Temporomandibular Disorders Clinical and Anatomical Outcomes After Fat-Derived Stem Cells Injection

Carboni, Alessia; Amodeo, Giulia; Perugini, Maurizio; Arangio, Paolo; Orsini, Raniero; Scopelliti, Domenico

doi:10.1097/scs.0000000000004884

Cited by 15 publications

(50 citation statements)

References 25 publications

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“…These results proved that the use of ASCs, especially predifferentiated with TGF-β1 in TMJ engineering, promoted fibrocartilaginous TMJ disclike tissue formation [104]. More recently, a study obtained positive outcomes after autologous ASC infiltration in the TMJ superior compartment of patients suffering from temporomandibular disorders [105]. They found that ASC injections with arthrocentesis led to the alleviation of symptoms and restoration of articular anatomical integrity, as demonstrated by MRI findings.…”

Section: Adipose Stem Cells (Ascs)mentioning

confidence: 80%

An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis

Zhao

Xie

2021

Stem Cells International

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Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease characterized by cartilage degeneration, disrupted subchondral bone remodeling, and synovitis, seriously affecting the quality of life of patients with chronic pain and functional disabilities. Current treatments for TMJOA are mainly symptomatic therapies without reliable long-term efficacy, due to the limited self-renewal capability of the condyle and the poorly elucidated pathogenesis of TMJOA. Recently, there has been increased interest in cellular therapies for osteoarthritis and TMJ regeneration. Mesenchymal stem cells (MSCs), self-renewing and multipotent progenitor cells, play a promising role in TMJOA treatment. Derived from a variety of tissues, MSCs exert therapeutic effects through diverse mechanisms, including chondrogenic differentiation; fibrocartilage regeneration; and trophic, immunomodulatory, and anti-inflammatory effects. Here, we provide an overview of the therapeutic roles of various tissue-specific MSCs in osteoarthritic TMJ or TMJ regenerative tissue engineering, with an additional focus on joint-resident stem cells and other cellular therapies, such as exosomes and adipose-derived stromal vascular fraction (SVF). Additionally, we summarized the updated pathogenesis of TMJOA to provide a better understanding of the pathological mechanisms of cellular therapies. Although limitations exist, MSC-centered therapies still provide novel, innovative approaches for TMJOA treatment.

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Section: Adipose Stem Cells (Ascs)mentioning

confidence: 80%

An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis

Zhao

Xie

2021

Stem Cells International

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“…The full texts of these 40 manuscripts were analyzed for inclusion individually by the same authors, and nine manuscripts were found relevant for inclusion (in vitro). Reasons for exclusions were as follows: the authors used animal cells ( n = 18), or it was an animal model study ( n = 1), or not TMJ related ( n = 7), or not TMJ regeneration ( n = 2), or in vivo study (Carboni et al., 2019; De Riu et al., 2019; Howlader et al., 2017) ( n = 3). PRISMA flowchart shows a summary of our results (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…Carboni et al. (2019) found significant improvement of TMD related symptoms in four patients with internal derangement of TMJ, who received stem cell injections as compared to controls with saline injection only. They also found MRI evidence of restoration of defective TMJ structures in stem cell group.…”

Section: Introductionmentioning

confidence: 99%

“…Growth factors such as IGF, bFGF, VEGF secreted by stem cells can participate in various levels of tissue regeneration, most importantly, stimulate bone regeneration (Tomoyasu et al., 2007). A few in vivo human studies (Carboni et al., 2019; De Riu et al., 2019; Howlader et al., 2017) have demonstrated the regenerative potential of stem cells in TMJ repair. Carboni et al.…”

Section: Introductionmentioning

confidence: 99%

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Regeneration of temporomandibular joint using in vitro human stem cells: A review

