Ten-Year Incidence of Retinal Nerve Fiber Layer Defects: The Beijing Eye Study 2001/2011

Ren, Jie; Xu, Liang; Wang, Ya Xing; Zhang, Li; You, Qi Sheng; Yang, Hua; Jonas, Jost B.

doi:10.1167/iovs.15-16682

Cited by 10 publications

(14 citation statements)

References 37 publications

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“…The incidence of localized RNFLDs in an adult Chinese population was 4.7% ± 0.2%, and 44% of those cases had glaucoma or were glaucoma suspects. RNFLDs were strongly associated with arterial hypertension and higher prevalence of cerebrovascular infarcts, in addition to glaucoma and diabetic retinopathy [27]. Similarly, RNFLDs with their central ends at the disc margin were found in 14 and 11 eyes of subjects with or without glaucomatous optic disc appearance, respectively, in the control group in our study.…”

Section: Plos Onesupporting

confidence: 77%

The association of primary aldosteronism with glaucoma-related fundus abnormalities

et al. 2020

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Purpose To elucidate glaucoma-related fundus abnormalities in patients with primary aldosteronism (PA). Methods The study compared 272 eyes from 137 PA patients and 352 eyes from 177 control subjects selected randomly from 1173 participants of a public glaucoma screening. The presence of glaucomatous optic disc appearance (rim thinning and cup enlargement) and retinal nerve fiber layer defects (RNFLDs) was determined independently from fundus photographs. The results were compared between the PA and control groups. Results There were 9 patients (6.6%) with glaucomatous optic disc abnormalities in the PA group and 10 cases (5.6%) identified in the control group (p = 0.92). RNFLDs were detected more frequently in the PA group (55 eyes, 20.2%) than in the control group (26 eyes, 7.4%; p<0.001). The two types of RNFLDs were classified as either having their central ends at the disc margin (D) or away from the disc margin and around the retinal vessels (V). Type D and V RNFLDs were detected in 35 (12.9%) and 26 (9.6%) eyes in the PA group and in 25 (7.1%) and 4 (1.1%) eyes in the control group, respectively. Both types of RNFLDs were more frequent in the PA group than in the control group (Type D and V, p = 0.03, <0.001, respectively). Conclusion Although the prevalence of glaucomatous optic disc appearance did not differ between the two groups, RNFLDs were more frequent in PA patients than in the control group. Moreover, RNFLDs with their central ends located around retinal vessels were characteristic of PA patients.

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Section: Plos Onesupporting

confidence: 77%

The association of primary aldosteronism with glaucoma-related fundus abnormalities

et al. 2020

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“…RNFL defects are one of the early signs of neurodegenerative changes in diabetes. [2, 13] However, RNFL defects also reflect systemic conditions such as arterial hypertension,[15] stroke,[17] and small vessel disease. [16].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the presence of an RNFL defect indicates a pathological change, and is a highly specific marker for optic nerve head abnormalities. [13, 14] The presence of RNFL defects has been associated with several conditions such as arterial hypertension [15], small vessel disease, [16] cerebrovascular infarction,[17] and glaucoma. [15] In type 2 diabetes patients, the RNFL defects that develop in the early stages of retinal changes have been associated with increased urinary albumin excretion.…”

Section: Introductionmentioning

confidence: 99%

“…[13, 14] The presence of RNFL defects has been associated with several conditions such as arterial hypertension [15], small vessel disease, [16] cerebrovascular infarction,[17] and glaucoma. [15] In type 2 diabetes patients, the RNFL defects that develop in the early stages of retinal changes have been associated with increased urinary albumin excretion. [18] Also, the location of RNFL defects during diabetes is associated with diabetic peripheral neuropathy and cardiovascular autonomic neuropathy (CAN).…”

