Temporal variability of T‐wave morphology and risk of sudden cardiac death in patients with coronary artery disease

Rahola, Janne T.; Kiviniemi, Antti M.; Ukkola, Olavi; Tulppo, Mikko P.; Junttila, M. Juhani; Kenttä, Tuomas; Perkiömäki, Juha S.

doi:10.1111/anec.12830

Cited by 5 publications

(5 citation statements)

References 28 publications

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“…Guidelines currently suggest clinical and exercise capacity assessments in combination with invasive and non-invasive imaging for risk stratification [ [42] , [43] , [44] , [45] ]. Moreover, QT interval [ 46 ], T-wave morphology dispersion [ 47 ], early repolarization pattern [ 48 ], and total cosine R-to-T [ 49 ] have been found to predict sudden coronary death. However, the sensitivity and specificity for prediction are inadequate.…”

Section: Discussionmentioning

confidence: 99%

Characterization of global research trends and prospects on sudden coronary death: A literature visualization analysis

Luo¹,

Zhao²,

Chen³

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Characterization of global research trends and prospects on sudden coronary death: A literature visualization analysis

Luo¹,

Zhao²,

Chen³

et al. 2023

Heliyon

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“…The deployment of ICD as a prophylactic measure against arrhythmic SCD has become commonplace, yet the prevalence of SCD has not declined despite a steady increase in ICD implantation rates over the past two decades. While non-sustained ventricular tachycardia, ventricular ejection fraction and electrophysiology study-induced programmed stimulation have a high diagnostic yield in identifying individuals at risk for arrhythmic SCD, these markers do not comprehensively account for the population vulnerable to aborted SCD [ 184 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

T-Wave Analysis on the 24 h Holter ECG Monitoring as a Predictive Assessment of Major Adverse Cardiovascular Events in Patients with Myocardial Infarction: A Literature Review and Future Perspectives

Duca

Roca

Costache

et al. 2023

Life

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Myocardial ischemia is a pathophysiological state characterized by inadequate perfusion of the myocardium, resulting in an imbalance between myocardial oxygen demand and supply. It is most commonly caused by coronary artery disease, in which atherosclerotic plaques lead to luminal narrowing and reduced blood flow to the heart. Myocardial ischemia can manifest as angina pectoris or silent myocardial ischemia and can progress to myocardial infarction or heart failure if left untreated. Diagnosis of myocardial ischemia typically involves a combination of clinical evaluation, electrocardiography and imaging studies. Electrocardiographic parameters, as assessed by 24 h Holter ECG monitoring, can predict the occurrence of major adverse cardiovascular events in patients with myocardial ischemia, independent of other risk factors. The T-waves in patients with myocardial ischemia have prognostic value for predicting major adverse cardiovascular events, and their electrophysiological heterogeneity can be visualized using various techniques. Combining the electrocardiographic findings with the assessment of myocardial substrate may offer a better picture of the factors that can contribute to cardiovascular death.

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“…The most explored nosology in relation to DNA methylation is ischemic heart disease [5]. The association of the disease with the global DNA hypermethylation is established.…”

Section: Dna Methylation and Ischemic Heart Diseasementioning

confidence: 99%

“…The dominant SCD cause in adults is chronic degenerative diseases (IHD, valvular heart diseases, heart failure), of which IHD is the first (75%), whereas heart rhythm disturbances and cardiomyopathy are seen less often (15%) [1,4,5]. In younger people and children, SCD development is promoted by cardiomyopathy, congenital heart rhythm disturbances, myocarditis, myocardial ischemia due to coronary vessel pathologies or heart failure.…”

Section: Introductionmentioning

confidence: 99%

Role of DNA Methylation in Development of Cardiovascular Diseases, Resulting in a Sudden Cardiac Death (Review)

Иванова¹,

Maksimova²,

Gurazheva³

2022

Sovrem Tehnol Med

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An effective system to diagnose predisposition to development of sudden cardiac death (SCD) is required in order to determine the risk of developing a sudden fatal outcome well in advance of the onset thereof, including in people with asymptomatic cardiovascular disease, as well as to implement early preventive measures that can result in a decrease in the population mortality from cardiovascular diseases. Thus, the search for SCD risk markers becomes a topical issue for modern health care.According to recent studies, epigenetic mechanisms of heredity, and DNA methylation above all, play an important role in development of many diseases. The review provides the results of recent foreign and Russian studies on identification of a link between DNA methylation and development of cardiovascular diseases being the basis for SCD (IHD, cardiomyopathies, heart rhythm disturbances). The major part of the review is dedicated to studying DNA methylation in IHD, which is the most epigenetically explored nosology at the moment. Attention is also paid to studies of the DNA methylation role in development of acute coronary syndrome and myocardial infarction, which have development mechanisms similar to those of SCD. There were only few studies on identification of a link between DNA methylation and cardiomyopathies and cardiac arrhythmias conducted, however, an association of specific genes methylation with the explored nosologies was revealed. The review also provides pathogenetic substantiations of the possibilities to use epigenetic markers of cardiovascular diseases as SCD markers.Thus, it has been established that study of genes the methylation of which is associated with IHD (CTH, PLCB1, PTX3, MMP9, FN1, F2RL3, ABCB1, FOXP3, GDF15, IL6, CASR), with lipid metabolism disorders and atherosclerosis (CETP, CCL2, SREBF2, TIMP1), as well as with heart rhythm disturbances (SCN5A and KCNQ1), may be most promising in relation to SCD.

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Temporal variability of T‐wave morphology and risk of sudden cardiac death in patients with coronary artery disease

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 5 publications

References 28 publications

Characterization of global research trends and prospects on sudden coronary death: A literature visualization analysis

Characterization of global research trends and prospects on sudden coronary death: A literature visualization analysis

T-Wave Analysis on the 24 h Holter ECG Monitoring as a Predictive Assessment of Major Adverse Cardiovascular Events in Patients with Myocardial Infarction: A Literature Review and Future Perspectives

Role of DNA Methylation in Development of Cardiovascular Diseases, Resulting in a Sudden Cardiac Death (Review)

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