Exosomal miR-23a-3p derived from human umbilical cord mesenchymal stem cells promotes remyelination in central nervous system demyelinating diseases by targeting Tbr1/Wnt pathway

Qin, Danqing; Wang, Chunjuan; Li, Dong; Guo, Shougang

doi:10.1016/j.jbc.2023.105487

Cited by 3 publications

(3 citation statements)

References 61 publications

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“…Also, in our study, we used hUMSc from a depository since they are widely adopted to perform studies about inflammation, cancer and neurologic diseases [54][55][56]. In addition, the results we obtained were similar to those we found from preliminary experiments performed in primary hUMSCs isolated from umbilical cords.…”

Section: Limitationssupporting

confidence: 78%

Plasma Redox Balance in Advanced-Maternal-Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells

Grossini,

Aquino,

Venkatesan

et al. 2024

IJMS

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Pregnancy at advanced maternal age (AMA) is a condition of potential risk for the development of maternal–fetal complications with possible repercussions even in the long term. Here, we analyzed the changes in plasma redox balance and the effects of plasma on human umbilical cord mesenchymal cells (hUMSCs) in AMA pregnant women (patients) at various timings of pregnancy. One hundred patients and twenty pregnant women younger than 40 years (controls) were recruited and evaluated at various timings during pregnancy until after delivery. Plasma samples were used to measure the thiobarbituric acid reactive substances (TBARS), glutathione and nitric oxide (NO). In addition, plasma was used to stimulate the hUMSCs, which were tested for cell viability, reactive oxygen species (ROS) and NO release. The obtained results showed that, throughout pregnancy until after delivery in patients, the levels of plasma glutathione and NO were lower than those of controls, while those of TBARS were higher. Moreover, plasma of patients reduced cell viability and NO release, and increased ROS release in hUMSCs. Our results highlighted alterations in the redox balance and the presence of potentially harmful circulating factors in plasma of patients. They could have clinical relevance for the prevention of complications related to AMA pregnancy.

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Section: Limitationssupporting

confidence: 78%

Plasma Redox Balance in Advanced-Maternal-Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells

Grossini,

Aquino,

Venkatesan

et al. 2024

IJMS

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show abstract

“…In addition, EAE mice injected with placental EVs showed a decrease in T cell proliferation, increase Treg cell, and a subsequent decrease in inflammation adding weight to these findings [ 101 , 102 ]. The same effects were observed in EVs produced from bone marrow, periodontal ligament cells, adipose tissue, and umbilical cord mesenchyme, which raised the levels of protective cytokines, such as IL10, transforming growth factor-beta (TGF-β), and stromal cell-derived factor 1 alpha (SDF-1α), but reduced pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-α) and NALP-3 [ 94 , 96 , 103 - 109 ].…”

Section: Extracellular Vesicles As the Potential Treatment Strategies...mentioning

confidence: 85%

Possible Roles of Extracellular Vesicles in the Pathogenesis and Interventions of Immune-Mediated Central Demyelinating Diseases

Teekaput,

Thiankhaw,

Chattipakorn

et al. 2024

Exp Neurobiol

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Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are two of the most devastating immune-mediated central demyelinating disorders. NMOSD was once considered as a variant of MS until the discovery of an antibody specific to the condition. Despite both MS and NMOSD being considered central demyelinating disorders, their pathogenesis and clinical manifestations are distinct, however the exact mechanisms associated with each disease remain unclear. Extracellular vesicles (EVs) are nano-sized vesicles originating in various cells which serve as intercellular communicators. There is a large body of evidence to show the possible roles of EVs in the pathogenesis of several diseases, including the immune-mediated central demyelinating disorders. Various types of EVs are found across disease stages and could potentially be used as a surrogate marker, as well as acting by carrying a cargo of biochemical molecules. The possibility for EVs to be used as a next-generation targeted treatment for the immune-mediated central demyelinating disorders has been investigated. The aim of this review was to comprehensively identify, compile and discuss key findings from in vitro , in vivo and clinical studies. A summary of all findings shows that: 1) the EV profiles of MS and NMOSD differ from those of healthy individuals, 2) the use of EV markers as liquid biopsy diagnostic tools appears to be promising biomarkers for both MS and NMOSD, and 3) EVs are being studied as a potential targeted therapy for MS and NMOSD. Any controversial findings are also discussed in this review.

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“…MiR-15-5p, which targets FGF-2 [ 64 , 65 ], is significantly increased in plasma exosomes from patients with multiple sclerosis or SPMS [ 66 ]. MiR-23a-3p, which is involved in the regulation of oligodendrocyte differentiation [ 67 ], is significantly increased in the cerebral white matter of MS patients [ 68 ].…”

Section: Exosomes In the Diagnosis Of Demyelinating Diseasesmentioning

confidence: 99%

Exosomes in the Diagnosis of Neuropsychiatric Diseases: A Review

Wu,

Shang,

Guo

et al. 2024

Biology

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Exosomes are 30–150 nm small extracellular vesicles (sEVs) which are highly stable and encapsulated by a phospholipid bilayer. Exosomes contain proteins, lipids, RNAs (mRNAs, microRNAs/miRNAs, long non-coding RNAs/lncRNAs), and DNA of their parent cell. In pathological conditions, the composition of exosomes is altered, making exosomes a potential source of biomarkers for disease diagnosis. Exosomes can cross the blood–brain barrier (BBB), which is an advantage for using exosomes in the diagnosis of central nervous system (CNS) diseases. Neuropsychiatric diseases belong to the CNS diseases, and many potential diagnostic markers have been identified for neuropsychiatric diseases. Here, we review the potential diagnostic markers of exosomes in neuropsychiatric diseases and discuss the potential application of exosomal biomarkers in the early and accurate diagnosis of these diseases. Additionally, we outline the limitations and future directions of exosomes in the diagnosis of neuropsychiatric diseases.

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Exosomal miR-23a-3p derived from human umbilical cord mesenchymal stem cells promotes remyelination in central nervous system demyelinating diseases by targeting Tbr1/Wnt pathway

Cited by 3 publications

References 61 publications

Plasma Redox Balance in Advanced-Maternal-Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells

Plasma Redox Balance in Advanced-Maternal-Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells

Possible Roles of Extracellular Vesicles in the Pathogenesis and Interventions of Immune-Mediated Central Demyelinating Diseases

Exosomes in the Diagnosis of Neuropsychiatric Diseases: A Review

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