Gong

Emperumal

Al‐Eryani

et al. 2022

J Tissue Eng Regen Med

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Temporomandibular joint disorders (TMDs) range from gross anatomic deformities of the disc and hard tissue to functional disturbances. Traditional treatment of TMDs includes physical therapy, use of appliances, pharmacological, surgical and psychological interventions. However, during the late stage of TMDs, conventional management often results in inadequate relief of symptoms. Stem cell-based tissue regeneration has been studied extensively in joint regeneration, including the Temporomandibular Joint (TMJ). This study aims to review the potential of various human stem cells (HSC) for the regeneration of the TMJ. In vitro studies using human mesenchymal stem cells cultured under different conditions to evaluate regeneration of TMJ related structures were searched on PubMed, EMBASE, Cochrane, and Web of Science up to March 2020. In vitro studies utilized several different types of stem cells under varying conditions. Increased osteogenesis and/ or chondrogenesis were noted with stem cell interventions compared to control groups on Alkaline Phosphatase (ALP) activity, Col-I, Col-II, Col-X, RUNX2, LPL, and Aggrecan mRNA expression. This review emphasizes the potential of stem cell therapies in the regeneration of TMJ-related structures. However, further in vivo studies are required to evaluate the efficacy and safety of these therapies in humans. K E Y W O R D S in vitro, mesenchymal stem cells, review, stem cell therapies, temporomandibular disorders, temporomandibular joint 1 | INTRODUCTION The temporomandibular joint (TMJ) is a complex synovial joint with a unique articulation between the temporal glenoid fossa and the mandibular condyle, which are separated by an articular disc composed of avascular and non-innervated dense fibrous connective tissue with a varying amount of fibrocartilage. The articular disc divides the TMJ cavity into upper and lower chambers. Gliding movement occurs in the upper chamber during the maximal mouth opening, while the lower chamber function primarily as a hinge or rotary movement in the early opening. Because the TMJ has a hinge and sliding movable socket, it is classified as ginglymoarthrodial a joint. The TMJ is surrounded by a fibrous connective tissue capsule attached to muscles and tendons. The capsule is lined by a synovium This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…Carboni et al analyzed the effect of the injection of fat-derived stromal cells in the temporomandibular joint as a new treatment option for TMD [ 38 ]. Eight patients were randomized into two groups.…”

Section: Discussionmentioning

confidence: 99%

Temporomandibular Joint Osteoarthritis: Regenerative Treatment by a Stem Cell Containing Advanced Therapy Medicinal Product (ATMP)—An In Vivo Animal Trial

Köhnke

Ahlers

Birkelbach

et al. 2021

IJMS

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Temporomandibular joint osteoarthritis (TMJ-OA) is a chronic degenerative disease that is often characterized by progressive impairment of the temporomandibular functional unit. The aim of this randomized controlled animal trial was a comparative analysis regarding the chondroregenerative potency of intra-articular stem/stromal cell therapy. Four weeks after combined mechanical and biochemical osteoarthritis induction in 28 rabbits, therapy was initiated by a single intra-articular injection, randomized into the following groups: Group 1: AB Serum (ABS); Group 2: Hyaluronic acid (HA); Group 3: Mesenchymal stromal cells (STx.); Group 4: Mesenchymal stromal cells in hyaluronic acid (HA + STx.). After another 4 weeks, the animals were euthanized, followed by histological examination of the removed joints. The histological analysis showed a significant increase in cartilage thickness in the stromal cell treated groups (HA + STx. vs. ABS, p = 0.028; HA + ST.x vs. HA, p = 0.042; STx. vs. ABS, p = 0.036). Scanning electron microscopy detected a similar heterogeneity of mineralization and tissue porosity in the subchondral zone in all groups. The single intra-articular injection of a stem cell containing, GMP-compliant advanced therapy medicinal product for the treatment of iatrogen induced osteoarthritis of the temporomandibular joint shows a chondroregenerative effect.

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Temporomandibular Disorders Clinical and Anatomical Outcomes After Fat-Derived Stem Cells Injection

Cited by 15 publications

References 25 publications

An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis

An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis

Regeneration of temporomandibular joint using in vitro human stem cells: A review

Temporomandibular Joint Osteoarthritis: Regenerative Treatment by a Stem Cell Containing Advanced Therapy Medicinal Product (ATMP)—An In Vivo Animal Trial

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