Effectiveness of cyanoacrylate glue in the fixation of midline catheters and peripherally inserted central catheters in hospitalised adult patients: Randomised clinical trial (CIANO-ETI)

Abstract

Objective: The objective of the study was to assess the efficacy of the use of cyanoacrylate glue (CAG) as a means of securing midline catheters and peripherally inserted central catheters with the modified micro-Seldinger technique in adult hospitalised patients. Methods: Randomised clinical trial with two groups (1:1): control and intervention. The control group received a securement method with a sutureless device plus transparent dressing and the intervention group received the same securement method plus the CAG. The study was approved by the Drug Research Ethics Committee of the Lleida Health Region. Results: A total of 216 patients were assessed. The two groups of the trial were homogenously distributed in terms of sociodemographic and clinical variables. The intervention group had a statistically significant lower incidence of peri-catheter bleeding and/or oozing during the 7-day study period (odds ratio (OR), 0.6; 95% confidence level (CI), 0.44–0.81; p < 0.001) and a statistically significant lower incidence of catheter dislodgements during the first 24 h (OR, 0.2; 95% CI, 0.04–0.91; p = 0.03). There were no statistically significant differences in the incidence of phlebitis (OR, 1.30; 95% CI, 0.60–2.83; p = 0.56) or catheter-related pain (OR, 0.88; 95% CI, 0.40–1.94; p = 0.84). Conclusion: Midline catheters and peripherally inserted central catheters secured with CAG had fewer complications than catheters not secured with this adhesive.

Peripherally inserted central catheter securement with cyanoacrylate glue and bloodstream infection: A retrospective cohort study

“…In general, placement of catheters in vessels with low blood flow increases the risk of thrombosis; in both cases in our study group, catheter migration may have contributed to the thrombosis. Previous studies have shown that the use of CG was effective in reducing bleeding at the puncture site and controlling infection rather than immobilizing the catheter 14–16 . Our study using chest radiographs showed that the use of CG also inhibited catheter tip migration within the body.…”

“…Previous studies have shown that the use of CG was effective in reducing bleeding at the puncture site and controlling infection rather than immobilizing the catheter. [14][15][16] Our study using chest radiographs showed that the use of CG also inhibited catheter tip migration within the body. Because arrhythmias were not monitored, their incidence rate could not be evaluated.…”

“…14,15 In addition, the effect of CG on catheter fixation has only been evaluated in studies using catheter length outside the body, and there have been no studies evaluating catheter tip position inside the body, which is supposed to affect the occurrence of complications. 16 In this study, we aimed to investigate the effect of CG on the suppression of catheter-related complications, such as catheter infection and thrombus formation, at the first institution in Japan to adopt CG for peripherally inserted central catheter (PICC) fixation in acutely ill adult patients. Moreover, we aimed to examine the effect of CG on the suppression of catheter tip migration inside the body using radiography.…”

“…However, although previous studies have shown that the use of CG is effective in controlling bleeding from the catheter insertion site and reducing infection, reports from Asia or Japan are lacking 14,15 . In addition, the effect of CG on catheter fixation has only been evaluated in studies using catheter length outside the body, and there have been no studies evaluating catheter tip position inside the body, which is supposed to affect the occurrence of complications 16 …”

Synthetic Hemostatic Sealants: Effectiveness, Safety and In Vivo Applications

“…In a sample of patients, Arista TM AH powder was applied at the site of anastomosis instead of glue, and a comparison of the two devices was carried out to test their stability and effectiveness at that site of action (Figure 3B). The procedure for stabilization and fixation of the PICCs (peripherally inserted central catheters) took place in the angiography room after identification by ultrasound of the endovascular access site and exclusion of in situ thrombosis [37,38] (Figure 4). If the identified site was affected by venous thrombosis, the other arm was used.…”