Temporal Trends in Human Semen Parameters in New England in the United States, 1989-2000

Chen, Z.; Isaacson, Keith; Toth, Thomas L.; Godfrey‐Bailey, Linda; Schiff, Isaac; Hauser, Russ

doi:10.1080/0145010390219700

Cited by 12 publications

(4 citation statements)

References 20 publications

(13 reference statements)

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“…A decrease in the percentage of sperm with morphologically normal forms was also shown in the previous Paris study (Auger et al, 1995). This trend is coherent with other recent studies (Zheng et al, 1997;Andolz et al, 1999;Almagor et al, 2003;Chen et al, 2003;Feki et al, 2009;Jorgensen et al, 2011). However, a few studies have reported no trend (Zorn et al, 1999;Seo et al, 2000;Lackner et al, 2005;Sripada et al, 2007), and one (Berling and Wolner-Hanssen, 1997) has reported an increase in the percentage of sperm with normal forms.…”

Section: Average Morphologysupporting

confidence: 89%

“…More generally, the results of studies on total motility are contrasted. Many studies do not find any trend (Zorn et al, 1999;Seo et al, 2000;Lackner et al, 2005;Sripada et al, 2007;Fisch, 2008;Feki et al, 2009), some observe a decrease (Auger et al, 1995;Zorn et al, 1999;Almagor et al, 2003;Mukhopadhyay et al, 2010) and a few observe an increase (Andolz et al, 1999;Chen et al, 2003) in motility. These results, combined with the ones observed in the present study, suggest that there is no global trend in total sperm motility.…”

Section: Average Motilitymentioning

confidence: 94%

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Decline in semen concentration and morphology in a sample of 26 609 men close to general population between 1989 and 2005 in France

et al. 2012

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As the men were selected without a priori knowledge regarding their semen quality characteristics, the results are expected to be close to the values in the general French population. The very large sample size and the robustness of the results confer great statistical power and credibility to the results. To our knowledge, it is the first study concluding a severe and general decrease in sperm concentration and morphology at the scale of a whole country over a substantial period. This constitutes a serious public health warning. The link with the environment particularly needs to be determined.

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Section: Average Morphologysupporting

confidence: 89%

Section: Average Motilitymentioning

confidence: 94%

Decline in semen concentration and morphology in a sample of 26 609 men close to general population between 1989 and 2005 in France

et al. 2012

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“…Benshushan et al 42 found a decrease of 1.04% per year over a 15-year period, from 1980 to 1995, in a population of healthy students who donated semen for artificial inseminations. A steady decline of 0.3% per year from 1989 to 2000 in percentage of morphologically normal spermatozoa was also found by Chen et al 43 from Boston in the United States over this 11-year period as seen in semen samples from patients attending their clinic. In their study, the decline in the percentage of morphologically normal spermatozoa was mainly due to increased head defects and to a lesser extend to tail defects.…”

Section: Decreasing Normal Sperm Morphology Valuessupporting

confidence: 67%

Measurement and significance of sperm morphology

Menkveld¹,

Holleboom²,

Rhemrev³

2010

Asian J Androl

144

104

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The measurement or evaluation and clinical significance of human sperm morphology has always been and still is a controversial aspect of the semen analysis for the determination of a male's fertility potential. In this review the background of the development of the evaluation criteria for sperm morphology will be discussed. Aspects of criticism on the strict criteria definition and use of the criteria for sperm morphology evaluation will be discussed as well as possible reasons for the decline in normal sperm morphology values and how we can compromise for this phenomenon resulting in the very low normal reference value as published in the 2010 WHO manual for the Examination and Processing of Human Semen. One of the possible solutions may be to give more attention to a limited number of abnormal sperm morphology categories and the inclusion of sperm morphology patterns. It is concluded in this review that if done correctly and with care and with strict application of existing guidelines as outlined in the 2010 WHO manual, sperm morphology measurement still has a very important role to play in the clinical evaluation of male fertility potential.

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“…Similarly, a retrospective study of 551 semen analysis records reported trends in semen characteristics in New England from 1972 to 1993 (ref. 86 ). After age adjustment, sperm concentration showed a small upward trend of 0.2 × 10 6 /ml per year ( P < 0.01), and the authors also reported a 2.3% per year increase in percentage sperm motility and a 0.3% per year decrease in morphologically normal spermatozoa; however, no P values were reported.…”

Section: Temporal Trends In Human Semen Qualitymentioning

confidence: 99%

Spatiotemporal trends in human semen quality

2022

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Over the past four decades, studies of various designs have reported spatial and temporal trends in human semen quality. Several standardized-methodology studies in homogeneous populations that compare specific cities within a country or a continent provide clear evidence of geographical differences in sperm production, even over short distances within the same country. Human sperm production is widely believed to be declining over time, but evidence from the scientific literature is less clear. Studies based on repeated cross-sectional data from a single centre have shown mixed results. Among the numerous retrospective studies conducted in a single centre, only some included homogeneous groups of men and appropriate methods, and most of them suggest a temporal decrease in human sperm production in the geographical areas considered. Conclusions reporting temporal trends in sperm production that came from existing retrospective multicentre studies based on individual semen data and those using means, medians or estimates of sperm production are questionable, owing to intrinsic limitations in the studies performed. Regardless of study design, studies on the percentage of motile or morphologically normal spermatozoa are still limited by the inherent variability in assessment. Overall, available data do not enable us to conclude that human semen quality is deteriorating worldwide or in the Western world, but that a trend is observed in some specific areas. To understand these trends and contrasts in sperm and semen quality, prospective studies should be encouraged and combined with assessment of the male exposome.

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Temporal Trends in Human Semen Parameters in New England in the United States, 1989-2000

Cited by 12 publications

References 20 publications

Decline in semen concentration and morphology in a sample of 26 609 men close to general population between 1989 and 2005 in France

Decline in semen concentration and morphology in a sample of 26 609 men close to general population between 1989 and 2005 in France

Measurement and significance of sperm morphology

Spatiotemporal trends in human semen quality

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