Ten year results of a randomised trial comparing two conservative treatment strategies for small size breast cancer

Mariani, Luigi; Salvadori, B; Marubini, Ettore; Conti, A.; Rovini, Dario; Cusumano, F; Rosolin, T; Andreola, Salvatore; Zucali, R; Rilke, F; Veronesi, Umberto

doi:10.1016/s0959-8049(98)00137-3

Cited by 67 publications

(31 citation statements)

References 12 publications

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“…The adoption of an extensive breast resection (quadrantectomy) as a standard procedure in breast conserving surgery keeps the incidence of positive surgical margins to very low rates. Moreover, data from different studies show that margin positivity does not influence the rate of local recurrences if effective radiotherapy is delivered [46][47]. We had six cases with positive margins (two with in situ neoplasia) and 48 cases with cancer "close to the margins" that were not re-resected.…”

Section: Distant Events and Deathsmentioning

confidence: 99%

Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons

Veronesi

Orecchia

Luini

et al. 2010

Breast Cancer Res Treat

195

117

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Section: Distant Events and Deathsmentioning

confidence: 99%

Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons

Veronesi

Orecchia

Luini

et al. 2010

Breast Cancer Res Treat

195

117

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“…We perform a wide local excision which is just short of a quadrantectomy as this offers a better chance of attaining a negative margin. It has been proven by the Milan 2 trial [6] that wide local excision or quadrantectomy can achieve a statistically significant better local control than a limited conservative procedure such as lumpectomy. Frozen section was used to ascertain the negativity of the margins in most patients.…”

Section: Discussionmentioning

confidence: 99%

Oncological Safety of Breast Conservation Surgery in Young Females

Muralee

Mathew

Cherian

et al. 2016

Indian J Surg Oncol

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Breast conservation surgery (BCS) is the standard of care in early breast cancer. The oncological safety of this procedure has been proven beyond doubt in several randomised control trials. But there are concerns regarding the safety of this procedure in young females. The concern is regarding increased risk of local recurrence. This issue has not been addressed in any major trial. In this prospective study we intend to look into the oncological safety of BCS in young patients who are less than forty years of age.

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“…Details of repeat MRI findings are displayed in Appendix 15 (Clinical significance of < 5-mm MRI-only-detected lesions: repeat MRI findings) for those patients who underwent a repeat scan. Median time from randomisation to repeat MR scan was 15 months (range [8][9][10][11][12][13][14][15][16][17][18][19]. Median time from starting adjuvant radiotherapy to repeat scan was 13 months (range 4-17) for the 12 patients who received radiotherapy.…”

Section: Mri-only-detected Lesions < 5 MMmentioning

confidence: 99%

“…Important excluding factors include: lesions greater than 4 cm in diameter; multifocal or multicentric disease; an extensive in situ component; widespread lymphovascular invasion on biopsy; and centrally placed tumours in small breasts. The Milan II trial, 8 which compared quadrantectomy versus WLE, both followed by radiotherapy, demonstrated that although cosmesis was improved in the WLE group, this was at the expense of a marked increase in loco-regional recurrence (18.6% versus 7.4% 10-year crude cumulative incidence) due to increased incidence of positive excision margins (16% versus 4% in the quadrantectomy group).…”

Section: Introductionmentioning

confidence: 99%

Multicentre randomised controlled trial examining the cost-effectiveness of contrast-enhanced high field magnetic resonance imaging in women with primary breast cancer scheduled for wide local excision (COMICE)

Turnbull

Brown²,

Olivier³

et al. 2010

Health Technol Assess

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on behalf of the COMICE Trial GroupHow to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address. Paying by credit cardYou can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume. How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are ...

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Ten year results of a randomised trial comparing two conservative treatment strategies for small size breast cancer

Cited by 67 publications

References 12 publications

Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons

Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons

Oncological Safety of Breast Conservation Surgery in Young Females

Multicentre randomised controlled trial examining the cost-effectiveness of contrast-enhanced high field magnetic resonance imaging in women with primary breast cancer scheduled for wide local excision (COMICE)

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