Temporomandibular disorders in children and adolescents: A review

Mélou, Caroline; Sixou, J.L.; Sinquin, C.; Chauvel‐Lebret, Dominique

doi:10.1016/j.arcped.2023.03.005

Cited by 7 publications

(2 citation statements)

References 64 publications

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“…The candidate mediators included nine psychology‐related traits (depression, feeling lonely, miserable, guilty, fed‐up, nervous, worry, hurt, and tense), 19,20 four smoking and dietary behaviours (ever smoked, smoking initial, cigarettes smoked per day, alcohol intake frequency), 21 three adiposity traits (body mass index [BMI], waist‐to‐hip ratio [WHR], body fat percentage), 22 five sleep‐related traits (apnea, snoring, insomnia, daytime sleepiness, sleep duration), 23,24 one physical activity (moderate to vigorous physical activity levels), 19 two autoimmune disorders (systemic lupus erythematosus [SLE], Sjogren's syndrome [SS]), 25 insufficient Vitamin D (vitamin D supplement, serum 25‐Hydroxyvitamin D levels), 25 estradiol levels in females and males, 26 lower back pain 27 and average total household income 28 . Detailed information on all GWAS included in our study is shown in Table S2.…”

Section: Methodsmentioning

confidence: 99%

Causal effects of educational attainment on temporomandibular disorders and the mediating pathways: A Mendelian randomization study

Chen,

Cheng,

et al. 2024

J of Oral Rehabilitation

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BackgroundAs one of the most important indicators of socioeconomic status, educational attainment (EA) exhibits a strong association with temporomandibular disorders (TMDs). Despite this link, there is a lack of evidence regarding the causal role of EA in either facilitating or preventing TMDs.ObjectiveThis study aimed to investigate the causal effect of education on TMDs and explore potential mediating pathways.MethodsUtilizing summary statistics from genome‐wide association studies on years of schooling (N = 766 345) and TMDs (N = 211 023), we conducted Mendelian randomization (MR) to assess the overall effect of education. Additionally, a two‐step MR approach was employed to evaluate 30 potential mediators and calculate the mediation proportions in the association. Comprehensive sensitivity analyses were used to verify the robustness, heterogeneity, and pleiotropy.ResultsUnivariable MR analyses revealed a causal effect of lower EA on an increased risk of TMDs (OR: 0.53, 95% CI: 0.43–0.66, p < .001). Five out of 30 modifiable factors were identified as causal mediators in the associations of EA with TMDs, including feeling nervous (mediation proportion: 11.6%), feeling tense (10.2%), depression (9.6%), feeling worry (7.6%) and daily smoking (8.9%). Meanwhile, no pleiotropy was detected in the analyses (p > .05).ConclusionOur findings supported that higher EA has a protective effect on the onset of TMDs, with partial mediation by psychological disorders and daily smoking. Interventions on these factors thus have the potential of substantially reducing the burden of TMDs attributed to low education.

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Section: Methodsmentioning

confidence: 99%

Causal effects of educational attainment on temporomandibular disorders and the mediating pathways: A Mendelian randomization study

Chen,

Cheng,

et al. 2024

J of Oral Rehabilitation

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“…However, these treatments also have disadvantages. An occlusal splint can be complex, especially in mixed dentition cases [18]. Moreover, it was also demonstrated that an occlusal splint combined with physiotherapy can induce craniovertebral and craniomandibular changes in TMD patients, namely the vertical and sagittal position of the mandible and the width of the functional space between C1 and C2 [19].…”

Section: Introductionmentioning

confidence: 99%

Temporomandibular Joint Minimally Invasive Procedures in the Pediatric Population: A Prospective Study

Ângelo,

Lopes,

Sanz

et al. 2024

JCM

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Over recent years, temporomandibular joint (TMJ) minimally invasive procedures, such as arthrocentesis and arthroscopy, have been appointed as an initial TMJ intra-articular treatment. Both procedures present safe and effective clinical results in managing temporomandibular disorders (TMD) by reducing pain and improving mouth opening. The use of these techniques in adults is validated in the literature. However, data on the safety and effectiveness of minimally invasive TMJ interventions in pediatric patients are scarce. This study aims to investigate the effectiveness of TMJ arthrocentesis and arthroscopy in the pediatric population. A prospective study was conducted at Instituto Português da Face (IPF) in Lisbon, Portugal, including patients treated for TMD from 1 June 2019 to 30 June 2023. In the present study, 26 patients (17 female and 9 male) were included, representing a total of 48 joints operated. A statistically significant reduction was observed in the primary outcome, TMJ pain, from 3.93 ± 2.80 preoperatively (mean ± SD) to 0.50 ± 1.53 (mean ± SD) postoperatively (p < 0.05). An improvement in the secondary outcome, maximum mouth opening, from 36.92 ± 8.79 preoperatively to 42.96 ± 5.07 postoperatively, was observed (p < 0.05). The overall success rate was 84.62%. This prospective study showed that TMJ arthrocentesis and arthroscopy appear to benefit pediatric patients with TMD, significantly lowering pain and improving MMO without relevant postoperative complications.

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Causal effects of life course adiposity on temporomandibular disorders: A Mendelian randomization study

Chen,

Cheng,

et al. 2023

J of Oral Rehabilitation

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BackgroundPrevious studies investigated the associations between obesity and temporomandibular disorders (TMDs), but the evidence for the causal inferences was unclear.ObjectiveWe aimed to investigate the causal link between life course adiposity and TMDs.MethodsMendelian randomization (MR) studies were performed using genetic instruments for birth weight (BW) (N = 261 932), childhood body mass index (BMI) (N = 39 620), childhood body size (N = 454 718), adult BMI (N = 99 998), body fat percentage (N = 454 633) and TMDs (N = 211 023). We assessed the overall effect of each life course adiposity factor via inverse‐variance weighted (IVW), weighted median, and MR‐Egger methods and performed extensive sensitivity analyses. Additionally, multivariable MR was conducted to evaluate the direct and indirect effects of childhood BMI on TMDs while accounting for BW and adult BMI, and vice versa.ResultsUnivariable MR analyses revealed a causal effect of low childhood adiposity on an increased risk of TMDs (childhood BMI: IVW OR: 0.65, 95% CI: 0.54–0.78, p < .001; childhood body size: IVW OR: 0.56, 95% CI: 0.43–0.73, p < .001). No causal association existed between genetically predicted BW, adult BMI, or body fat percentage and TMDs. In the multivariable MR analyses, the effects of childhood BMI on TMDs occurrence remained significant and direct, even after adjusting for BW and adult BMI (multivariable IVW OR: 0.78, 95% CI: 0.61–0.99, p = .048). No pleiotropy and heterogeneity were detected (p > .05).ConclusionLow childhood BMI might causally increase the risk of TMDs through a direct pathway.

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Temporomandibular disorders in children and adolescents: A review

Cited by 7 publications

References 64 publications

Causal effects of educational attainment on temporomandibular disorders and the mediating pathways: A Mendelian randomization study

Causal effects of educational attainment on temporomandibular disorders and the mediating pathways: A Mendelian randomization study

Temporomandibular Joint Minimally Invasive Procedures in the Pediatric Population: A Prospective Study

Causal effects of life course adiposity on temporomandibular disorders: A Mendelian randomization study

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