Ten-Year, Thirty-Year, and Lifetime Cardiovascular Disease Risk Estimates Following a Pregnancy Complicated by Preeclampsia

Smith, Graeme N.; Pudwell, Jessica; Walker, Mark; Wen, Shi-Wu

doi:10.1016/s1701-2163(16)35381-6

Cited by 91 publications

(80 citation statements)

References 17 publications

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“…It would be interesting to assess whether the pattern of postpartum PPA differs in complicated versus uncomplicated pregnancies, given that women with history of PrE remain at higher risk of hypertension and premature CV disease as early as 10 years postpregnancy. 4,5 Although no significant changes in AIx and SEVR were observed during pregnancy, we report a sharp increase in AIx and SEVR postpartum when compared to gestational weeks 34 to 40. A previous longitudinal study found an increase in AIx during pregnancy, which persisted at 6.5 weeks postpartum.…”

Section: After Deliverycontrasting

confidence: 52%

“…A previous longitudinal study found an increase in AIx during pregnancy, which persisted at 6.5 weeks postpartum. 3,5 This response may be masked in our study by the recruitment across trimesters. However, the increased AIx postpartum is clear and might indicate greater wave reflection shortly postpartum.…”

Section: After Deliverymentioning

confidence: 94%

“…1,2 Yearly, over 8 million pregnancies are affected by preeclampsia (PrE), 3 and women who previously had PrE are at increased risk of cardiovascular (CV) events later in life. 4,5 Although the placenta is the central organ of the pathogenesis, PrE is increasingly accepted to mainly affect the maternal endothelium. 6 Arterial stiffness is a composite indicator of vascular health that can independently predict CV disease and events: Increased arterial stiffness is associated with a higher CV risk.…”

Section: Introductionmentioning

confidence: 99%

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Pulse Pressure Amplification and Arterial Stiffness in Low-Risk, Uncomplicated Pregnancies

et al. 2015

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Section: After Deliverycontrasting

confidence: 52%

Section: After Deliverymentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Pulse Pressure Amplification and Arterial Stiffness in Low-Risk, Uncomplicated Pregnancies

et al. 2015

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“…4 Moreover, women with pre-eclampsia are at increased risk of cardiovascular disease later in life. 5, 6 …”

Section: Introductionmentioning

confidence: 99%

Hypertension, snoring, and obstructive sleep apnoea during pregnancy: a cohort study

O’Brien

Bullough

Chames

et al. 2014

BJOG

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Objective To assess the frequency of obstructive sleep apnea among women with and without hypertensive disorders of pregnancy. Design Cohort study. Setting Obstetric clinics at an academic medical center. Population Pregnant women with hypertensive disorders (chronic hypertension, gestational hypertension, or pre-eclampsia) and normotensive women. Methods Women completed a questionnaire about habitual snoring and underwent overnight ambulatory polysomnography. Main Outcome Measures The presence and severity of obstructive sleep apnea. Results Obstructive sleep apnoea was found among 21 of 51 women with hypertensive disorders (41%), but in only three of 16 women who were normotensive (19%, chi-square test, P = 0.005). Non-snoring hypertensive women typically had mild obstructive sleep apnea but >25% of snoring hypertensive women had moderate-to-severe obstructive sleep apnea. Among the hypertensive women, the mean apnea/hypopnea index was substantially higher in snorers than non-snorers (19.9±34.1 vs. 3.4±3.1, p=0.013) and the oxyhemoglobin saturation nadir was significantly lower (86.4±6.6 vs. 90.2±3.5, p=0.021). Among hypertensive women, after stratification by obesity the pooled relative risk for obstructive sleep apnea in snoring women with hypertension compared to non-snoring hypertension was 2.0 [95%CI 1.4–2.8]. Conclusions Pregnant women with hypertension are at high risk for unrecognised obstructive sleep apnea. While longitudinal and intervention studies are urgently needed, it would seem pertinent given the known relationship between obstructive sleep apnea and hypertension in the general population, that hypertensive pregnant women who snore should be tested for obstructive sleep apnea, a condition believed to cause or promote hypertension.

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“…Considering that the reports in the literature are included in a time span of 10 years for the emergence of CVD in women who had previous PE [13], it is justified the choice of five-year time interval in the current research, in order to evidence the existence of cardiovascular risk factors earlier in this population. In order to implement preventive measures that may to minimize the morbidity and mortality from CVD.…”

Section: Methodsmentioning

confidence: 99%

Metabolic Syndrome: Individual Components in Women who Had Preeclampsia History and Normal Risk Pregnancy

et al. 2016

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Introduction: Preeclampsia is a serious complication of pregnancy and childbirth that can contribute to the late onset of cardiovascular risk factors, among which the metabolic syndrome.Objective: Identifying the prevalence of metabolic syndrome and its individual components in women who had preeclampsia and normal risk of pregnancy, evaluated five years after delivery.Method: Analytical and descriptive, cross-sectional study with data collection conducted from March to December 2011 in a maternity hospital school, Natal-RN-Brazil. The sample included 70 women who had previous preeclampsia and 75 with normal pregnancy, selected by simple random probability sampling method.Results: It appeared as a cardiovascular risk factor, with statistical significance for metabolic syndrome p = 0.042, but also the fasting glucose levels p = 0.030, HDL cholesterol p = 0.049, systolic and diastolic pressure p <0.001. Conclusion:Therefore, preeclampsia appears as a potential risk factor for metabolic syndrome, hence as long-term cardiovascular risk factor.

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Ten-Year, Thirty-Year, and Lifetime Cardiovascular Disease Risk Estimates Following a Pregnancy Complicated by Preeclampsia

Cited by 91 publications

References 17 publications

Pulse Pressure Amplification and Arterial Stiffness in Low-Risk, Uncomplicated Pregnancies

Pulse Pressure Amplification and Arterial Stiffness in Low-Risk, Uncomplicated Pregnancies

Hypertension, snoring, and obstructive sleep apnoea during pregnancy: a cohort study

Metabolic Syndrome: Individual Components in Women who Had Preeclampsia History and Normal Risk Pregnancy

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