADs.…”

“…Recently, in clinical practice there has been growing interest in products for the safe securement of vascular access devices (VADs) to try to decrease their associated complications. One such product is cyanoacrylate glue (CAG), 1 – 3 with octyl-butyl-cyanoacrylate (e.g. Secure-Port IV™) being one of the most commonly used types today.…”

Peripherally inserted central catheter securement with cyanoacrylate glue and bloodstream infection: A retrospective cohort study

“…Previous studies have shown that the use of CG was effective in reducing bleeding at the puncture site and controlling infection rather than immobilizing the catheter. [14][15][16] Our study using chest radiographs showed that the use of CG also inhibited catheter tip migration within the body. Because arrhythmias were not monitored, their incidence rate could not be evaluated.…”

“…13 However, although previous studies have shown that the use of CG is effective in controlling bleeding from the catheter insertion site and reducing infection, reports from Asia or Japan are lacking. 14,15 In addition, the effect of CG on catheter fixation has only been evaluated in studies using catheter length outside the body, and there have been no studies evaluating catheter tip position inside the body, which is supposed to affect the occurrence of complications. 16 In this study, we aimed to investigate the effect of CG on the suppression of catheter-related complications, such as catheter infection and thrombus formation, at the first institution in Japan to adopt CG for peripherally inserted central catheter (PICC) fixation in acutely ill adult patients.…”

“…The 2021 Infusion Nurses Society infusion therapy standards of practice 12 and the National Institute for Health and Care Excellence recommend the use of CGs to prevent catheter‐related complications 13 . However, although previous studies have shown that the use of CG is effective in controlling bleeding from the catheter insertion site and reducing infection, reports from Asia or Japan are lacking 14,15 . In addition, the effect of CG on catheter fixation has only been evaluated in studies using catheter length outside the body, and there have been no studies evaluating catheter tip position inside the body, which is supposed to affect the occurrence of complications 16 …”