Ten bright-white fingernails in two young healthy patients

Clayton, N.; Atkar, Ravinder; Verdolini, Roberto

doi:10.1111/j.1365-2230.2011.04084.x

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…Our patient history revealed unprotected exposure of the hands to detergents, and also she had low zinc level. Although zinc deficiency has been mentioned as a cause of leukonychia in different studies and should be kept in mind while managing the cases of leukonychia,[789] it affects all parts of nail plate not only lateral portions. We hypothesize that the accumulation of these chemicals in the lateral nail folds facilitated their spread to the nail matrix and caused injury to the lateral matrix due to their poisonous nature against the active cells of the matrix (direct effect).…”

Section: Discussionmentioning

confidence: 99%

Acquired bilateral longitudinal true leukonychia in a 35-year-old woman

et al. 2016

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Acquired bilateral longitudinal true leukonychia is a rare disorder. We present a case of a 35-year-old healthy woman presented with this unusual and rare manifestation. She mentioned a history of unprotected exposure to detergents and bleaching chemical agents. Considering her low zinc level, she was prescribed with zinc capsules and recommended to avoid chemical substances for 6 months. During bimonthly follow-up, her zinc level turned normal, and leukonychia subsequently disappeared. Bilateral longitudinal true leukonychia in the nails due to zinc deficiency and exposure to chemical substances has not been reported previously. Direct and indirect effects of chemical substances on matrix and the effect of zinc deficiency on healing process should be considered in these cases.

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Section: Discussionmentioning

confidence: 99%

Acquired bilateral longitudinal true leukonychia in a 35-year-old woman

et al. 2016

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“…7 In a family study, Clayton et al found that the genetic defect underlying leukonychia in the family resided on chromosome 12q13, which is the chromosome containing the genes encoding basic keratin proteins, and postulated that a mutation in one of the keratin genes may be a cause of hereditary leukonychia. 2,8 Partial leukonychia is considered a variant of TL as patients often present with PL and TL at different stages. The former indicates that the nail matrix demonstrates alternate periods of normal and abnormal keratinization.…”

Section: Editormentioning

confidence: 99%