Temporal variability of serum miR-191, miR-223, miR-128, and miR-24 in multiple sclerosis: A 4-year follow-up study

Vistbakka, Julia; Sumelahti, Marja‐Liisa; Lehtimäki, Terho; Hagman, Sanna

doi:10.1016/j.jns.2022.120395

Cited by 2 publications

(2 citation statements)

References 36 publications

(60 reference statements)

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“…Studies have identified certain miRNAs with high abundance in MSCs-Exos that possess unique immunomodulatory effects and are involved in myelin damage and regeneration associated with MS. Examples include miR-122 ( 42 ), miR-21 ( 42 , 43 ), miR-146a ( 44 ), miR-24 ( 45 ), and miR-223 ( 45 , 46 ). To investigate the impact of HUMSCs-Exos on OPC differentiation and maturation, we performed transcriptome sequencing to identify DEGs between HUMSCs-Exos-treated OPCs and untreated OPCs.…”

Section: Discussionmentioning

confidence: 99%

Exosomal miR-23a-3p derived from human umbilical cord mesenchymal stem cells promotes remyelination in central nervous system demyelinating diseases by targeting Tbr1/Wnt pathway

Qin,

Wang,

et al. 2024

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

Exosomal miR-23a-3p derived from human umbilical cord mesenchymal stem cells promotes remyelination in central nervous system demyelinating diseases by targeting Tbr1/Wnt pathway

Qin,

Wang,

et al. 2024

Journal of Biological Chemistry

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“…Further, miR-223-3p could be implemented as a potential marker for disease progression and response to treatment in relation to relapse dynamics. The temporal variability of these miRNAs, along with MRI scans and clinical markers, gives strength to the possibility of clinical implementation and practical usage of these non-coding RNAs in MS pathophysiology [103].…”

Section: Mirnas As Ms Biomarkersmentioning

confidence: 99%

Multiple Sclerosis: Roles of miRNA, lcnRNA, and circRNA and Their Implications in Cellular Pathways

Cipriano,

Schepici,

Mazzon

et al. 2024

IJMS

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Multiple sclerosis (MS) is a degenerative condition characterized by axonal damage and demyelination induced by autoreactive immune cells that occur in the Central Nervous System (CNS). The interaction between epigenetic changes and genetic factors can be widely involved in the onset, development, and progression of the disease. Although numerous efforts were made to discover new therapies able to prevent and improve the course of MS, definitive curative treatments have not been found yet. However, in recent years, it has been reported that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), acting as gene expression regulators, could be used as potential therapeutic targets or biomarkers to diagnose and fight MS. In this review, we discussed the role of miRNAs, lncRNAs, and circRNAs, as well as their expression level changes and signaling pathways that are related to preclinical and human MS studies. Hence, the investigation of ncRNAs could be important to provide additional information regarding MS pathogenesis as well as promote the discovery of new therapeutic strategies or biomarkers.

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Temporal variability of serum miR-191, miR-223, miR-128, and miR-24 in multiple sclerosis: A 4-year follow-up study

Cited by 2 publications

References 36 publications

Exosomal miR-23a-3p derived from human umbilical cord mesenchymal stem cells promotes remyelination in central nervous system demyelinating diseases by targeting Tbr1/Wnt pathway

Exosomal miR-23a-3p derived from human umbilical cord mesenchymal stem cells promotes remyelination in central nervous system demyelinating diseases by targeting Tbr1/Wnt pathway

Multiple Sclerosis: Roles of miRNA, lcnRNA, and circRNA and Their Implications in Cellular Pathways

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