Ten-year trends in antibiotic usage at a tertiary care hospital in Korea, 2004 to 2013

Abstract

Background/Aims: This study was performed to evaluate trends in antibiotic usage at a tertiary care hospital in Korea. Methods: This study collated antibiotic prescription data and total patient days for inpatients at a tertiary care hospital in Korea between 2004 and 2013. The consumption of each class of antibiotic was converted to def ined daily dose (DDD)/1,000 patient-days. We defined 3rd generation cephalosporins, 4th generation cephalosporins, β-lactam/β-lactamase inhibitors, and fluoroquinolones as broad-spectrum antibiotics; carbapenems, tigecycline, glycopeptides, oxazolidinone, and polymyxin were defined as antibiotics against multidrug-resistant (MDR) pathogens. Other antibiotic classes were defined as nonbroad-spectrum antibiotics. Results: Mean antibiotic consumption was 920.69 DDD/1,000 patient-days. The proportions of broad-spectrum antibiotics, antibiotics against MDR pathogens, and nonbroad-spectrum antibiotics were 41.8% (384.48/920.69), 3.5% (32.24/920.69), and 54.7% (503.97/920.69), respectively. Consumption of broad-spectrum antibiotics (coefficient for time 0.141; p = 0.049) and antibiotics against MDR pathogens (coefficient for time 0.185; p < 0.001) showed a significant increasing trend over the study period. Nonbroad-spectrum antibiotic consumption showed a significant decreasing trend over the study period (coefficient for time-2.601; p < 0.001). Conclusions: Over the 10-year period, a stepwise increase in the consumption of broad-spectrum antibiotics and antibiotics against MDR pathogens was observed at a tertiary care hospital in Korea. Conversely, during the same period, nonbroad-spectrum antibiotic consumption showed a significant decreasing trend.

Changes in Clinical Characteristics of Community-Acquired Acute Pyelonephritis and Antimicrobial Resistance of Uropathogenic Escherichia coli in South Korea in the Past Decade

“…Similarly, nationwide cefotaxime use increased and was correlated with the increase in the proportion of cefotaxime-resistant E. coli isolates [ 26 ]. In addition, a stepwise increase in the consumption of broad-spectrum antibiotics, such as ESC and FQ, was observed at a Korean hospital over the last decade [ 27 ]. As for the aspect of horizontal transmission, the change in the major clonal type of uropathogenic E. coli strains might have affected the emergence of antimicrobial resistance.…”

Resultados del Programa de Uso Racional de Antimicrobianos en un hospital de México, 2013-2018

“…Kim et al mostraron un aumento en el consumo de antimicrobianos de amplio espectro como cefalosporinas de cuarta generación y de antimicrobianos para cubrir bacterias multirresistentes, como carbapenémicos, glicopéptidos, polimixina y tigeciclina ( 15 ). Este es un comportamiento similar al nuestro; sin embargo, en el caso particular de los carbapenémicos, solo se observó un aumento en el consumo de ertapenem y meropenem, ya que en el caso de imipenem la disminución es evidente.…”

Human resources required for antimicrobial stewardship activities for hospitalized patients in Korea

“…A similar distribution was observed for patients in general wards. In comparison, 'appropriate antibiotics recommendation for patients with suspected infections without a proven site of infection but without causative pathogens' (37.4%) was most commonly observed in patients in intensive care units, followed by 'appropriate antibiotics recommendation for patients with suspected infections with a proven site of infection and Without a proven site of infection or causative pathogens 14 (11)(12)(13)(14)(15)(16)(17) 14 (11.25-19.25) 13 (11)(12)(13)(14)(15) .784…”