Section: Introductionmentioning

confidence: 99%

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Early inner retinal thinning and cardiovascular autonomic dysfunction in type 2 diabetes

et al. 2017

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BackgroundTo investigate changes in the neural retina according to the presence of retinal nerve fiber layer (RNFL) defects in type 2 diabetes, and to determine the association between inner retina thickness and the severity of diabetic complications.MethodsWe studied non-glaucomatous patients with type 2 diabetes and control subjects Circumpapillary RNFL and macula ganglion cell-inner plexiform layer (GCIPL) thicknesses were measured by spectral-domain optical coherence tomography. In patients with type 2 diabetes, a cardiovascular autonomic function test (AFT) was performed, which included the heart rate parameter of beat-beat variation—with deep breathing, in response to the Valsalva maneuver, and on postural change from lying to standing. The results of each test were scored as 0 for normal and 1 for abnormal. A total AFT score of 1 was defined as early cardiovascular autonomic neuropathy (CAN), and an AFT score≥ 2 as definite CAN.ResultsWe compared control eyes (n = 70), diabetic eyes with RNFL defects (n = 47), and eyes without RNFL defects (n = 30). The average RNFL and GCIPL thicknesses were significantly different among groups (all, P<0.05). On post-hoc testing, diabetic eyes with RNFL defects had a significantly thinner average GCIPL thickness than those without RNFL defects. On multivariate analyses, significantly thinner average GCIPL was seen in early CAN staging (B = -4.32, P = 0.016) and in definite CAN staging (B = -10.33, P<0.001), compared with no CAN involvement, after adjusting for confounding parameters.ConclusionsCardiovascular autonomic dysfunction was associated with early neurodegenerative changes in type 2 diabetes.

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“…Retinal nerve fiber layer (RNFL) abnormalities, manifesting as thinning or defects, are frequently encountered in subjects with diabetes. [3][4][5] Thinning of the RNFL around the optic disc and macula thinning have been reported, and these changes often occur before the development of DR. 3,[6][7][8][9] Retinal nerve fiber layer defects, first described by Hoyt et al 10 50 years ago, is one of the pathognomic findings in glaucomatous optic neuropathy. The RNFL defect may precede detectable changes on the optic disc and visual field (VF), 11 and RNFL-based assessments have been reported to be superior to optic disc-based assessments for the diagnosis of glaucoma.…”

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confidence: 99%

Characteristics of Retinal Nerve Fiber Layer Defect in Nonglaucomatous Eyes With Type II Diabetes

Jeon

Kwon

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To investigate the characteristics of retinal nerve fiber layer (RNFL) defects associated with type II diabetes.METHODS. Forty nonglaucomatous eyes with type II diabetes and 54 eyes with early open angle glaucoma that exhibited a localized RNFL defect and 42 eyes from age-and sex-matched nondiabetic, nonglaucomatous controls were imaged with red-free fundus photography and optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec). The area under the receiver operating characteristic curves of eyes with diabetes was compared with that of eyes with glaucoma. When an RNFL defect on fundus photographs was identified in the quadrant, clock-hour, temporal-superior-nasal-inferior-temporal (TSNIT), deviation, and thickness maps, it was considered a true detection. RESULTS.In eyes with diabetes, the RNFL defects were located more frequently in the superior hemisphere than they were in those with glaucoma (P < 0.001). The angular locations of RNFL defects in eyes with diabetes (56.1 6 12.78) were significantly farther from the fovea compared with those in glaucoma (44.3 6 17.38; P < 0.001); in addition, the width of RNFL defects in diabetes (5.1 6 2.38) was significantly narrower than those in glaucoma (20.8 6 12.38; P < 0.001). The best parameter discriminating RNFL defects in diabetes from those in glaucoma was width of RNFL defect (0.955), followed by rim area (0.844), and average RNFL (0.791). The thickness map showed a sensitivity (70%) and specificity (69.1%), superior to those of all other maps in eyes with diabetes.CONCLUSIONS. The narrow width and identification of RNFL defect in thickness map obtained with Cirrus HD-OCT seems to be an effective tool for detecting RNFL defects in diabetes.

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Ten-Year Incidence of Retinal Nerve Fiber Layer Defects: The Beijing Eye Study 2001/2011

Cited by 10 publications

References 37 publications

The association of primary aldosteronism with glaucoma-related fundus abnormalities

The association of primary aldosteronism with glaucoma-related fundus abnormalities

Early inner retinal thinning and cardiovascular autonomic dysfunction in type 2 diabetes

Characteristics of Retinal Nerve Fiber Layer Defect in Nonglaucomatous Eyes With Type II Diabetes

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