Temporal Uptake Patterns of 18F-Fluorocholine Among Hyperfunctioning Parathyroid Glands

Morland, David; Richard, C.; Guilhot, François; Deguelte, Sophie; Delemer, Brigitte

doi:10.1097/rlu.0000000000002132

Cited by 13 publications

(29 citation statements)

References 8 publications

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“…Patients who underwent dual-time-point 18 F-FCH PET/CT for the evaluation of hyperparathyroidism were included in this study when both PET/CT results were positive and PET/CT was followed by surgery and when parathyroid adenoma or hyperplasia was histopathologically proven. All patient data, including baseline characteristics, scan results, and quantitative measurements, were prospectively entered into a database.…”

Section: Patient Selectionmentioning

confidence: 99%

“…For interpretation of the images and quantitative measurements, dedicated software (syngo.via; Siemens Medical Solutions) was used. Patient preparation consisted of hydration with 1 L of water and, if applicable, discontinuation of colchicine 48 h before 18 F-FCH administration. Discontinuation of calcimimetic drugs or other medications was not required.…”

Section: Scan Acquisitionmentioning

confidence: 99%

“…Scanning at both early and late time points has been suggested, and authors have reported lesions that were visualized on early images only (6)(7)(8). The objective of the present study was to evaluate different uptake patterns and differences in the visualization of parathyroid glands on early and late images using dual-timepoint 18 F-FCH PET/CT in patients with hyperparathyroidism.…”

mentioning

confidence: 94%

“…To visualize parathyroid lesions, various morphology-based imaging techniques, such as ultrasonography, CT, and MRI, can be used; however, the current reference method is functional imaging with 99m Tc-sestamibi. Recently, 18 F-fluorocholine ( 18 F-FCH) PET/CT was proposed and investigated as a tool for the detection of hyperfunctioning parathyroid tissue, with promising results (4,5).…”

mentioning

confidence: 99%

“…Although various acquisition protocols have been described, the optimal time point for image acquisition after injection of 18 F-FCH is still under debate. In previous studies, time points ranging from 0 to 120 min after injection were used, with conflicting results.…”

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confidence: 99%

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Dual-Time-Point ¹⁸F-Fluorocholine PET/CT in Parathyroid Imaging

et al. 2019

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18 F-fluorocholine ( 18 F-FCH) PET/CT is a promising and increasingly used scan technique in the preoperative imaging of parathyroid adenoma. Several acquisition methods have been evaluated in the literature, but the optimal image acquisition time point after administration of the tracer is still under debate. Methods: Patients who had hyperparathyroidism, underwent dual-time-point 18 F-FCH PET/ CT (image acquisition, 5 min; 60 min after injection), and had histologically proven pathologic parathyroid glands were retrospectively included in the study. Early and late images were compared both visually and quantitatively. Results: Sixty-four patients were included, and a total of 71 parathyroid glands were surgically removed. Visually, there were no differences between early and late images of hyperfunctioning parathyroid glands in 44 patients (69%); in 13 patients (20%), visualization on early images was better; in 6 patients (9%), visualization of hyperfunctioning glands was best on late images; and in 1 patient (2%), the lesion was exclusively visualized on late images. For the total cohort, there was a significant decrease in 18 F-FCH uptake in the glands on late versus early time points (P 5 0.001), but there was a significant increase in the ratio of parathyroid uptake to thyroid uptake (P 5 0.037). The group of patients with better visualization on early images showed a decrease over time in both parathyroid uptake and the ratio of parathyroid uptake to thyroid uptake, significant in comparison to those in both the group with better visualization at later time points and the group in which visualization was similar at both time points (P values of 0.000-0.018). There were no significant differences in 18 F-FCH uptake and the ratio of parathyroid uptake to thyroid uptake between the latter 2 groups (P values of 0.200-0.709). Conclusion: In most patients (89%), hyperfunctioning parathyroid glands were adequately visualized on early imaging; however, in a subset of patients (11%), such glands were best visualized at later time points. Therefore, we recommend the acquisition of dual-time-point images in parathyroid imaging with 18 F-FCH PET/CT or the creation of an opportunity to acquire additional late images after review of early images when findings are inconclusive.

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Section: Patient Selectionmentioning

confidence: 99%

Section: Scan Acquisitionmentioning

confidence: 99%

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confidence: 94%

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confidence: 99%

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confidence: 99%

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